scholarly journals Anastomotic leakage after elective colorectal surgery: a prospective multicentre observational study on use of the Dutch leakage score, serum procalcitonin and serum C‐reactive protein for diagnosis

BJS Open ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 499-507 ◽  
Author(s):  
◽  
M. Catarci ◽  
G. Ruffo ◽  
F. Borghi ◽  
A. Patriti ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Observational Study ◽  
Anastomotic Leakage ◽  
C Reactive Protein ◽  
Elective Colorectal Surgery ◽  
Reactive Protein

scholarly journals Preoperative C-reactive protein and other inflammatory markers as predictors of postoperative complications in patients with colorectal neoplasia

2021 ◽  
Author(s):  
Sufana Alsaif ◽  
Ailín C Rogers ◽  
Priscilla Pua ◽  
Paul T Casey ◽  
Geoff G Aherne ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Colorectal Surgery ◽  
Inflammatory Markers ◽  
Postoperative Morbidity ◽  
Colorectal Neoplasia ◽  
Full Blood Count ◽  
C Reactive Protein ◽  
Elective Colorectal Surgery ◽  
Reactive Protein ◽  
Grade 3

Abstract Background: Inflammatory markers are measured following colorectal surgery to detect postoperative complications. However, the association of these markers preoperatively with subsequent postoperative course has not yet been usefully studied. Aim: The aim of this study is to assess the ability of preoperative C-reactive protein (CRP) and other inflammatory marker measurements in the prediction of postoperative morbidity after elective colorectal surgery. Methods: This retrospective study catalogues 218 patients undergoing elective, potentially-curative surgery for colorectal neoplasia. Preoperative laboratory results of the full blood count (FBC), C-reactive protein (CRP) and carcinoembryonic antigen (CEA) were recorded. Multivariable analysis was performed to examine preoperative variables against 30-day postoperative complications by type and grade (Clavien-Dindo (CD)), adjusting for age, sex, BMI, smoking status, medical history, open versus laparoscopic operation, and tumor characteristics. Results: Elevated preoperative CRP (≥ 5 mg/L) was significantly predictive of all-cause mortality, with an OR of 17.0 (p < 0.001) and was the strongest factor to predict a CD morbidity grade ≥ 3 (OR 41.9, p < 0.001). Other factors predictive of CD morbidity grade ≥ 3 included smoking, elevated preoperative platelet count and elevated preoperative neutrophil-lymphocyte ratio (OR 15.6, 8.6 and 6.3 respectively, all p < 0.05). CRP values above 5.5 mg/L were indicative of all-cause morbidity (AUC=0.871), and values above 17.5 mg/L predicted severe complications (AUC=0.934). Conclusions: Elevated preoperative CRP predicts increased postoperative morbidity in this patient cohort. The results herein aid risk and resource stratification and encourage preoperative assessment of inflammatory propensity besides simple sepsis exclusion.

scholarly journals Usefulness of Presepsin for the Early Detection of Infectious Complications after Elective Colorectal Surgery, Compared with C-Reactive Protein and Procalcitonin

2021 ◽  
Author(s):  
Erika Amanai ◽  
Kishiko Nakai ◽  
Junichi Saito ◽  
Eiji Hashiba ◽  
Takuya Miura ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Early Detection ◽  
Postoperative Mortality ◽  
Clinical Problem ◽  
Diagnostic Value ◽  
Infectious Complications ◽  
Infected Group ◽  
C Reactive Protein ◽  
Elective Colorectal Surgery ◽  
Reactive Protein

Abstract Background: Infectious complications remain a major clinical problem in colorectal surgery, contributing to prolonged hospital stays, additional costs and significant postoperative mortality. Presepsin has been reported to be a useful marker to diagnose sepsis, similar or superior to procalcitonin (PCT) and C-reactive protein (CRP), and plasma presepsin concentrations are associated with the severity of sepsis and its outcome. The aim of this study was to assess the diagnostic value of presepsin in the early detection of infectious complications after elective colorectal surgery, compared with CRP and PCT.Methods: This study was a prospective observational study. Patients of age >18 who underwent elective colon resections were enrolled and patients with end-stage kidney disease were excluded. Blood samples were collected just before surgery and on postoperative day (POD) 1, 2, 3, 4, and 6. Infectious complications were diagnosed by surgeons. Results: A total of 114 patients were examined, and 27 patients (23.7%) developed infectious complications: 11 anastomotic leaks, 13 intra-abdominal infections, and 3 wound infections. CRP and PCT markedly increased from POD1 to POD3 and then gradually decreased toward POD6 in both groups, but the trends of the decrease in the infected group were blunt, compared with those in the non-infected group. On the other hand, presepsin did not show major changes just after surgery, but it increased on POD4 and POD6, when the complications occurred. ROC analysis to predict infectious complications revealed that the best accuracy was obtained on POD 6 for all biomarkers. CRP showed excellent predictability and presepsin showed good predictability. However, the cut-off values of all biomarkers were relatively lower than expected. Conclusions: The trends of change in presepsin following colorectal surgeries were distinct from those of CRP and PCT. Monitoring the presepsin trends after colorectal surgeries could be helpful to detect postoperative infectious complications.Trial registration: UMIN000025313. Registered on 17 December 2016.

