Development and validation of an LCMS method to determine the pharmacokinetic profiles of caffeic acid phenethyl amide and caffeic acid phenethyl ester in male Sprague-Dawley rats

2013 ◽  
Vol 28 (2) ◽  
pp. 241-246 ◽  
Author(s):  
John Yang ◽  
Phillip D. Bowman ◽  
Sean M. Kerwin ◽  
Salomon Stavchansky
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Sprague Dawley ◽  
Pharmacokinetic Profiles ◽  
Sprague Dawley Rats ◽  
Development And Validation ◽  
Caffeic Acid Phenethyl Amide

Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats

2021 ◽  
pp. 096032712110544
Author(s):  
Halil Sezgin Semis ◽  
Cihan Gur ◽  
Mustafa Ileriturk ◽  
Ozgur Kaynar ◽  
Fatih Mehmet Kandemir
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
High Dose ◽  
Protein Profiles ◽  
Paw Edema ◽  
Sprague Dawley ◽  
Thermal Camera ◽  
Temperature Changes ◽  
X Ray ◽  
Sprague Dawley Rats

In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflammation induced by carragenan (Carr) at macro and micro levels. Therefore, in this study, 1 hour after administering intraperitoneal of indomethacin (Ind) or CAPE (10 and 30 mg/kg body weight) to Sprague Dawley rats, Carr was injected intraplantarly into their right paws. The paw volumes of the rats were measured with a plethysmometer until the 4th hour. Also, X-ray and thermal camera images were taken to determine edema and temperature changes. At the end of the study, after the paw tissues and serums were taken, oxidative stress and inflammation status were determined using biochemical, molecular, and western blot techniques. In addition, lipid and protein profiles in paw tissue were determined using HPTLC and electrophoresis methods. The results depicted that a high dose of CAPE against Carr-induced inflammation may be almost as effective as Ind used as reference.

Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-β-cyclodextrin

2018 ◽  
Vol 254 ◽  
pp. 260-265 ◽  
Author(s):  
E. Manuela P.J. Garrido ◽  
Ana S. Cerqueira ◽  
Daniel Chavarria ◽  
Tiago Silva ◽  
Fernanda Borges ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Caffeic Acid Phenethyl Amide

The Dietary Hydroxycinnamate Caffeic Acid and Its Conjugate Chlorogenic Acid Increase Vitamin E and Cholesterol Concentrations in Sprague−Dawley Rats

2003 ◽  
Vol 51 (9) ◽  
pp. 2526-2531 ◽  
Author(s):  
Jan Frank ◽  
Afaf Kamal-Eldin ◽  
Alexander Razdan ◽  
Torbjörn Lundh ◽  
Bengt Vessby
Keyword(s):  
Vitamin E ◽  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Acetyl-L-Carnitine protects against LPS induced depression via PPAR-γ induced inhibition of NF-κB/NLRP3 pathway

2021 ◽  
Author(s):  
Amna Samin ◽  
Lina Tariq Al Kury ◽  
MUHAMMAD IMRAN KHAN ◽  
Shabir Hussain ◽  
Abdullah Alattar ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Nlrp3 Inflammasome ◽  
Caffeic Acid Phenethyl Ester ◽  
Peroxisome Proliferator ◽  
Depression And Anxiety ◽  
Sprague Dawley ◽  
Neuroprotective Effects ◽  
Pyrin Domain ◽  
Ppar Γ ◽  
Peroxisome Proliferator Activated Receptors

IntroductionMajor depressive disorder (MDD) is a debilitating human health status characterized by mood swings and high suicidal attempts. Several studies have reported the role of neuroinflammation in MMD, yet the efficacy of natural drug substances on neuroinflammation-associated depression needs to be further investigated. The present study demonstrated the neuroprotective effects of Acetyl-L- carnitine (ALC) alone or in combination with caffeic acid phenethyl ester (CAPE) on lipopolysaccharide (LPS) induced neuro-inflammation, depression, and anxiety-like behavior.Material and methodsMale Sprague Dawley (SD) rats were used to explore the relative effects of ALC and the mechanistic interplay of the peroxisome proliferator-activated receptors (PPARγ) in depression. Lipopolysaccharide (LPS) was administered to induce depression and anxiety-like symptoms such as a decreased grooming tendency, diminished locomotive activity, and increased immobility period.ResultsWe found marked neuronal alterations in the cortex and hippocampus of LPS intoxicated animals associated with higher inflammatory cytokines expression cyclooxygenase (COX2), tumor necrotic factor-alpha (TNF-α). These detrimental effects exacerbate oxidative stress as documented by a compromised antioxidant system due to high lipid peroxidase (LPO). ALC significantly reverted these changes by positively modulating the PPARγ dependent downstream antioxidant and anti-inflammatory pathways such as NOD and pyrin domain-containing protein 3 (NLRP3) linked nuclear factor kappa B (NF-κB) phosphorylation. Moreover, co-administering NF-κB inhibitor caffeic acid phenethyl ester (CAPE) with ALC also increased PPARγ expression significantly and decreased NF-ᴋB and NLRP3 inflammasome.ConclusionsThese findings indicate that ALC could be a possible depression supplement. The effects are partly mediated by inhibiting neuroinflammation and NLRP3 inflammasome coupled to PPARγ upregulations.

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