Structure Characterization of Degradation Products of Drug Candidate HM30571 by UPLC‐QTOF‐MS and In Silico Toxicity Prediction

2019 ◽  
Vol 41 (1) ◽  
pp. 92-95
Author(s):  
Hyojeong Bang ◽  
Wankyunn Whang ◽  
Keukchan Bang ◽  
Eunyoung Lee ◽  
Eunyoung Kim ◽  
...  
Keyword(s):  
In Silico ◽  
Degradation Products ◽  
Structure Characterization ◽  
Drug Candidate ◽  
Toxicity Prediction ◽  
In Silico Toxicity

Identification of Degradation Products and Process Impurities from Terbutaline Sulfate by UHPLC-Q-TOF-MS/MS and In Silico Toxicity Prediction

2017 ◽  
Vol 80 (5) ◽  
pp. 793-804 ◽  
Author(s):  
Na Zhou ◽  
Qi Qian ◽  
Pengcheng Qi ◽  
Jie Zhao ◽  
Chunying Wang ◽  
...  
Keyword(s):  
In Silico ◽  
Degradation Products ◽  
Toxicity Prediction ◽  
Terbutaline Sulfate ◽  
In Silico Toxicity ◽  
Tof Ms

LC/QTOF/MS/MS characterization, molecular docking and in silico toxicity prediction studies on degradation products of anagliptin

2018 ◽  
Vol 159 ◽  
pp. 92-99 ◽  
Author(s):  
Shandilya Mahamuni Baira ◽  
Dilep Kumar Sigalapalli ◽  
Nagendra Babu Bathini ◽  
Srinivas R. ◽  
M.V.N Kumar Talluri
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Degradation Products ◽  
Toxicity Prediction ◽  
In Silico Toxicity

Characterization of stress degradation products of mirabegron using UPLC-QTOF-MS/MS and in silico toxicity predictions of its degradation products

RSC Advances ◽  
2015 ◽  
Vol 5 (39) ◽  
pp. 31024-31038 ◽  
Author(s):  
Pradipbhai D. Kalariya ◽  
Mahesh Sharma ◽  
Prabha Garg ◽  
Jagadeshwar Reddy Thota ◽  
Srinivas Ragampeta ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
In Silico ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Degradation Products ◽  
Stress Degradation ◽  
In Silico Toxicity ◽  
Adrenergic Receptor Agonist ◽  
Bladder Disorder

Mirabegron is a novel beta-3 adrenergic receptor agonist in the treatment of overactive bladder disorder.

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