Determination of a novel anticancer c-Met inhibitor LS-177 in rat plasma and tissues with a validated UPLC-MS/MS method: application to pharmacokinetics and tissue distribution study

2014 ◽  
Vol 29 (7) ◽  
pp. 1103-1111 ◽  
Author(s):  
Ping Ju ◽  
Zhenzhen Liu ◽  
Yu Jiang ◽  
Simin Zhao ◽  
Lunhui Zhang ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Rat Plasma ◽  
Distribution Study ◽  
Met Inhibitor ◽  
Tissue Distribution Study

Quantitative determination of periplocymarin in rat plasma and tissue by LC-MS/MS: application to pharmacokinetic and tissue distribution study

2016 ◽  
Vol 30 (8) ◽  
pp. 1195-1201 ◽  
Author(s):  
Kaijing Yan ◽  
Xiangyang Wang ◽  
Yumeng Jia ◽  
Yang Chu ◽  
Xiufeng Guan ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Tissue Distribution ◽  
Rat Plasma ◽  
Distribution Study ◽  
Tissue Distribution Study

An LC-MS/MS method for determination of novel fungicide pyraoxystrobin in rat plasma and tissues: Toxicokinetics and tissue distribution study

Talanta ◽  
2015 ◽  
Vol 136 ◽  
pp. 183-189 ◽  
Author(s):  
Li H. Lin ◽  
Ming Y. Duan ◽  
Guang Chen ◽  
Xiao H. You ◽  
Chang L. Liu ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Rat Plasma ◽  
Distribution Study ◽  
Tissue Distribution Study

LC Determination of Icariside II in Rat Plasma and Tissues: Application to a Tissue Distribution Study

2011 ◽  
Vol 74 (3-4) ◽  
pp. 251-258
Author(s):  
Chang-Guang Wang ◽  
Jia-Bei Sun ◽  
Jian-Cheng Wang ◽  
Qiang Zhang ◽  
Ying Zheng
Keyword(s):  
Tissue Distribution ◽  
Rat Plasma ◽  
Distribution Study ◽  
Icariside Ii ◽  
Tissue Distribution Study

scholarly journals Determination of (4E,6E,12E)-Tetradecatriene-8,10-diyne-1,3-diyl Diacetate in Rat Plasma and Tissues by HPLC-UV Method and Their Application to a Pharmacokinetic and Tissue Distribution Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Yan Huo ◽  
Yu-Qiang Liu ◽  
Zhong-Xu Bai ◽  
Qian Cai
Keyword(s):  
Tissue Distribution ◽  
Mobile Phase ◽  
High Performance ◽  
Rat Plasma ◽  
Processing Method ◽  
Distribution Study ◽  
Accuracy And Precision ◽  
Digestive Disorders ◽  
Tissue Distribution Study

In ChinaAtractylodis Rhizomais widely used for the treatment of rheumatic diseases and digestive disorders. Stir-frying with wheat bran is the most common processing method. In order to clarify the influence of processing on pharmacological properties ofAtractylodis Rhizoma, an investigation was carried out to compare the pharmacokinetics and tissue distribution of typical constituent after oral administration of rawAtractylodis Rhizomaand processed ones. A simple, rapid, and sensitive high performance liquid chromatography with UV detection was developed and validated for the determination of (4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate in rat plasma. A chromatography was carried out on Diamonsil C18(250 × 4.6 mm; 5 μm) analytical column, using a mobile phase which consisted of acetonitrile and 0.1% phosphoric acid water (60 : 40, v/v) at a flow rate of 1.0 mL·min−1. The wavelength was set at 336 nm. The LLOQ of (4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate was 0.00143 μg·mL−1. Both accuracy and precision were satisfactory. The pharmacokinetic results showed that theTmax⁡was 1 hour in advance and theCmax⁡was increased after processing. Tissue distribution showed that the highest level was in spleen. And the concentrations in the spleen were increased after stir-frying with bran.

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