Comprehensive Geriatric Assessment and predicted 3-year survival in treatment planning for frail patients with early breast cancer

2015 ◽  
Vol 102 (5) ◽  
pp. 525-533 ◽  
Author(s):  
A. Stotter ◽  
M. W. Reed ◽  
L. J. Gray ◽  
N. Moore ◽  
T. G. Robinson
Keyword(s):  
Breast Cancer ◽  
Treatment Planning ◽  
Early Breast Cancer ◽  
Geriatric Assessment ◽  
Comprehensive Geriatric Assessment ◽  
Frail Patients

scholarly journals Comprehensive geriatric assessment in 326 older women with early breast cancer

2017 ◽  
Vol 117 (7) ◽  
pp. 925-931 ◽  
Author(s):  
D O Okonji ◽  
R Sinha ◽  
I Phillips ◽  
D Fatz ◽  
A Ring
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Early Breast Cancer ◽  
Geriatric Assessment ◽  
Comprehensive Geriatric Assessment

Early breast cancer in elderly women: The value of Comprehensive Geriatric Assessment (CGA)

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 8172-8172 ◽  
Author(s):  
G. Albrand ◽  
C. Terret ◽  
H. Mignotte ◽  
S. Gaujard ◽  
J. P. Droz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Geriatric Assessment ◽  
Comprehensive Geriatric Assessment ◽  
Elderly Women

12 Comprehensive geriatric assessment (CGA) in elderly women with early breast cancer

2006 ◽  
Vol 60 ◽  
pp. S28
Author(s):  
R. Gironés ◽  
D. Torregrosa ◽  
J. Torró ◽  
J. Aguiló ◽  
R. Díaz-Beveridge
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Geriatric Assessment ◽  
Comprehensive Geriatric Assessment ◽  
Elderly Women

scholarly journals Comprehensive geriatric assessment for older women with early breast cancer – a systematic review of literature

2012 ◽  
Vol 10 (1) ◽  
pp. 88 ◽  
Author(s):  
Ruth M Parks ◽  
Radhika Lakshmanan ◽  
Linda Winterbottom ◽  
David AL Morgan ◽  
Karen Cox ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Older Women ◽  
Early Breast Cancer ◽  
Geriatric Assessment ◽  
Comprehensive Geriatric Assessment ◽  
Review Of Literature

scholarly journals Comprehensive Geriatric Assessment in Consecutive Newly-Diagnosed Elderly Multiple Myeloma Patients in China: A Multicentered, Prospective, Non-Interventional Study

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 5493-5493
Author(s):  
Yuan Yao ◽  
Dehui Zou ◽  
Aijun Liao ◽  
Xiaoxia Chu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Myeloma ◽  
Clinical Trials ◽  
Cognitive Impairment ◽  
Geriatric Assessment ◽  
Real World ◽  
Comprehensive Geriatric Assessment ◽  
Newly Diagnosed ◽  
Frail Patients

Background: Multiple Myeloma (MM) is a disease of the elderly, whose prognoses are highly heterogeneous. Hence International Myeloma Working Group (IMWG) proposed geriatric assessment (GA) in 2015, including daily activity and comorbidity status, to better discriminate between fit and frail patients (Palumbo et al, 2015). However, IMWG recruited patients from clinical trials instead of real world practices. Therefore we studied GA in elderly MM patients consecutively in China, along with other perspectives which are known to be problematic in elderly population that were previously left unnoticed, such as nutrition status, risk of cognitive impairment, risk of depression, and quality of life. Aim: Our study centers on the feasibility to perform a more comprehensive geriatric assessment (cGA) in elderly MM patients, current cGA status in elderly MM patients in China, and the cGA difference between Chinese patients and patients in the IMWG study. Method: From August 2017 to April 2019, we continuously recruited 336 newly diagnosed elderly (age ≥ 65) MM patients from 21 centers in China. cGA was performed at diagnosis, after treatment cycle 1, after cycle 4, and 1 year after treatment. cGA includes physical conditions (ECOG), activities of daily living (ADL), instrumental ADL (IADL), mini-nutritional assessment (MNA-SF), geriatric depression scale (GDS), mini-mental state examination (MMSE), quality of life (SF-36) and Charlson comorbidity index (CCI). Staging was assessed at baseline (International Staging System (ISS) & Revised ISS) and hematological responses were evaluated along with each cGA timepoint. Results: We pool-analyzed data of 336 newly-diagnosed elderly MM patients. The median age was 70 (range 65-88) and 25.5% of patients were older than 75 years. 336 (100%) patients were able to complete cGA, and median assessment time was 40 minutes (range 20-70). Upon diagnosis, only 34% and 37.5% of patients had full ADL and IADL respectively. 38.5% of patients had moderate to high risk of depression (GDS ≥ 6). 13.2% of patients were malnourished (MNA-SF ≤ 7), while 46.3% of patients were at risk of malnutrition (8 ≤ MNA-SF ≤ 11). 41% of patients had at least one comorbidity (CCI ≥ 1). 45.7% of patients had moderate to intermediate risk of cognitive impairment (MMSE ≤ 26). Grouping by IMWG-GA index, our study identified 59.9% patients in frail group (vs 39% in IMWG study), 15.8% in intermediate (vs 31% in IMWG) and 24.3% in fit (vs 30% in IMWG). 69% of patients received proteasome inhibitor-containing regimens and 20.7% of patients received lenalidomide-containing regimens. Best hematological responses in fit and intermediate groups were better than responses in frail group (≥ PR rate: 88.5% in fit, 94.4% in intermediate vs 77.5% in frail). Median follow up time was 10 months. To date, 215 (64%) patients have finished the cGA after cycle 1; 164 (48.8%) patients have finished the cGA after cycle 4; 91 (27.1%) patients has finished all 4 planned cGA and improvements in cGA were observed in the majority of these patients. Conclusion: Our study showed significant CGA heterogeneity in elderly MM patients. Even in the IMWG-GA "fit" group, nutrition, depression and cognitive impairment remain problems. Frail patients took up a larger proportion in Chinese elderly MM patients compared to IMWG study. Our study strongly justifies the necessity for cGA in elderly patients with MM, more so in the real world MM patients than in the clinical trials. Disclosures No relevant conflicts of interest to declare.

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