Novel Solid-phase and Solution-phase Synthetic Methods for Trisubstituted Thieno[3,2-d]pyrimidine Derivatives

2016 ◽  
Vol 37 (9) ◽  
pp. 1406-1414
Author(s):  
Moon-Kook Jeon ◽  
Jung-Gyu Kim ◽  
Duck-Hyung Lee
Keyword(s):  
Solid Phase ◽  
Solution Phase ◽  
Synthetic Methods ◽  
Pyrimidine Derivatives

scholarly journals Fluorous methods for synthesis and separation of organic molecules

2000 ◽  
Vol 72 (9) ◽  
pp. 1649-1653 ◽  
Author(s):  
Dennis P. Curran
Keyword(s):  
Organic Molecules ◽  
Solid Phase ◽  
Liquid Extraction ◽  
Parallel Synthesis ◽  
Solution Phase ◽  
Phase Extraction ◽  
Organic Reaction ◽  
Reverse Phase ◽  
Liquid Liquid Extraction ◽  
Fluorous Tag

Fluorous molecules partition out of an organic phase and into a fluorous (highly fluorinated) phase in a liquid-liquid extraction. New fluorous techniques allow simple yet substantive separations of organic reaction mixtures based on the presence or absence of a fluorous tag. Fluorous-tagged molecules can also be separated from nontagged molecules by solid phase extraction over fluorous reverse-phase silica gel. This technique is ideal for solution-phase parallel synthesis because it allows simple yet substantive separations of organic reaction mixtures.

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