scholarly journals Impact of the change from the seventh to eighth edition of the AJCC TNM classification of malignant tumours and comparison with the MACIS prognostic scoring system in non‐medullary thyroid cancer

BJS Open ◽  
2019 ◽  
Vol 3 (5) ◽  
pp. 623-628 ◽  
Author(s):  
S. Dwamena ◽  
N. Patel ◽  
R. Egan ◽  
M. Stechman ◽  
D. Scott‐Coombes
Keyword(s):  
Thyroid Cancer ◽  
Scoring System ◽  
Medullary Thyroid Cancer ◽  
Tnm Classification ◽  
Malignant Tumours ◽  
Medullary Thyroid ◽  
Eighth Edition

scholarly journals Principles of medullary thyroid cancer staging according to AJCC TNM 8th edition

2021 ◽  
Vol 27 (1-2) ◽  
pp. 101-116
Author(s):  
O.R. Duda ◽  
◽  
R.R. Slipetsky ◽  
N.I. Bojko ◽  
◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Tnm Classification ◽  
Medical Documentation ◽  
Basic Principles ◽  
Adequate Treatment ◽  
Medullary Thyroid ◽  
7Th Edition ◽  
8Th Edition

Aim. The research aims at analyzing the main changes in classification of medullary thyroid cancer and outlining the principles of staging according to modern studies. Material and Methods. Specific scientific articles for the period of 2009-2019 referring to the principles and rules of the TNM classification process, as well as recommendations of the TNM committees of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (IUAC) were selected for the analysis. The basic principles of classification and staging for 8th edition of TNM, as well as changes that have taken place in comparison with 7th edition of TNM It were defined. Results and Discussion. Medullary thyroid cancer accounts for 1-2 percent in the structure of cancers of the thyroid gland, however it is associated with a high mortality rate compared to highly differentiated forms of thyroid cancer. The main radical method of treatment is an adequate volume of surgical intervention, which is determined on the basis of proper staging, the use of visualization methods and the practical experience of doctors. The 7th edition of the TNM was introduced to the scientific society in 2009. It has been 10 years since a new version of the 8th edition based on the new data in evidence-based medicine appeared. It included numerous changes and additions, namely for medullary thyroid cancer. The following research suggests a detailed review and analysis of the basic principles of the staging and classification of medullary thyroid cancer for AJCC TNM-8 in order to improve the diagnosis and treatment of patients with the mentioned above disease. Conclusions. The use of modern principles of classification and staging of medullary thyroid cancer in clinical practice promotes choosing the adequate treatment method and estimating the patient's prognosis. In addition, further improvement of the staging system by TNM-committee and cancer registers depends on the presence of detailed information on additional "parameters for collection and further evaluation" in medical documentation.

TNM classification of gynaecological malignant tumours, eighth edition: changes between the seventh and eighth editions

2019 ◽  
Vol 49 (4) ◽  
pp. 311-320 ◽  
Author(s):  
Hideki Tokunaga ◽  
Muneaki Shimada ◽  
Mitsuya Ishikawa ◽  
Nobuo Yaegashi
Keyword(s):  
Tnm Classification ◽  
Malignant Tumours ◽  
Eighth Edition

Eighth Edition of the UICC Classification of Malignant Tumours: an overview of the changes in the pathological TNM classification criteria—What has changed and why?

2017 ◽  
Vol 472 (4) ◽  
pp. 519-531 ◽  
Author(s):  
Luca Bertero ◽  
Federica Massa ◽  
Jasna Metovic ◽  
Roberto Zanetti ◽  
Isabella Castellano ◽  
...  
Keyword(s):  
Tnm Classification ◽  
Classification Criteria ◽  
Malignant Tumours ◽  
Eighth Edition

scholarly journals Current status of the prognostic molecular markers in medullary thyroid carcinoma

2020 ◽  
Vol 9 (12) ◽  
pp. R251-R263
Author(s):  
Malgorzata Oczko-Wojciechowska ◽  
Agnieszka Czarniecka ◽  
Tomasz Gawlik ◽  
Barbara Jarzab ◽  
Jolanta Krajewska
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Tnm Classification ◽  
Gene Mutations ◽  
Distant Metastases ◽  
Tumor Stage ◽  
Current Status ◽  
Medullary Thyroid ◽  
Long Term Follow Up

Medullary thyroid cancer (MTC) is a rare thyroid malignancy, which arises from parafollicular C-cells. It occurs in the hereditary or sporadic form. Hereditary type is a consequence of activation of the RET proto-oncogene by germline mutations, whereas about 80% of sporadic MTC tumors harbor somatic, mainly RET or rarely RAS mutations. According to the current ATA guidelines, a postoperative MTC risk stratification and long-term follow-up are mainly based on histopathological data, including tumor stage, the presence of lymph node and/or distant metastases (TNM classification), and serum concentration of two biomarkers: calcitonin (Ctn) and carcinoembryonic antigen (CEA). The type of RET germline mutation also correlates with MTC clinical characteristics. The most common and the best known RET mutation in sporadic MTC, localized at codon 918, is related to a more aggressive MTC course and poorer survival. However, even if histopathological or clinical features allow to predict a long-term prognosis, they are not sufficient to select the patients showing aggressive MTC courses requiring immediate treatment or those, who are refractory to different therapeutic methods. Besides the RET gene mutations, there are currently no other reliable molecular prognostic markers. This review summarizes the present data of genomic investigation on molecular prognostic factors in medullary thyroid cancer.

