A confirmed association between an ER-ß polymorphic locus and refuted associations in TIMP-1 and MMP-9 with AAA

2009 ◽  
Vol 96 (S1) ◽  
pp. 13-13
Author(s):  
H. S. Rayt ◽  
M. J. Bown ◽  
N. J. London ◽  
R. D. Sayers
Keyword(s):  
Polymorphic Locus

Lack of association of the polymorphic locus in the 5'-flanking region of the human insulin gene and diabetes in American blacks

Diabetes ◽  
1985 ◽  
Vol 34 (5) ◽  
pp. 433-439 ◽  
Author(s):  
S. Elbein ◽  
P. Rotwein ◽  
M. A. Permutt ◽  
G. I. Bell ◽  
N. Sanz ◽  
...  
Keyword(s):  
Human Insulin ◽  
Polymorphic Locus ◽  
Insulin Gene ◽  
Human Insulin Gene ◽  
Flanking Region ◽  
American Blacks

A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library

1986 ◽  
Vol 74 (4) ◽  
pp. 425-431 ◽  
Author(s):  
L. Bufton ◽  
T. K. Mohandas ◽  
R. E. Magenis ◽  
R. Sheehy ◽  
R. K. Bestwick ◽  
...  
Keyword(s):  
Polymorphic Locus ◽  
Cosmid Library ◽  
Chromosome 16Q

Saccharomyces cerevisiae SSD1-VConfers Longevity by a Sir2p-Independent Mechanism

Genetics ◽  
2004 ◽  
Vol 166 (4) ◽  
pp. 1661-1672 ◽  
Author(s):  
Matt Kaeberlein ◽  
Alex A Andalis ◽  
Gregory B Liszt ◽  
Gerald R Fink ◽  
Leonard Guarente
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Life Span ◽  
Cell Cycle Progression ◽  
Polymorphic Locus ◽  
Cell Integrity ◽  
Cycle Progression ◽  
Cellular Processes ◽  
Maximal Life Span ◽  
Independent Mechanism ◽  
Yeast Aging

AbstractThe SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to attain maximal life span. Past studies of yeast aging have been performed in short-lived ssd1-d strain backgrounds. We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains.

A New Multilocus Probe for DNA Fingerprinting in Chinook Salmon (Oncorhynchus tshawytscha), and Comparisons with a Single-Locus Probe

1993 ◽  
Vol 50 (7) ◽  
pp. 1559-1567 ◽  
Author(s):  
T. A. Stevens ◽  
R. E. Withler ◽  
S. H. Goh ◽  
T. D. Beacham
Keyword(s):  
Chinook Salmon ◽  
Oncorhynchus Tshawytscha ◽  
Polymorphic Locus ◽  
Pedigree Analysis ◽  
Single Locus ◽  
Dna Fingerprint ◽  
Dna Fragments ◽  
Banding Patterns ◽  
Discriminatory Ability ◽  
Juvenile Chinook Salmon

A multilocus DNA probe, B2-2, isolated from chinook salmon (Oncorhynchus tshawytscha) and a single-locus Atlantic salmon (Salmo salar) probe, 3.15.34, were examined for discriminatory ability among seven parents and 33–37 juveniles from five families of chinook salmon. DNA fingerprint patterns were observed in Hae III-digested chinook salmon DNA probed with B2-2. Between 8 and 20 fragments, from 2.20 kilobase pairs (kbp) to 19.0 kbp, were detected in each individual. The level of band sharing among unrelated parents was 0.18. Probe 3.15.34 hybridized with a total of nine DNA fragments, from 3.35 to 6.00 kbp, in the chinook salmon parents and progeny. One or two fragments were detected in each individual. Pedigree analysis confirmed that 3.15.34 detected both alleles of a single polymorphic locus whereas B2-2 detected autosomal, unlinked, predominantly heterozygous DNA fragments that were inherited in a Mendelian fashion at a minimum of 10 polymorphic loci. Among juvenile chinook salmon, levels of band sharing detected with probe B2-2 increased with increasing relatedness, and clustering based on differences in banding patterns distinguished unrelated progeny, half sibs, and full sibs even in the absence of parental genotypic data.

