Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer

2009 ◽  
Vol 96 (5) ◽  
pp. 462-472 ◽  
Author(s):  
W. S. Tan ◽  
C. L. Tang ◽  
L. Shi ◽  
K. W. Eu
Keyword(s):  
Rectal Cancer ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Meta Analysis

scholarly journals Protective Diversion Stoma in Low Anterior Resection for Rectal Cancer: A Meta-Analysis of Randomized Controlled Trials

2019 ◽  
Vol 35 (3) ◽  
pp. 156-160 ◽  
Author(s):  
Pankaj Kumar Garg ◽  
Aakanksha Goel ◽  
Sneha Sharma ◽  
Nilokali Chishi ◽  
Manish Kumar Gaur
Keyword(s):  
Rectal Cancer ◽  
Randomized Controlled Trials ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Diversion Stoma

Meta-analysis of reconstruction techniques after low anterior resection for rectal cancer

2015 ◽  
Vol 102 (7) ◽  
pp. 735-745 ◽  
Author(s):  
F. J. Hüttner ◽  
S. Tenckhoff ◽  
K. Jensen ◽  
L. Uhlmann ◽  
Y. Kulu ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Meta Analysis

scholarly journals Risk factors for major low anterior resection syndrome: meta-analysis and systematic literature review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Evgeny A. Khomyakov ◽  
Islam O. Nafedzov ◽  
Oksana Y. Fomenko ◽  
Mikhail V. Alekseyev ◽  
Sergey A. Frolov ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Statistical Analysis ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Meta Analysis ◽  
Anastomotic Leaks ◽  
Functional Impairments ◽  
Low Anterior Resection Syndrome ◽  
Anterior Resection Syndrome

Introduction — Low anterior resection syndrome (LARS) is a socially significant problem that impedes social adaptation and contributes to deterioration of life quality in patients. The objective of this study was to search for the category of patients most prone to major LARS, as well as to identify the factors determining the severity of this syndrome manifestations. Material and Methods — Systematic review and meta-analysis were performed according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The study selected publications that included the functional results of treatment of patients operated for rectal cancer. Functional impairments were assessed according to the international LARS Score. Statistical analysis was performed using the inverse-variance weighted average method (IVW) with calculation of the odds ratio logarithm and standard error of the mean. Results — After a critical search and analysis of all literature sources, eight studies were found suitable for meta-analysis. In total, 1042 patients (796 men and 246 women) were included into statistical analysis, 409 of which (39.2%) had symptoms of major LARS. Chemotherapy was performed on 637 (62.5%) patients, while 568 subjects (55.5%) underwent radiation therapy, and anastomotic leaks were described in 89 (8.5%) people. According to the results of the meta-analysis, statistically significant factors were: preventative ostomy (OR=3.32, 95% CI 1.99-5.55, p<0.00001), chemotherapy (OR=1.98, 95% CI 1.23-3, 19, p=0.005), radiation therapy (OR=5.00, 95% CI 2.73-9.13, p <0.00001), anastomotic leaks (OR=2.93, 95% CI 2.30-3, 73, p<0.00001), anal verge distance from anastomosis site (OR=2.61, 95% CI 1.47-4.62, p=0.001). Conclusion — The results of our meta-analysis allowed us identifying the group of rectal cancer patients most vulnerable to LARS. The risk of developing severe functional disorders is significantly higher in patients with low colorectal anastomosis, as well as in patients undergoing neoadjuvant radiation therapy.

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