P0072 C-reactive protein 24h after colorectal surgery as an early predictor for anastomotic leakage: A preliminary study

2015 ◽  
Vol 51 ◽  
pp. e15
Author(s):  
E. Morandi ◽  
M. Monteleone ◽  
D.A. Merlini ◽  
G. Vignati ◽  
T. D’Aponte ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Preliminary Study ◽  
Early Predictor

Biomarkers and anastomotic leakage in colorectal surgery: C-reactive protein trajectory is the gold standard

2017 ◽  
Vol 88 (5) ◽  
pp. 440-444 ◽  
Author(s):  
Stephen R. Smith ◽  
Peter Pockney ◽  
Ryan Holmes ◽  
Fiona Doig ◽  
John Attia ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
Gold Standard ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Comparison of C-reactive protein and procalcitonin as predictors of postoperative infectious complications after elective colorectal surgery

2012 ◽  
Vol 53 (6) ◽  
pp. 612-619 ◽  
Author(s):  
Dagmar Oberhofer ◽  
Josip Juras ◽  
Ana Marija Pavičić ◽  
Iva Rančić Žurić ◽  
Vlatko Rumenjak
Keyword(s):  
Colorectal Surgery ◽  
Infectious Complications ◽  
C Reactive Protein ◽  
Elective Colorectal Surgery ◽  
Reactive Protein

scholarly journals Preoperative C-reactive protein and other inflammatory markers as predictors of postoperative complications in patients with colorectal neoplasia

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Sufana H. Alsaif ◽  
Ailín C. Rogers ◽  
Priscilla Pua ◽  
Paul T. Casey ◽  
Geoff G. Aherne ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Colorectal Surgery ◽  
Inflammatory Markers ◽  
Postoperative Morbidity ◽  
Colorectal Neoplasia ◽  
Full Blood Count ◽  
C Reactive Protein ◽  
Elective Colorectal Surgery ◽  
Reactive Protein ◽  
Grade 3

Abstract Background Inflammatory markers are measured following colorectal surgery to detect postoperative complications. However, the association of these markers preoperatively with subsequent postoperative course has not yet been usefully studied. Aim The aim of this study is to assess the ability of preoperative C-reactive protein (CRP) and other inflammatory marker measurements in the prediction of postoperative morbidity after elective colorectal surgery. Methods This is a retrospective study which catalogs 218 patients undergoing elective, potentially curative surgery for colorectal neoplasia. Preoperative laboratory results of the full blood count (FBC), C-reactive protein (CRP) and carcinoembryonic antigen (CEA) were recorded. Multivariable analysis was performed to examine preoperative variables against 30-day postoperative complications by type and grade (Clavien-Dindo (CD)), adjusting for age, sex, BMI, smoking status, medical history, open versus laparoscopic operation, and tumor characteristics. Results Elevated preoperative CRP (≥ 5 mg/L) was significantly predictive of all-cause mortality, with an OR of 17.0 (p < 0.001) and was the strongest factor to predict a CD morbidity grade ≥ 3 (OR 41.9, p < 0.001). Other factors predictive of CD morbidity grade ≥ 3 included smoking, elevated preoperative platelet count and elevated preoperative neutrophil-lymphocyte ratio (OR 15.6, 8.6, and 6.3 respectively, all p < 0.05). CRP values above 5.5 mg/L were indicative of all-cause morbidity (AUC = 0.871), and values above 17.5 mg/L predicted severe complications (AUC = 0.934). Conclusions Elevated preoperative CRP predicts increased postoperative morbidity in this patient cohort. The results herein aid risk and resource stratification and encourage preoperative assessment of inflammatory propensity besides simple sepsis exclusion.

Sign in / Sign up

Export Citation Format

Share Document