Role of the c825t polymorphic locus of G-protein beta subunit (GNBβ3) in patients with gastroesophageal reflux disease

Therapy ◽  
2021 ◽  
Vol 9_2021 ◽  
pp. 46-50
Author(s):  
Zhilina A.A. Zhilina ◽  
Lareva N.V. Lareva ◽  
Luzina E.V. Luzina ◽  
Zhigula Z.M. Zhigula Z ◽  
Tomina E.A. Tomina ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
G Protein ◽  
Reflux Disease ◽  
Polymorphic Locus ◽  
Beta Subunit

scholarly journals A polymorphic locus [D21S144] is detected by probe pVC12 on chromosome 21

1989 ◽  
Vol 17 (11) ◽  
pp. 4420-4420 ◽  
Author(s):  
Guy Van Camp ◽  
Piet Stinissen ◽  
Antoon Vandenberghe ◽  
Christine Van Broeckhoven
Keyword(s):  
Polymorphic Locus ◽  
Chromosome 21

scholarly journals GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT

2018 ◽  
Vol 20 (5) ◽  
pp. 739-746
Author(s):  
O. V. Kochetova ◽  
L. Z. Akhmadishina ◽  
G. F. Korytina ◽  
Т. V. Victorova
Keyword(s):  
Body Weight ◽  
Glucose Level ◽  
Acute Phase ◽  
Chemokine Receptors ◽  
Acute Phase Proteins ◽  
Fasting Glucose ◽  
Polymorphic Locus ◽  
Control Group ◽  
Polymorphism Analysis ◽  
Fasting Glucose Level

In the present study, we have investigated frequency of genotypes and functional alleles of genes encoding chemokines (CXCL12 rs1801157, CCL2 rs1024611), chemokine receptors (CCR5 del32, CX3CR1 rs3732378), acute phase proteins SAA rs1136743, and CD14 rs2569190 polymorphisms among Tatar obese or overweight women from the Republic of Bashkortostan.The group of patients comprised unrelated women with obesity (BMI ≥ 30 kg/m2, n = 225), females with overweight (BMI 25.0-29.9 kg/m2, n = 184), and control group of women (n = 327) BMI < 25.0 kg/m2. Genotyping was performed by PCR-RFLP analysis. Patients and controls differed in such parameters as body weight (p = 0.00001), BMI level (p = 0.001) and fasting glucose level (p = 0.0001).An association was revealed between obesity andAG-AAgenotypes (p = 0.007) andAallele (p = 0.003) of polymorphic locus rs3732378 ofCXCR1gene, as well asTTgenotype (p = 0.027) andTallele (p = 0.021) of polymorphic locus rs1136743 ofSAAgene. It has been shown that theAAgenotype of polymorphic locus rs3732378 of theCX3CR1gene is associated with increased body weight (p = 0.002) and elevated BMI (p = 0.018); theGGgenotype of polymorphic locus rs1024611 of theCCL2gene is associated with elevated fasting glucose level (p = 0.001).As based on clinical and genetic data and using logistic regression, some statistically significant differences were revealed, which allow to predict development of obesity in Tatar women.

scholarly journals The efficacy of diuretics in complex treatment of patients with hypertension according to the Gly460Trp polymorphism of the α-adducin gene

2021 ◽  
Vol 23 (4) ◽  
pp. 503-508
Author(s):  
S. A. Yermolenko ◽  
V. F. Orlovskyi ◽  
O. V. Orlovskyi ◽  
A. V. Zharkova ◽  
I. O. Moiseienko ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Gene Polymorphism ◽  
Polymorphic Locus ◽  
Polymorphic Marker ◽  
Individual Treatment ◽  
Healthy Individuals ◽  
Group I ◽  
Allelic Distribution ◽  
Pcr Rflp ◽  
Polymerase Chain

