Benefits of preoperative MRI in breast cancer surgery studied in a large population-based cancer registry

2015 ◽  
Vol 102 (13) ◽  
pp. 1649-1657 ◽  
Author(s):  
E. L. Vos ◽  
A. C. Voogd ◽  
C. Verhoef ◽  
S. Siesling ◽  
I. M. Obdeijn ◽  
...  
PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0153704 ◽  
Author(s):  
Joanna C. Mennie ◽  
Pari-Naz Mohanna ◽  
Joseph M O’Donoghue ◽  
Richard Rainsbury ◽  
David A. Cromwell

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
E. C. Inwald ◽  
O. Ortmann ◽  
F. Zeman ◽  
M. Koller ◽  
F. Hofstädter ◽  
...  

Even though randomized controlled clinical trials demonstrated improved survival by adjuvant trastuzumab treatment of HER2-positive breast cancer patients, data on its effect in clinical routine are scarce. This study evaluated the use and efficacy of trastuzumab in routine treatment of HER2-positive breast cancer patients. Data from the clinical cancer registry Regensburg (Germany) were analyzed. The present study investigated 6,991 female patients with primary invasive breast cancer. In premenopausal HER2-positive patients a considerable increase of trastuzumab therapy was observed from 58.1% in 2006 to 90.9% in 2011, whereas in postmenopausal patients trastuzumab was rather used on a constant rate of 49.1%. Best overall survival (OS) was found in HER2/steroid hormone receptor-positive patients receiving guideline concordant treatment with trastuzumab plus chemotherapy (CHT) plus antihormone therapy (AHT) with a 7-year OS rate of 96% compared to the non-trastuzumab group with a 7-year OS rate of 92%. In multivariable analysis, HER2-positive patients treated with CHT or AHT who did not get trastuzumab, had a worse 7-year OS (65%,P=0.006versus 79%,P=0.017) than the control groups. This population-based study demonstrated that guideline concordant use of adjuvant trastuzumab improves OS for HER2-positive breast cancer patients treated in routine clinical care.


2013 ◽  
Vol 139 (2) ◽  
pp. 539-552 ◽  
Author(s):  
E. C. Inwald ◽  
M. Klinkhammer-Schalke ◽  
F. Hofstädter ◽  
F. Zeman ◽  
M. Koller ◽  
...  

Pain ◽  
2014 ◽  
Vol 155 (2) ◽  
pp. 232-243 ◽  
Author(s):  
Julie Bruce ◽  
Alison J. Thornton ◽  
Rachael Powell ◽  
Marie Johnston ◽  
Mary Wells ◽  
...  

Author(s):  
Mya L. Roberson ◽  
Hazel B. Nichols ◽  
Stephanie B. Wheeler ◽  
Katherine E. Reeder-Hayes ◽  
Andrew F. Olshan ◽  
...  

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