A concise review of applications of micellar liquid chromatography to study biologically active compounds

2016 ◽  
Vol 31 (1) ◽  
pp. e3741 ◽  
Author(s):  
Katarzyna E. Stępnik
Keyword(s):  
Liquid Chromatography ◽  
Micellar Liquid Chromatography ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Concise Review

Diverse thiophenes as scaffolds in anti-cancer drug development: A concise review

2020 ◽  
Vol 20 ◽  
Author(s):  
Neha V. Bhilare ◽  
Pratibha B. Auti ◽  
Vinayak S. Marulkar ◽  
Vilas J. Pise
Keyword(s):  
Drug Development ◽  
Anticancer Agents ◽  
Heterocyclic Ring ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Cancer Drug ◽  
Active Compounds ◽  
Natural Origin ◽  
Concise Review ◽  
Anti Cancer

: Thiophenes are one among the abundantly found heterocyclic ring systems in many biologically active compounds. Moreover various substituted thiophenes exert numerous pharmacological actions on account of their isosteric resemblance with compounds of natural origin thus rendering them with diverse actions like antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, antiallergic, hypotensives etc.. In this review we specifically explore the chemotherapeutic potential of variety of structures consisting of thiophene scaffolds as prospective anticancer agents.

scholarly journals Recent theoretical and practical applications of micellar liquid chromatography (MLC) in pharmaceutical and biomedical analysis

2012 ◽  
Vol 10 (3) ◽  
pp. 570-584 ◽  
Author(s):  
Piotr Kawczak ◽  
Tomasz Bączek
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Analysis ◽  
Micellar Liquid Chromatography ◽  
Biologically Active ◽  
Organic Modifiers ◽  
Active Compounds ◽  
Separation Techniques ◽  
Practical Applications ◽  
Wide Range

AbstractMicellar liquid chromatography (MLC) is an analytical technique belonging to the wide range of reversed-phase liquid chromatographic (RP-LC) separation techniques. MLC with the use of surfactant solutions above its critical micellar concentration (CMC) and the addition of organic modifiers is currently an important analytical tool with still growing theoretical considerations and practical applications in pharmaceutical analysis of drugs and other biologically active compounds. The use of MLC as an alternative, relatively much faster in comparison to conventional chromatographic separation techniques has several advantages, especially as being suitable for screening pharmaceutical analysis. The analytical data received from MLC analysis are considered a useful source of information to predict passive drug absorption, drug transport and other pharmacokinetics and physicochemical measures of pharmaceutical substances. In the review several MLC assays for determination of drugs and other active compounds in biological samples were compared and critically discussed. The presented overview provides information on recent applications and achievements connected with the practical use of MLC. The review covers fields of interest related to theory and mechanism of MLC separation, direct applications of MLC in pharmaceutical analysis, including optimization and efficiency of separation with the use of modification of stationary phase and mobile phase compositions as well as the determination of physicochemical characteristics of drugs by MLC.

Nickel(0)-Catalyzed Linear-Selective Hydroarylation of Unactivated Alkenes and Styrenes with Arylboron Acids

2018 ◽  
Author(s):  
Honggui Lv ◽  
Li-Jun Xiao ◽  
Dongbing Zhao ◽  
Qi-Lin Zhou
Keyword(s):  
Butyric Acid ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Highly Efficient ◽  
Organoboronic Acids

Herein, we realized the first linear-selective hydroarylation of unactivated alkenes and styrenes with organoboronic acids by introducing directing groupon alkenes. Our method is highly efficient and scalable, and provides a modular route to assemble structurally diverse alkylarenes, especially for γ-aryl butyric acid derivatives, which have been widely utilized as chemical feedstocks to access multiple marketed drugs, and biologically active compounds.<br>

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