scholarly journals Prognostic Performance of Alternative Lymph Node Classification Systems for Patients with Medullary Thyroid Cancer: A Single Center Cohort Study

2021 ◽  
Author(s):  
Dimitrios Prassas ◽  
Aristodemos Kounnamas ◽  
Kenko Cupisti ◽  
Matthias Schott ◽  
Wolfram Trudo Knoefel ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Regression Models ◽  
Medullary Thyroid Cancer ◽  
Tnm Classification ◽  
Classification Systems ◽  
Discriminative Power ◽  
Medical Database ◽  
Prognostic Performance ◽  
Medullary Thyroid

Abstract Background Lymph node ratio (LNR) and the log odds of positive lymph nodes (LODDS) have been proposed as alternative lymph node (LN) classification schemes. Various cut-off values have been defined for each system, with the question of the most appropriate for patients with medullary thyroid cancer (MTC) still remaining open. We aimed to retrospectively compare the predictive impact of different LN classification systems and to define the most appropriate set of cut-off values regarding accurate evaluation of overall survival (OS) in patients with MTC. Methods 182 patients with MTC who were operated on between 1985 and 2018 were extracted from our medical database. Cox proportional hazards regression models and C-statistics were performed to assess the discriminative power of 28 LNR and 28 LODDS classifications and compare them with the N category according to the 8th edition of the AJCC/UICC TNM classification in terms of discriminative power. Regression models were adjusted for age, sex, T category, focality, and genetic predisposition. Results High LNR and LODDS are associated with advanced T categories, distant metastasis, sporadic disease, and male gender. In addition, among 56 alternative LN classifications, only one LNR and one LODDS classification were independently associated with OS, regardless of the presence of metastatic disease. The C-statistic demonstrated comparable results for all classification systems showing no clear superiority over the N category. Conclusion Two distinct alternative LN classification systems demonstrated a better prognostic performance in MTC patients than the N category. However, larger scale studies are needed to further verify our findings.

Abstract #1101 The Value of Calcitonin Calcium Stimulation Test Levels as Predictors of Medullary Thyroid Cancer.

2018 ◽  
Vol 24 ◽  
pp. 273-274
Author(s):  
Corin Badiu ◽  
Mara Baet ◽  
Ruxandra Dobrescu ◽  
Andra Caragheorgheopol ◽  
Corneci Cristina
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Stimulation Test ◽  
Medullary Thyroid ◽  
Calcium Stimulation

Immunoscintigraphy in Medullary Thyroid Cancer Using an 123I- or 111ln-Labelled Monoclonal Anti-CEA Antibody Fragment

1986 ◽  
Vol 25 (06) ◽  
pp. 227-231 ◽  
Author(s):  
Chr. Eilles ◽  
W. Spiegel ◽  
W. Becker ◽  
W. Börner ◽  
Chr. Reiners
Keyword(s):  
Bone Marrow ◽  
Thyroid Cancer ◽  
Potassium Iodide ◽  
Medullary Thyroid Cancer ◽  
Elevated Serum ◽  
Antibody Fragment ◽  
Special Importance ◽  
Medullary Thyroid ◽  
Medullary Cancer ◽  
Serum Cea

The monoclonal anti-CEA F(ab’)2 fragment MAb BW 431/31, labelled with 123I or111 In, was used for immunoscintigraphy (IS) in 9 patients with medullary cancer of the thyroid (CCC). The results of 11 studies lead to the following conclusions: 1) When using radioiodine as a label for MAb in IS, potassium iodide is absolutely necessary to block the thyroid which is of special importance in patients with thyroid cancer; 2) Preinjection of “cold” MAb reduces the relatively high unspecific uptake (especially in bone marrow) of MAb BW 431/31, which is of special importance for the antibody labelled with 111 In; 3) IS with MAb BW 413/31 in patients with CCC and elevated serum CEA is positive only in cases with large secondaries; and 4) In patients with CCC and several manifestations of secondaries, only a single (large) metastasis may be apparent.

NTRK3 receptor expression is strictly associated with medullary thyroid cancer RET mutation status

2014 ◽  
Author(s):  
Malgorzata Oczko-Wojciechowska ◽  
Michal Swierniak ◽  
Malgorzata Kowalska ◽  
Agnieszka Pawlaczek ◽  
Monika Kowal ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Receptor Expression ◽  
Mutation Status ◽  
Medullary Thyroid ◽  
Ret Mutation
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