RNA Motifs Required for Maintaining Metabolic Stability of M1 RNA

2016 ◽  
Vol 37 (8) ◽  
pp. 1381-1384 ◽  
Author(s):  
Yool Kim ◽  
Shinae Suk ◽  
Ji Young Lee ◽  
Jee Soo Choi ◽  
Heegwon Shin ◽  
...  
Keyword(s):  
Metabolic Stability ◽  
Rna Motifs ◽  
M1 Rna

Absorption, Metabolic Stability and Protein Binding Properties of Sutherlandioside B from Sutherlandia frutescens

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
VLM Madgula ◽  
B Avula ◽  
X Fu ◽  
XC Li ◽  
TJ Smillie ◽  
...  
Keyword(s):  
Protein Binding ◽  
Metabolic Stability ◽  
Binding Properties ◽  
Sutherlandia Frutescens

Structures of Artificially Designed RNA Nanoarchitectures at Near-Atomic Resolution

2020 ◽  
Author(s):  
Di Liu ◽  
Yaming Shao ◽  
Joseph A. Piccirilli ◽  
Yossi Weizmann
Keyword(s):  
Nucleic Acid ◽  
High Resolution ◽  
Single Strand ◽  
Atomic Resolution ◽  
Rna Motifs ◽  
X Ray ◽  
Structural Details ◽  
Rna Motif

<p>Though advances in nanotechnology have enabled the construction of synthetic nucleic acid based nanoarchitectures with ever-increasing complexity for various applications, high-resolution structures are lacking due to the difficulty of obtaining good diffracting crystals. Here we report the design of RNA nanostructures based on homooligomerizable tiles from an RNA single-strand for X-ray determination. Three structures are solved to near-atomic resolution: a 2D parallelogram, an unexpectedly formed 3D nanobracelet, and a 3D nanocage. Structural details of their constituent motifs—such as kissing loops, branched kissing-loops and T-junctions—that resemble natural RNA motifs and resisted X-ray determination are revealed. This work unveils the largely unexplored potential of crystallography in gaining high-resolution feedback for nanostructure design and suggests a novel route to investigate RNA motif structures by configuring them into nanoarchitectures.</p>

A metabolic stability determination of Tetrahydrothiazolopyridine derivative a selective 11β-hydroxy steroid dehydrogenase type 1 (11β-hsd1) inhibitor

2017 ◽  
Vol 8 (3) ◽  
Author(s):  
MURUGESH KANDASAMY ◽  
MUHAMMED SALIHIN ◽  
MALLIKARJUNA RAO PICHIKA ◽  
SLAVKO KOMARNYTSKY ◽  
THIRUMURUGAN RATHINASABAPATHY
Keyword(s):  
Metabolic Stability ◽  
Hydroxy Steroid ◽  
Steroid Dehydrogenase

scholarly journals Exploring the Metabolic Stability of Engineered Hairy Roots after 16 Years Maintenance

2016 ◽  
Vol 7 ◽  
Author(s):  
Suvi T. Häkkinen ◽  
Elisabeth Moyano ◽  
Rosa M. Cusidó ◽  
Kirsi-Marja Oksman-Caldentey
Keyword(s):  
Hairy Roots ◽  
Metabolic Stability

Discovery of 4-Substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro [4.5]decan-1-one as a Novel Class of Highly Selective GlyT1 Inhibitors with Improved Metabolic Stability.

ChemInform ◽  
2006 ◽  
Vol 37 (51) ◽  
Author(s):  
Daniela Alberati ◽  
Dominik Hainzl ◽  
Synese Jolidon ◽  
Eva A. Krafft ◽  
Anke Kurt ◽  
...  
Keyword(s):  
Metabolic Stability

scholarly journals Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L

MedChemComm ◽  
2013 ◽  
Vol 4 (5) ◽  
pp. 822 ◽  
Author(s):  
Lisheng Deng ◽  
Li Zhang ◽  
Yuan Yao ◽  
Cong Wang ◽  
Michele S. Redell ◽  
...  
Keyword(s):  
Histone Methyltransferase ◽  
Metabolic Stability ◽  
Synthesis Activity

scholarly journals Relative Metabolic Stability, but Disrupted Circadian Cortisol Secretion during the Fasting Month of Ramadan

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60917 ◽  
Author(s):  
Suhad Bahijri ◽  
Anwar Borai ◽  
Ghada Ajabnoor ◽  
Altaf Abdul Khaliq ◽  
Ibrahim AlQassas ◽  
...  
Keyword(s):  
Metabolic Stability ◽  
Cortisol Secretion
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