Recent research trends in fluorescent reporters‐based lateral flow immunoassay for protein biomarkers specific to acute myocardial infarction

2021 ◽  
Author(s):  
Mulya Supianto ◽  
Hye Jin Lee
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Research Trends ◽  
Lateral Flow ◽  
Lateral Flow Immunoassay ◽  
Protein Biomarkers ◽  
Fluorescent Reporters

5G-Enabled intelligent construction of a chest pain center with up-conversion lateral flow immunoassay

The Analyst ◽  
2021 ◽  
Author(s):  
Lei Huang ◽  
Shulin Tian ◽  
Wenhao Zhao ◽  
Ke Liu ◽  
Xing Ma ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Chest Pain ◽  
High Mortality ◽  
Health Problem ◽  
Rapid Onset ◽  
Lateral Flow ◽  
Lateral Flow Immunoassay ◽  
Pain Center

Acute myocardial infarction (AMI) has become a worldwide health problem because of its rapid onset and high mortality.

scholarly journals Discovery of potential plasma protein biomarkers for acute myocardial infarction via proteomics

2019 ◽  
Vol 11 (9) ◽  
pp. 3962-3972 ◽  
Author(s):  
Shasha Xu ◽  
Jianjun Jiang ◽  
Yang Zhang ◽  
Tingting Chen ◽  
Min Zhu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Plasma Protein ◽  
Protein Biomarkers

scholarly journals Proteomic Profiles of Young Adults with Acute Myocardial Infarction

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Norbaiyah Mohamed Bakrim ◽  
Azarisman Shah Mohd Shah ◽  
Aida Nur Sharini Mohd. Shah ◽  
Norlelawati A. Talib ◽  
Jamalludin A. Rahman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Adults ◽  
Young Patients ◽  
Molecular Study ◽  
Specific Protein ◽  
Protein Biomarkers ◽  
Control Subjects ◽  
New Biomarkers ◽  
Apo Ai

Introduction: The incidence of acute myocardial infarction (AMI) in young adults is increasing. However, a molecular study focusing on the pathophysiological changes in young AMI remains limited. This study aims to examine the proteomic profile of young adults with AMI compared to control subjects. We also hope to identify disease-specific protein biomarkers that contribute to the development of AMI in the young. Materials and Methods: Pooled plasma protein from 10 AMI patients aged 18 to 45 years and 10 age, gender and race-matched volunteers were separated using two dimensional electrophoresis (2-DE). The protein spots were analysed using the PD Quest analysis software. The protein spots that were found to have been expressed differently between the two groups were identified by Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometry. Results: There were three differently expressed protein spots, namely Apolipoprotein AI (Apo AI), Apolipoprotein AIV (Apo AIV) and Haptoglobin. The expressions of these proteins were found to be increased in young patients with AMI compared to control subjects (p< 0.05). Conclusion:The up-regulation of Apo AI, Apo AIV and Haptoglobin in AMI patients could be in response to the inflammatory process associated with the recent cardiac event. The current study seems to reveal a significant function of these proteins during the acute phase response. Thus, Apo AI, Apo AIV and Haptoglobin are potential new biomarkers for young AMI.

An enhanced centrifugation-assisted lateral flow immunoassay for the point-of-care detection of protein biomarkers

Lab on a Chip ◽  
2020 ◽  
Vol 20 (15) ◽  
pp. 2626-2634 ◽  
Author(s):  
Minjie Shen ◽  
Nan Li ◽  
Ying Lu ◽  
Jing Cheng ◽  
Youchun Xu
Keyword(s):  
Point Of Care ◽  
Lateral Flow ◽  
Lateral Flow Immunoassay ◽  
Protein Biomarkers ◽  
Protein Biomarker ◽  
Blood Samples ◽  
Point Of Care Detection

An enhanced centrifugation-assisted lateral flow immunoassay was proposed for automated protein biomarker detections using blood samples within 15 minutes.

scholarly journals Proteomic Profiles of Young Adults with Acute Myocardial Infarction

2020 ◽  
Vol 18 (3) ◽  
Author(s):  
Mohamed Bakrim N ◽  
Mohd Shah AS ◽  
Mohd. Shah ANS ◽  
A. Talib N ◽  
A.Rahman J ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Adults ◽  
Young Patients ◽  
Specific Protein ◽  
Proteomic Profiling ◽  
Protein Biomarkers ◽  
Multifactorial Diseases ◽  
Control Subjects ◽  
Apo Ai

Introduction: Proteomic profiling is essential in understanding the pathophysiological process of multifactorial diseases such as acute myocardial infarction (AMI). Despite the increasing incidence of AMI in young adults, proteomic-based study focusing on young AMI remains limited. This study aimed to examine the plasma proteomic profiles of young adults with AMI compared to control subjects. We also hope to identify disease-specific protein biomarkers that contribute to the development of AMI in the young. Methods: Pooled plasma protein from 10 AMI patients aged 18 to 45 years and 10 age, gender and race - matched volunteers were separated using two-dimensional electrophoresis (2-DE). The spots proteins were analysed using the PD Quest analysis software. The spots proteins that were found to have been expressed differently between the two groups were identified by Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometry. Results: There were three differently expressed proteins namely Apolipoprotein AI (Apo AI), Apolipoprotein AIV (Apo AIV) and Haptoglobin (p < 0.05). The expressions of these proteins were found to be increased in young patients with AMI compared to control subjects. Conclusion: The up regulation of Apo AI, Apo AIV and Haptoglobin in AMI patients indicate their important roles in the development of atherosclerotic disease. Thus, Apo AI, Apo AIV and Haptoglobin are potential disease biomarkers for young AMI.

An electron microscopic study of the intra-myocardial lesions in cases of acute myocardial infarction

1978 ◽  
Vol 36 (2) ◽  
pp. 484-485
Author(s):  
Masahiro Ono ◽  
Kaoru Aihara ◽  
Gompachi Yajima
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Vessels ◽  
Vascular Wall ◽  
Vascular Changes ◽  
Electron Microscopic ◽  
Main Trunk ◽  
Mechanical Destruction ◽  
Transmission Electron ◽  
Myocardial Lesions

The pathogenesis of the arteriosclerosis in the acute myocardial infarction is the matter of the extensive survey with the transmission electron microscopy in experimental and clinical materials. In the previous communication,the authors have clarified that the two types of the coronary vascular changes could exist. The first category is the case in which we had failed to observe no occlusive changes of the coronary vessels which eventually form the myocardial infarction. The next category is the case in which occlusive -thrombotic changes are observed in which the myocardial infarction will be taken placed as the final event. The authors incline to designate the former category as the non-occlusive-non thrombotic lesions. The most important findings in both cases are the “mechanical destruction of the vascular wall and imbibition of the serous component” which are most frequently observed at the proximal portion of the coronary main trunk.

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