Extremely Low‐Frequency Electromagnetic Field Altered PPARγ and CCL2 Levels and Suppressed CD44 + / CD24 − Breast Cancer Cells Characteristics

2020 ◽  
Vol 41 (8) ◽  
pp. 812-823
Author(s):  
In‐Rok Oh ◽  
Bernardo Raymundo ◽  
Sung A Jung ◽  
Hyun Jung Kim ◽  
Jung‐Keug Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Electromagnetic Field ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Low Frequency ◽  
Extremely Low Frequency

A proteomics approach in evaluating extremely low frequency electromagnetic field-induced apoptosis in breast cancer cells

2018 ◽  
Vol 92 ◽  
pp. S134
Author(s):  
Reyhane Ghadirian ◽  
Alireza Madjid Ansari ◽  
Leila Farahmand ◽  
Hasan Sanati ◽  
Zahra S. Mesbah Moosavi
Keyword(s):  
Breast Cancer ◽  
Electromagnetic Field ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Low Frequency ◽  
Extremely Low Frequency ◽  
Proteomics Approach ◽  
Induced Apoptosis

scholarly journals EFFECTS OF EXTREMELY LOW-FREQUENCY MAGNETIC FIELD ON HEALTHY FIBROBLASTS AND BREAST CANCER CELLS

2020 ◽  
Vol 83 (4) ◽  
Author(s):  
Handan Kayhan ◽  
Babek Erdebilli ◽  
Sevim Gönen ◽  
Meriç Arda Eşmekaya ◽  
Ersen Ertekin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Field ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Low Frequency ◽  
Extremely Low Frequency ◽  
Frequency Magnetic Field

Effect of extremely low frequency magnetic fields on the metastatic characteristics of breast cancer cells

2018 ◽  
Vol 92 ◽  
pp. S103
Author(s):  
R. Rashidnezhad ◽  
A. Madjid Ansari ◽  
M. Shokrollahy ◽  
H. Sanati ◽  
Z.S. Mesbah Moosavi
Keyword(s):  
Breast Cancer ◽  
Magnetic Fields ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Low Frequency ◽  
Extremely Low Frequency

scholarly journals Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells

2020 ◽  
Vol 21 (8) ◽  
pp. 2952
Author(s):  
Aoshu Xu ◽  
Qian Wang ◽  
Tingting Lin
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Magnetic Fields ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Glycogen Synthase ◽  
Low Frequency ◽  
Cell Cycle Distribution ◽  
Cell Proliferation Inhibition

Breast cancer is a common malignancy threatening women’s health around the world. Despite improved treatments for different subtypes of breast tumors that have been put forward, there still exists a poor therapeutic response and prognosis. Magnetic fields, as a non-invasive therapy, have shown anti-tumor effects in vitro and in vivo; however, the detailed mechanisms involved are still not clear. In this study, we found that in exposure to low-frequency magnetic fields (LF-MFs) with an intensity of 1 mT and frequencies of 50, 125, 200, and 275 Hz, separately, the proliferation of breast cancer cells was inhibited and LF-MF with 200 Hz reached the optimum inhibition effect, on exposure time-dependently. Notably, we found that exposure to LF-MF led to MCF-7 and ZR-75-1 cell apoptosis and cell cycle arrest. Moreover, we also discovered that LF-MF effectively increased the level of reactive oxygen species (ROS), suppressed the PI3K/AKT signaling pathway, and activated glycogen synthase kinase-3β (GSK-3β). We demonstrated that the GSK3β activity contributed to LF-MF-induced cell proliferation inhibition and apoptosis, while the underlying mechanism was associated with the inhibition of PI3K/AKT through increasing the intracellular ROS accumulation. These results indicate that LF-MF with a specific frequency may be an attractive therapy to treat breast cancers.

Sign in / Sign up

Export Citation Format

Share Document