Design and Synthesis of Novel 2,4-Diamino-5-pyrazol-4-yl Pyrimidine Derivatives as Selective Tyro3 Kinase Inhibitors

2018 ◽  
Vol 39 (9) ◽  
pp. 1101-1104 ◽  
Author(s):  
Dukwoon Kim ◽  
Kyung Won Lee ◽  
Hyunseok Jung ◽  
Miok Kim ◽  
Joo-Youn Lee ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Pyrimidine Derivatives ◽  
Design And Synthesis

Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors

2011 ◽  
Vol 21 (8) ◽  
pp. 2264-2269 ◽  
Author(s):  
Hans-Peter Buchstaller ◽  
Lars Burgdorf ◽  
Dirk Finsinger ◽  
Frank Stieber ◽  
Christian Sirrenberg ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Design And Synthesis ◽  
Raf Kinase

Rational design and synthesis of novel Syk-kinase inhibitors

2012 ◽  
Vol 22 (2) ◽  
pp. 73-74 ◽  
Author(s):  
Alexey A. Zeifman ◽  
Ilya Yu. Titov ◽  
Igor V. Svitanko ◽  
Tatiana V. Rakitina ◽  
Aleksey V. Lipkin ◽  
...  
Keyword(s):  
Rational Design ◽  
Kinase Inhibitors ◽  
Design And Synthesis ◽  
Syk Kinase

Design and Synthesis of New [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Potential Antiproliferative Agents

2015 ◽  
Vol 36 (7) ◽  
pp. 1863-1873 ◽  
Author(s):  
Ahmed Elkamhawy ◽  
Mohammad M. Al-Sanea ◽  
Chiman Song ◽  
Taebo Sim ◽  
Eun Joo Roh
Keyword(s):  
Pyrimidine Derivatives ◽  
Antiproliferative Agents ◽  
Design And Synthesis

scholarly journals Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors

2014 ◽  
Vol 5 (12) ◽  
pp. 1340-1340
Author(s):  
Sharadha Subramanian ◽  
Abran Costales ◽  
Teresa E. Williams ◽  
Barry Levine ◽  
Christopher M. McBride ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Design And Synthesis ◽  
Raf Kinase ◽  
Orally Bioavailable

N-Phenyl-N-purin-6-yl ureas: The design and synthesis of p38α MAP kinase inhibitors

2003 ◽  
Vol 13 (6) ◽  
pp. 1191-1194 ◽  
Author(s):  
Zehong Wan ◽  
Jeffrey C. Boehm ◽  
Michael J. Bower ◽  
Shouki Kassis ◽  
John C. Lee ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Design And Synthesis ◽  
P38α Map Kinase

ChemInform Abstract: Single Step Synthesis of New Fused Pyrimidine Derivatives and Their Evaluation as Potent Aurora-A Kinase Inhibitors.

ChemInform ◽  
2011 ◽  
Vol 43 (4) ◽  
pp. no-no
Author(s):  
Mohamed R. Shaaban ◽  
Tamer S. Saleh ◽  
Abdelrahman S. Mayhoub ◽  
Ahmad M. Farag
Keyword(s):  
Kinase Inhibitors ◽  
Single Step ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Pyrimidine Derivatives

Synthesis and anticancer activity of some pyrido[2,3-d]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors

2019 ◽  
Vol 11 (18) ◽  
pp. 2395-2414 ◽  
Author(s):  
Safinaz E-S Abbas ◽  
Riham F George ◽  
Eman M Samir ◽  
Mostafa MA Aref ◽  
Hatem A Abdel-Aziz
Keyword(s):  
Cell Cycle ◽  
Anticancer Agents ◽  
Kinase Inhibitors ◽  
Cytotoxic Agents ◽  
Cyclin Dependent Kinase ◽  
Apoptosis Induction ◽  
Pyrimidine Derivatives ◽  
Induced Apoptosis ◽  
Emergence Of Resistance ◽  
Mcf 7

Aim: Due to emergence of resistance to available anticancer agents, there is a need to search for new cytotoxic agents. Methods: Pyrido[2,3- d]pyrimidines (4–6) and their tricyclic derivatives (7–13) were prepared and screened for their cytotoxicity against breast MCF-7, prostate PC-3 and lung A-549 cancer cell lines as well as normal fibroblasts WI-38. Results: The most active compounds were 6b, 6e and 8d compared with doxorubicin. Moreover, compounds 6b and 8d induced apoptosis in PC-3 and MCF-7, respectively via activation of CASP3 (in PC-3 only), Bax, p53 and down regulation of Bcl2 in addition to CDK4/6 inhibition. Conclusion: Pyrido[2,3- d]pyrimidine represents an important core for discovery of new potent cytotoxic agents acting on the cell cycle via apoptosis induction through either intrinsic or extrinsic pathways.

New pyrazolo-triazolo-pyrimidine derivatives as antibacterial agents: Design and synthesis, molecular docking and DFT studies

2020 ◽  
Vol 1199 ◽  
pp. 127007 ◽  
Author(s):  
Mabrouk Horchani ◽  
Amel Hajlaoui ◽  
Abdel Halim Harrath ◽  
Lamjed Mansour ◽  
Hichem Ben Jannet ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antibacterial Agents ◽  
Dft Studies ◽  
Pyrimidine Derivatives ◽  
Design And Synthesis
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