The aim of the study was to investigate the effect of thiazide diuretics on blood pressure (BP) depending on Gly460Trp ADD1 gene polymorphism in arterial hypertension (AH) patients of the Ukrainian population in order to predict their individual treatment efficacy. Material and methods. The study included 232 persons: 120 patients with verified stage II AH and 112 healthy individuals. Restriction fragment length polymerase chain reaction (PCR-RFLP) was used to detect genotype (the Gly460Trp-polymorphic locus of the ADD1 gene). The patients received standard therapy, which included ACE inhibitor – ramipril 5 mg, calcium channel antagonist – amlodipine 5 mg, statin – atorvastatin 20 mg, acetylsalicylic acid 75 mg. The patients were randomized into two groups: group I (60 persons) additionally taking treatment with 1.5 mg of indapamide retard and group II (60 persons) – with 25 mg of hydrochlorothiazide. The dynamic reduction of blood pressure has been assessed every 4 weeks for 2 months. Results. Among 120 patients with AH, 91 persons (75.8 %) were homozygous for the G allele (GG), 26 persons (21.7 %) – heterozygous (GT) and 3 persons (2.5 %) – homozygous for the T allele (TT), while the G allele frequency in patients with hypertension was 0.87, and the T allele – 0.13. 98 healthy individuals (87.5 %) were homozygous for the G allele, 13 individuals (11.6 %) were heterozygous, and 1 person (0.9 %) was homozygous for the T allele. The carrier frequency of the G and T alleles was 0.93 and 0.07, respectively. Allelic distribution indicated the predominance of the G allele carriers by Gly460Trp polymorphism of the ADD1 gene among the Ukrainian population, regardless of whether AH symptoms were present. It is noteworthy that the number of the T allele carriers was 2 times large among symptomatic patients than that among healthy individuals. In patients with the T allele, the hypotensive efficacy of indapamide was almost 3 times higher than that in patients with the G allele. The antihypertensive effect of hydrochlorothiazide in patients with the GT and TT genotypes was 2 times greater than that in the GG genotype carriers depending on the presence of the T allele G460T polymorphism of ADD1 gene in the genotype. Conclusions. Allelic distribution indicates the predominance of the G allele carriers by Gly460Trp ADD1 gene polymorphism among the Ukrainian population, regardless of whether AH symptoms are present. Among patients with AH, the accumulation of the T allele G460T polymorphic marker of the α-adducin gene is 2 times more than that in healthy individuals. Patients carrying the T allele demonstrate 2 times higher hypotensive efficacy of indapamide compared with hydrochlorothiazide.

scholarly journals Allele frequency divergence reveals ubiquitous influence of positive selection in Drosophila

2021 ◽  
Author(s):  
Jason Bertram
Keyword(s):  
Allele Frequency ◽  
Evolutionary Biology ◽  
Polymorphic Locus ◽  
Purifying Selection ◽  
Allele Frequencies ◽  
Intermediate Allele ◽  
Genome Wide ◽  
Signature Of Selection ◽  
Basic Objective ◽  
Genomic Regions

Resolving the role of natural selection is a basic objective of evolutionary biology. It is generally difficult to detect the influence of selection because ubiquitous non-selective stochastic change in allele frequencies (genetic drift) degrades evidence of selection. As a result, selection scans typically only identify genomic regions that have undergone episodes of intense selection. Yet it seems likely such episodes are the exception; the norm is more likely to involve subtle, concurrent selective changes at a large number of loci. We develop a new theoretical approach that uncovers a previously undocumented genome-wide signature of selection in the collective divergence of allele frequencies over time. Applying our approach to temporally-resolved allele frequency measurements from laboratory and wild Drosophila populations, we quantify the selective contribution to allele frequency divergence and find that selection has substantial effects on much of the genome. We further quantify the magnitude of the total selection coefficient (a measure of the combined effects of direct and linked selection) at a typical polymorphic locus, and find this to be large (of order 1%) even though most mutations are not directly under selection. We find that selective allele frequency divergence is substantial at intermediate allele frequencies, which we argue is most parsimoniously explained by positive --- not purifying --- selection. Thus, in these populations most mutations are far from evolving neutrally in the short term (tens of generations), including mutations with neutral fitness effects, and the result cannot be explained simply as a purging of deleterious mutations.

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