Randomized clinical trial of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery

2011 ◽  
Vol 98 (10) ◽  
pp. 1365-1372 ◽  
Author(s):  
D. Roos ◽  
L. M. Dijksman ◽  
H. M. Oudemans-van Straaten ◽  
L. T. de Wit ◽  
D. J. Gouma ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Digestive Tract ◽  
Gastrointestinal Surgery ◽  
Selective Decontamination

scholarly journals Randomized clinical trial of selective decontamination of the digestive tract in elective colorectal cancer surgery (SELECT trial)

2019 ◽  
Vol 106 (4) ◽  
pp. 355-363 ◽  
Author(s):  
G. S. A. Abis ◽  
H. B. A. C. Stockmann ◽  
H. J. Bonjer ◽  
N. van Veenendaal ◽  
M. L. M. van Doorn-Schepens ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Digestive Tract ◽  
Selective Decontamination ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery ◽  
Select Trial

scholarly journals Selective Decontamination of the Digestive Tract to Prevent Postoperative Pneumonia and Anastomotic Leakage after Esophagectomy: A Retrospective Cohort Study

Antibiotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 43
Author(s):  
Robin Janssen ◽  
Frans Van Workum ◽  
Nikolaj Baranov ◽  
Harmen Blok ◽  
Jaap ten Oever ◽  
...  
Keyword(s):  
Cohort Study ◽  
Anastomotic Leakage ◽  
Digestive Tract ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Protective Factor ◽  
Gastrointestinal Surgery ◽  
Surgical Site Infections ◽  
Selective Decontamination ◽  
Postoperative Pneumonia

Infectious complications occur frequently after esophagectomy. Selective decontamination of the digestive tract (SDD) has been shown to reduce postoperative infections and anastomotic leakage in gastrointestinal surgery, but robust evidence for esophageal surgery is lacking. The aim was to evaluate the association between SDD and pneumonia, surgical-site infections (SSIs), anastomotic leakage, and 1-year mortality after esophagectomy. A retrospective cohort study was conducted in patients undergoing Ivor Lewis esophagectomy in four Dutch hospitals between 2012 and 2018. Two hospitals used SDD perioperatively and two did not. SDD consisted of an oral paste and suspension (containing amphotericin B, colistin, and tobramycin). The primary outcomes were 30-day postoperative pneumonia and SSIs. Secondary outcomes were anastomotic leakage and 1-year mortality. Logistic regression analyses were performed to determine the association between SDD and the relevant outcomes (odds ratio (OR)). A total of 496 patients were included, of whom 179 received SDD perioperatively and the other 317 patients did not receive SDD. Patients who received SDD were less likely to develop postoperative pneumonia (20.1% vs. 36.9%, p < 0.001) and anastomotic leakage (10.6% vs. 19.9%, p = 0.008). Multivariate analysis showed that SDD is an independent protective factor for postoperative pneumonia (OR 0.40, 95% CI 0.23–0.67, p < 0.001) and anastomotic leakage (OR 0.46, 95% CI 0.26–0.84, p = 0.011). Use of perioperative SDD seems to be associated with a lower risk of pneumonia and anastomotic leakage after esophagectomy.

Cost-Effectiveness of Perioperative Selective Decontamination of the Digestive Tract versus Placebo in Elective Gastrointestinal Surgery

2012 ◽  
Vol 29 (5) ◽  
pp. 384-390 ◽  
Author(s):  
L.M. Dijksman ◽  
D. Roos ◽  
M.F. Gerhards ◽  
J.G.P. Tijssen ◽  
D.J. Gouma ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Digestive Tract ◽  
Gastrointestinal Surgery ◽  
Selective Decontamination

scholarly journals Randomized clinical trial of fluid and salt restriction compared with a controlled liberal regimen in elective gastrointestinal surgery

2013 ◽  
Vol 100 (13) ◽  
pp. 1739-1746 ◽  
Author(s):  
J. P. Kalyan ◽  
M. Rosbergen ◽  
N. Pal ◽  
K. Sargen ◽  
S. J. Fletcher ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Gastrointestinal Surgery ◽  
Salt Restriction

Systematic review of perioperative selective decontamination of the digestive tract in elective gastrointestinal surgery

2013 ◽  
Vol 100 (12) ◽  
pp. 1579-1588 ◽  
Author(s):  
D. Roos ◽  
L. M. Dijksman ◽  
J. G. Tijssen ◽  
D. J. Gouma ◽  
M. F. Gerhards ◽  
...  
Keyword(s):  
Systematic Review ◽  
Digestive Tract ◽  
Gastrointestinal Surgery ◽  
Selective Decontamination

Selective Decontamination of the Digestive Tract in Gastrointestinal Surgery: Useful in Infection Prevention? A Systematic Review

2013 ◽  
Vol 17 (12) ◽  
pp. 2172-2178 ◽  
Author(s):  
Gabor S. A. Abis ◽  
Hein B. A. C. Stockmann ◽  
Marjolein van Egmond ◽  
Hendrik J. Bonjer ◽  
Christina M. J. E. Vandenbroucke-Grauls ◽  
...  
Keyword(s):  
Systematic Review ◽  
Digestive Tract ◽  
Infection Prevention ◽  
Gastrointestinal Surgery ◽  
Selective Decontamination
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