Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study

2015 ◽  
Vol 29 (10) ◽  
pp. 1559-1566 ◽  
Author(s):  
Beata Strach ◽  
Elżbieta Wyska ◽  
Krzysztof Pociecha ◽  
Anna Krupa ◽  
Renata Jachowicz
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Back Extraction

scholarly journals Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Qiang Liu ◽  
Qian Cai ◽  
Chang Liu ◽  
Feng-Wei Bao ◽  
Zhen-Qiu Zhang
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rosmarinic Acid ◽  
Rat Plasma ◽  
Hplc Method ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae ◽  
Hawthorn Extract

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration ofRadix Salviae Miltiorrhizaeextract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

scholarly journals Development of HPLC Method for the Determination of Buspirone in Rat Plasma Using Fluorescence Detection and Its Application to a Pharmacokinetic Study

2016 ◽  
Vol 64 (11) ◽  
pp. 1582-1588 ◽  
Author(s):  
Ki Taek Kim ◽  
Jae-Young Lee ◽  
Ju-Hwan Park ◽  
Min Hwan Kim ◽  
Ji-Su Kim ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method

A simplified and sensitive validated RP-HPLC method for determination of temozolomide in rat plasma and its application to a pharmacokinetic study

2018 ◽  
Vol 41 (10) ◽  
pp. 692-697 ◽  
Author(s):  
Archana Khosa ◽  
Kowthavarapu V. Krishna ◽  
Ranendra N. Saha ◽  
Sunil K. Dubey ◽  
Satish Reddi
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

Validated HPLC method for quantitative determination of talinolol in rat plasma and application to a preclinical pharmacokinetic study

Bioanalysis ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Shriram M Pathak ◽  
Prashant B Musmade ◽  
Krishnamurthy M Bhat ◽  
Nayanabhirama Udupa
Keyword(s):  
Quantitative Determination ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method
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