Simultaneous determination of albi?orin and paeoni?orin in rat urine by solid-phase extraction and high-performance liquid chromatography following oral administration of Si-Wu decoction

2004 ◽  
Vol 18 (10) ◽  
pp. 785-790 ◽  
Author(s):  
Yuxin Sheng ◽  
Lie Li ◽  
Jinlan Zhang ◽  
Dean Guo
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Oral Administration ◽  
Solid Phase Extraction ◽  
Simultaneous Determination ◽  
High Performance ◽  
Solid Phase ◽  
Phase Extraction ◽  
Rat Urine

scholarly journals Simultaneous Determination of Nitroimidazole Residues in Honey Samples by High-Performance Liquid Chromatography with Ultraviolet Detection

2007 ◽  
Vol 90 (3) ◽  
pp. 872-878 ◽  
Author(s):  
Jinhui Zhou ◽  
Jianzhong Shen ◽  
Xiaofeng Xue ◽  
Jing Zhao ◽  
Yi Li ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Solid Phase Extraction ◽  
Simultaneous Determination ◽  
High Performance ◽  
Solid Phase ◽  
Phase Extraction ◽  
Ultraviolet Detection ◽  
Ultraviolet Detector

Abstract A rapid and sensitive high-performance liquid chromatography (LC) method was developed for the simultaneous determination of metronidazole (MNZ), dimetridazole (DMZ), ronidazole (RNZ), tinidazole (TNZ), and 2-hydroxymethyl-1-methyl-5-nitroimidazole (HMMNI) in honey. After extraction with ethyl acetate and evaporation, the residue containing the nitroimidazoles was dissolved in ethyl acetatehexane and subjected to solid-phase extraction cleanup by amine extraction columns. The effluent was evaporated to dryness, and residues were dissolved and determined by LC with an ultraviolet detector set at 315 nm. The limits of detection were 1.02.0 ng/g for MNZ, DMZ, RNZ, TNZ, and HMMNI in honey. Average recoveries ranged from 71.5101.4% in honey fortified at 10, 20, 50, and 100 ng/g. The method was validated for the analysis of real honey samples.

Sign in / Sign up

Export Citation Format

Share Document