Systematic review of the impact of registration and screening on colorectal cancer incidence and mortality in familial adenomatous polyposis and Lynch syndrome

2013 ◽  
Vol 100 (13) ◽  
pp. 1719-1731 ◽  
Author(s):  
P. Barrow ◽  
M. Khan ◽  
F. Lalloo ◽  
D. G. Evans ◽  
J. Hill
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Familial Adenomatous Polyposis ◽  
Lynch Syndrome ◽  
Cancer Incidence ◽  
Adenomatous Polyposis ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence ◽  
The Impact

The impact of screening and genetic registration on mortality and colorectal cancer incidence in familial adenomatous polyposis

Gut ◽  
2010 ◽  
Vol 59 (10) ◽  
pp. 1378-1382 ◽  
Author(s):  
E. K. L. Mallinson ◽  
K. F. Newton ◽  
J. Bowen ◽  
F. Lalloo ◽  
T. Clancy ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Familial Adenomatous Polyposis ◽  
Cancer Incidence ◽  
Adenomatous Polyposis ◽  
Colorectal Cancer Incidence ◽  
The Impact

scholarly journals Colonoscopic screening is associated with reduced Colorectal Cancer incidence and mortality: a systematic review and meta-analysis

2020 ◽  
Vol 11 (20) ◽  
pp. 5953-5970
Author(s):  
Jiaxin Zhang ◽  
Guang Chen ◽  
Zhiguo Li ◽  
Peng Zhang ◽  
Xiaoke Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence

scholarly journals Efficacy and safety of chemopreventive agents on colorectal cancer incidence and mortality: systematic review and network meta-analysis

2018 ◽  
Vol Volume 10 ◽  
pp. 1433-1445 ◽  
Author(s):  
Sajesh K Veettil ◽  
Peerawat Jinatongthai ◽  
Surakit Nathisuwan ◽  
Nattawat Teerawattanapong ◽  
Siew Mooi Ching ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Chemopreventive Agents ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence

scholarly journals Quantifying the impact of adherence to screening strategies on colorectal cancer incidence and mortality

2019 ◽  
Vol 9 (2) ◽  
pp. 824-836 ◽  
Author(s):  
Elvira D’Andrea ◽  
Dennis J. Ahnen ◽  
Daniel A. Sussman ◽  
Mehdi Najafzadeh
Keyword(s):  
Colorectal Cancer ◽  
Cancer Incidence ◽  
Incidence And Mortality ◽  
Screening Strategies ◽  
Colorectal Cancer Incidence ◽  
The Impact

scholarly journals Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e032773 ◽  
Author(s):  
Henriette C Jodal ◽  
Lise M Helsingen ◽  
Joseph C Anderson ◽  
Lyubov Lytvyn ◽  
Per Olav Vandvik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Screening ◽  
Cancer Incidence ◽  
Cancer Mortality ◽  
Meta Analysis ◽  
Randomised Trials ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence ◽  
Colorectal Cancer Mortality

ObjectiveEvaluate effectiveness, harms and burdens of faecal blood testing, sigmoidoscopy and colonoscopy screening for colorectal cancer over 15 years.DesignWe performed an update of a Cochrane systematic review, and performed network meta-analysis comparing randomised trials evaluating colorectal cancer screening with guaiac faecal occult blood test (gFOBT) (annual, biennial), faecal immunochemical test (FIT) (annual, biennial), sigmoidoscopy (once-only) or colonoscopy (once-only) in a healthy population, aged 50–79 years. We conducted subgroup analysis on sex. Follow-up >5 years was required for analysis of colorectal cancer incidence and mortality.Results12 randomised trials proved eligible. Compared with no-screening, we found high certainty evidence for sigmoidoscopy screening slightly reducing colorectal cancer incidence (relative risk (RR) 0.76; 95% confidence interval (CI 0.70 to 0.83) and mortality (RR 0.74; 95% CI 0.69 to 0.80), while gFOBT screening had little or no difference on colorectal cancer incidence, but slightly reduced colorectal cancer mortality (annual: RR 0.69; 95% CI 0.56 to 0.86, biennial: RR 0.88; 95% CI 0.82 to 0.93). No screening test reduced mortality nor incidence by more than six per 1000 screened over 15 years. Sigmoidoscopy had a greater effect in men, for both colorectal cancer incidence (women: RR 0.86; 95% CI 0.81 to 0.92, men: RR 0.75, 95% CI 0.71 to 0.79), and mortality (women: RR 0.85; 95% CI 0.71 to 0.96, men: RR 0.67; 95% CI 0.61 to 0.75) (moderate certainty).ConclusionsIn a 15-year perspective, sigmoidoscopy reduces colorectal cancer incidence, while sigmoidoscopy, annual and biennial gFOBT all reduce colorectal cancer mortality. Sigmoidoscopy may reduce colorectal cancer incidence and mortality more in men than in women.PROSPERO registration numberCRD42018093401.

scholarly journals CP*Trends: An Online Tool for Comparing Cohort and Period Trends Across Cancer Sites

2019 ◽  
Vol 188 (7) ◽  
pp. 1361-1370 ◽  
Author(s):  
Theodore R Holford ◽  
Huann-Sheng Chen ◽  
David Annett ◽  
Martin Krapcho ◽  
Asya Dorogaeva ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Incidence ◽  
Control Strategies ◽  
The United States ◽  
Bronchial Cancer ◽  
Data Set ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence ◽  
New Research ◽  
The Impact

Abstract Cohort or period components of trends can provide a rationale for new research or point to clues on the effectiveness of control strategies. Graphical display of trends guides models that quantify the experience of a population. In this paper, a method for smoothing rates by single year of age and year is developed and displayed to show the contributions of period and cohort to trends. The magnitude of the contribution of period and/or cohort in a model for trends may be assessed by the percentage of deviance explained and the relative contributions of cohort (C) and period (P) individually, known as the C-P score. The method is illustrated using Surveillance, Epidemiology, and End Results data (1975–2014) on lung and bronchial cancer mortality in females and prostate and colorectal cancer incidence in males. Smoothed age-period and age-cohort rates provide a useful first step in studies of etiology and the impact of disease control without imposing a restrictive model. We found that, in this data set, cohort predominates for female lung and bronchial cancer and period predominates for male prostate cancer. However, the effects change with age for male colorectal cancer incidence, indicating an age shift in relevant exposures. These methods are applied on an interactive website for both incidence and mortality at over 20 cancer sites in the United States.

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