Design and Synthesis of Novel Pyrazolo[3,4-d]pyrimidin-1-yl piperidine Derivatives as Bruton's Tyrosine Kinase Inhibitors

2017 ◽  
Vol 38 (2) ◽  
pp. 278-281 ◽  
Author(s):  
Hyebin Park ◽  
Chi Hoon Park ◽  
Seung-Tae Kang ◽  
Jeong Hee Jeon ◽  
Raghavendra Archary ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Design And Synthesis

scholarly journals Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (4) ◽  
pp. 697-704 ◽  
Author(s):  
Haiyang Chen ◽  
Peiran Song ◽  
Yanyan Diao ◽  
Yongjia Hao ◽  
Dou Dou ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Enzymatic Activity ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase

Compound6potently inhibited the enzymatic activity of BTK with an IC50value of 1.9 nM.

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