Expression of cell adhesion molecules and prognosis in breast cancer

2012 ◽  
Vol 100 (2) ◽  
pp. 252-260 ◽  
Author(s):  
S. Saadatmand ◽  
E. M. de Kruijf ◽  
A. Sajet ◽  
N. G. Dekker-Ensink ◽  
J. G. H. van Nes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules

Cell-adhesion molecules as key mechanisms of tumor invasion: the case of breast cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Carla Luís ◽  
Raquel Soares ◽  
Rúben Fernandes ◽  
Mónica Botelho
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cardiovascular Diseases ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Tumor Invasion ◽  
Malignant Neoplasms ◽  
Major Health Problem ◽  
Major Health ◽  
Mortality And Morbidity

: Cancer is a major health problem worldwide and the second leading cause of death only overcome by cardiovascular diseases. Breast cancer is the leading cause of mortality and morbidity among women and one of the most common malignant neoplasms prompt to metastatic disease. In the present review, the mechanisms of the major cell adhesion molecules involved in tumor invasion are discussed, focusing in the case of breast cancer. A non-systematic updated revision of the literature was performed in order to assemble information regarding the expression of the adhesion cell molecules associated with metastasis.

scholarly journals Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer

Heliyon ◽  
2016 ◽  
Vol 2 (1) ◽  
pp. e00059
Author(s):  
Matthew P.A. Henderson ◽  
Holger Hirte ◽  
Sebastien J. Hotte ◽  
Peter A. Kavsak
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules

scholarly journals Nanoparticles-Facilitated Intracellular Transport of siRNAs against Individual Integrin Subunits Inhibits Growth of Breast Cancer Cells

2021 ◽  
Vol 11 (22) ◽  
pp. 10782
Author(s):  
Maeirah Ashaie ◽  
Ezharul Hoque Chowdhury
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Protein Kinase ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Intracellular Transport ◽  
Mitogen Activated Protein Kinase ◽  
Therapeutic Modality ◽  
Breast Cancer Cell Lines ◽  
Carbonate Apatite

For cells and tissues, cell–cell and cell–extracellular matrix adhesion is important for proliferation, differentiation, and response to mechanical stimuli. This adhesion is provided by various cell adhesion molecules (CAMs). However, in breast cancer, depending upon the type and stage, this adherence is dysregulated where the expression of these cell adhesion molecules is either overregulated or unregulated, triggering essential oncogenic pathways. Thus, to control the invasiveness of tumor cells, and reduce metastasis, regulating the homophilic and heterophilic interaction of these molecules and controlling the essential cell pathways is important. In this study, we targeted critical CAMs- integrins to regulate their aberrated behavior via siRNAs delivery. However, as due to charge repulsion and propensity to be degraded by nucleases prior to reaching the target site, naked siRNAs are unable to cross plasma membrane, use of a suitable carrier vehicle is essential. Thus, we employed carbonate apatite (CA), to deliver the selected siRNAs targeting integrin αv, α6, β1, β3, β4, β5, and β6 subunits to various breast cancer cell lines and 4T1-breast cancer induced murine model. Delivery of individual integrin siRNAs complexed with CA nanoparticles (NPs) reduced cell viability and caused decrease in tumor burden. To check the gene knockdown effects on phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and extracellular signal–regulated kinases/mitogen-activated protein kinase (ERK/MAPK) pathways, Western blot analysis was performed, revealing downregulation of the signaling molecules. Thus, CA-facilitated gene therapy targeting various integrins could poise potential therapeutic modality against breast cancer.

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