Randomized clinical trial of Chinese herbal medications to reduce wound complications after mastectomy for breast carcinoma

2010 ◽  
Vol 97 (12) ◽  
pp. 1798-1804 ◽  
Author(s):  
J. Chen ◽  
Q. Lv ◽  
M. Yu ◽  
X. Zhang ◽  
J. Gou
Keyword(s):  
Clinical Trial ◽  
Breast Carcinoma ◽  
Randomized Clinical Trial ◽  
Wound Complications ◽  
Chinese Herbal ◽  
Herbal Medications

Oral Metronidazole and Cefixime as Prophylaxis on Wound Complications of Uncomplicated Appendicitis Following Appendectomy: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Khosro Ayazi ◽  
Arash Mohammadi Tofigh ◽  
Shohra Qaderi ◽  
Farzad Esmaeili Tarki ◽  
Majid Samsami ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Randomized Clinical Trial ◽  
Open Appendectomy ◽  
Perforated Appendicitis ◽  
Prophylactic Antibiotics ◽  
Wound Complications ◽  
Control Group ◽  
Case Group ◽  
And Control

Abstract Backgrounds Without proper use of prophylactic antibiotics, the chance of infection at the site of surgery after appendectomy is around 10 to 30%. Although, in the case of nonperforated appendicitis, the therapeutic use of antibiotic prophylaxis is still contentious. Cephalosporins and Metronidazole has been shown to be effective against anaerobe micro-organisms, and its bioavailability after oral and parenteral administration is comparable. The aim of this research is to compare the incidence of infection-related complications following open appendectomy for nonperforated appendicitis in patients who were given prophylactic antibiotics (Metronidazole and Cephalosporins) either intravenously or orally. Materials & Methods In this randomized clinical trial, the open appendectomy was performed on 200 non-perforated appendicitis cases; 87 females and 113 males, with a mean age of 26 years. Of all the enrolled, 100 cases were given single-dose metronidazole and Cefixime orally (study group), and 100 cases were given single-dose intravenous metronidazole and Ceftriaxone (control group). Results The wound infection incidence did not vary substantially between the two groups. (5% and 7% in the control and case group, respectively, P = 0.552). In addition, the length of hospitalization was also similar between both groups (2.4 and 2.6 days in the in the case and control group, respectively, P = 168). Conclusion All in all, it has been concluded that a single-dose metronidazole and Cefixime taken orally before surgery could bestow impactful prophylactic effects for nonperforated appendicitis cases. Therefore, it could be used instead of the parenteral antibiotics (Intravenous Metronidazole and Ceftriaxone).

Feasibility of Preoperative Chemotherapy With or Without Radiation Therapy in Localized Soft Tissue Sarcomas of Limbs and Superficial Trunk in the Italian Sarcoma Group/Grupo Español de Investigación en Sarcomas Randomized Clinical Trial: Three Versus Five Cycles of Full-Dose Epirubicin Plus Ifosfamide

2015 ◽  
Vol 33 (31) ◽  
pp. 3628-3634 ◽  
Author(s):  
Elena Palassini ◽  
Stefano Ferrari ◽  
Paolo Verderio ◽  
Antonino De Paoli ◽  
Javier Martin Broto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Radiation Therapy ◽  
Soft Tissue ◽  
Randomized Clinical Trial ◽  
Preoperative Chemotherapy ◽  
Soft Tissue Sarcomas ◽  
Phase Iii ◽  
Wound Complications ◽  
Hematologic Toxicity ◽  
Grade 3

Purpose We report on feasibility of preoperative chemotherapy with or without radiation therapy (RT) in the context of a phase III randomized clinical trial involving localized, high-risk, soft tissue sarcomas. Patients and Methods Of 321 eligible patients, 161 were randomly assigned to three preoperative cycles of epirubicin 120 mg/m2 plus ifosfamide 9 g/m2, and 160 were randomly assigned to three preoperative plus two postoperative cycles. Among them, 303 patients were included in this analysis; 169 were male and 134 were female, with a median age of 48 years (range, 15 to 79 years). One hundred fifty-two patients received concurrent RT preoperatively at a total dose of 44 to 50 Gy. Preoperative chemotherapy-related hematologic toxicity and early postoperative complications were reported. The influence of RT, age, and sex on hematologic grade 3 or 4 toxicities and wound complications was analyzed. Chemotherapeutic dose intensity (DI) was analyzed. Results Among the patients, 61.4%, 22.4%, and 23.8% experienced, grade 4 leucopenia, grade 3 or 4 anemia, and grade 3 or 4 thrombocytopenia, respectively. Respective rates were 66.4%, 24.3%, and 31.6% when RT was added preoperatively, and 56.3%, 20.5%, and 15.9% when preoperative chemotherapy was administered alone. Patient age affected grade 3 or 4 thrombocytopenia. Grade 4 leucopenia and grade 3 or 4 anemia presented 2.5 times more frequently in female patients than in male patients. Wound complications were observed in 13.5% of patients: 17% with preoperative RT and 10% without. Chemotherapeutic DI was greater than 90%, even in patients receiving preoperative RT and in patients age 65 years or older. Conclusion This preoperative chemotherapy is feasible and can also be proposed for selected elderly patients. Grade 3 or 4 hematologic toxicity was common, but DI was excellent. Concurrent preoperative RT is safe, although an increased rate of grade 4 thrombocytopenia and limited increase in wound complications may be observed.

Wound complications at the groin after peripheral arterial surgery sparing the lymphatic tissue: a double-blind randomized clinical trial

2009 ◽  
Vol 197 (6) ◽  
pp. 747-751 ◽  
Author(s):  
Arianne J. Ploeg ◽  
Jan-Willem P. Lardenoye ◽  
Mark-Paul F.M. Vrancken Peeters ◽  
Jaap F. Hamming ◽  
Paul J. Breslau
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Wound Complications ◽  
Lymphatic Tissue ◽  
Double Blind ◽  
Peripheral Arterial

Role of subcutaneous closure in preventing wound complications after cesarean delivery with Pfannenstiel incision: A randomized clinical trial

2013 ◽  
Vol 40 (3) ◽  
pp. 728-735 ◽  
Author(s):  
Aytul Corbacioglu Esmer ◽  
Pinar Cilesiz Goksedef ◽  
Aysu Akca ◽  
Ozgur Akbayir ◽  
Hediye Dagdeviren ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Cesarean Delivery ◽  
Wound Complications ◽  
Pfannenstiel Incision
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