Intra-anal application ofL-erythro methoxamine gel increases anal resting pressure in patients with incontinence

2007 ◽  
Vol 94 (9) ◽  
pp. 1155-1161 ◽  
Author(s):  
P. J. Nisar ◽  
H.-J. Gruss ◽  
D. Bush ◽  
A. G. Acheson ◽  
J. H. Scholefield
Keyword(s):  
Resting Pressure ◽  
Anal Resting Pressure

Spontaneous variation of anal "resting" pressure in healthy humans

1991 ◽  
Vol 261 (5) ◽  
pp. G823-G826
Author(s):  
P. Enck ◽  
E. Eggers ◽  
S. Koletzko ◽  
J. F. Erckenbrecht
Keyword(s):  
Anal Sphincter ◽  
Dynamic Structure ◽  
Anal Pressure ◽  
Cyclic Activity ◽  
Healthy Humans ◽  
Resting Pressure ◽  
Defecation Disorders ◽  
Anal Resting Pressure ◽  
Transducer Probe

To investigate anal sphincter performance during sleep and after a meal, a two-channel micro-transducer probe was used for 12-h stationary recording of basal anal pressure overnight in eight healthy male volunteers. It was shown that the basal anal pressure ("resting" pressure) exhibits three distinct patterns of cyclic activity changes in all subjects: a long-term rhythm with a prominent decrease of pressure during which sleep was approximately circadian, an ultradian rhythm of approximately 20 to 40 min in length that was more prominent at night, and spontaneous relaxations of the sphincter tone occurring between 3 and 20 times per hour with the maximum frequency after breakfast. These data indicate that the anal sphincter is a dynamic structure not often at rest. Long-term anorectal manometry may be supplementary to short-term clinical evaluation of anal sphincter performance in healthy subjects as well as in patients with defecation disorders.

T1351 The Effect of Electronic Cleansing Toilet System (Bidet) on Anal Resting Pressure in Normal Healthy Volunteers

2010 ◽  
Vol 138 (5) ◽  
pp. S-543
Author(s):  
Seungbum Ryoo ◽  
Yoon Suk Song ◽  
Mi Sun Seo ◽  
Sung Lyul Park ◽  
Sun Dug Kwon ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Resting Pressure ◽  
Anal Resting Pressure

scholarly journals Myoxinol (HydrolyzedHibiscus esculentusExtract) in the Cure of Chronic Anal Fissure: Early Clinical and Functional Outcomes

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Adolfo Renzi ◽  
Antonio Brillantino ◽  
Giandomenico Di Sarno ◽  
Francesco D’Aniello ◽  
Stefania Ziccardi ◽  
...  
Keyword(s):  
Anal Fissure ◽  
Topical Application ◽  
Chronic Anal Fissure ◽  
Early Results ◽  
Local Product ◽  
Resting Pressure ◽  
Hibiscus Esculentus ◽  
Anal Resting Pressure ◽  
Lost To Follow Up

Objective.This study was designed to evaluate the early results of the topical application of HydrolyzedHibiscus esculentusExtract 3% ointment (Myoxinol 3%), a novel local product with Botox-like activity, in the conservative treatment of chronic anal fissure (CAF).Methods.Among all patients with CAF observed during the study period, 31 subjects met the inclusion criteria and underwent medical therapy with Myoxinol 3% ointment every 12 hours for 6 weeks. Two patients were lost to follow-up. Clinical and manometric follow-up was carried out eight weeks after treatment.Results.At follow-up the success rate was 72.4% (21/29); median VAS score and mean anal resting pressure were significantly lower if compared with respective baseline data. The only one adverse effect of the topical application of Myoxinol 3% ointment was perianal itch, which was reported by 3,4% (1/29) of the patients available for the analysis. However, in this case this symptom did not cause interruption of the treatment.Conclusions.The topical application of Myoxinol 3% ointment in the cure of CAF shows encouraging early results. Further researches with a larger series and a longer follow-up are needed to confirm these data.

scholarly journals HIGH-RESOLUTION ANORECTAL MANOMETRY IN TESTING ANORECTAL FUNCTION AFTER COMBINATION TREATMENT FOR RECTAL CANCER

2020 ◽  
Vol 66 (4) ◽  
pp. 385-390
Author(s):  
Oleg Kit ◽  
Yuriy Gevorkyan ◽  
Natalya Soldatkina ◽  
Yevgeniy Kolesnikov ◽  
Mikhail Averkin ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Surgical Treatment ◽  
Combination Treatment ◽  
Anorectal Manometry ◽  
External Sphincter ◽  
Anorectal Function ◽  
Lars Score ◽  
Resting Pressure ◽  
Anal Resting Pressure

The purpose of the study was to evaluate anorectal function with high-resolution anorectal manometry in patients receiving combination treatment for rectal cancer. Material and methods. We analyzed literature data (PubMed, Scopus, eLIBRARY databases) and our treatment outcomes in 50 rectal cancer patients receiving combination or surgical treatment at Rostov Research Institute of Oncology. Results. The mean anal resting pressure was 1.8 times lower, and the maximal anal squeeze pressure was 1.5 times lower in patients after combination treatment, compared to surgical treatment (p<0.05). 3 months after combination treatment with prolonged radiotherapy, contractile properties of the internal sphincter were decreased in 83.3%, of the external sphincter - in 26.7% of patients. Fatigue rate of external sphincter muscles was increased in 17 (56.7%) patients of this group. We observed a correlation between some anorectal manometry data and the LARS score: in both groups, patients with the maximal LARS score showed the lowest mean anal resting pressure, compared to patients with minimal and average LaRs scores (p<0.05). Conclusion. Due to negative effect of radiation therapy on the anorectal function, careful selection of patients who will benefit from radiation therapy is very important, as well as identification of patients with a high risk of radiation-induced functional problems and development of rehabilitation programs for patients treated for rectal cancer.

Increased anal resting pressure and rectal sensitivity in crohnʼs disease

2003 ◽  
Vol 46 (12) ◽  
pp. 1685-1689 ◽  
Author(s):  
Peter Andersson ◽  
Gunnar Olaison ◽  
Olof Hallböök ◽  
Bernt Boeryd ◽  
Rune Sjödahl
Keyword(s):  
Resting Pressure ◽  
Anal Resting Pressure

Effect of continuous rectal distention on anal resting pressure

2001 ◽  
Vol 44 (5) ◽  
pp. 672-676 ◽  
Author(s):  
Anna Mularczyk ◽  
Paolo A. Bianchi ◽  
Guido Basilisco
Keyword(s):  
Resting Pressure ◽  
Anal Resting Pressure ◽  
Rectal Distention

scholarly journals Effect of nifedipine on anorectal sensorimotor functions in health and fecal incontinence

2011 ◽  
Vol 301 (1) ◽  
pp. G175-G180 ◽  
Author(s):  
Adil E. Bharucha ◽  
Jessica Edge ◽  
Alan R. Zinsmeister
Keyword(s):  
Fecal Incontinence ◽  
Calcium Channels ◽  
Contractile Response ◽  
Plasma Concentrations ◽  
Sinusoidal Oscillation ◽  
Rectal Sensation ◽  
Before And After ◽  
Resting Pressure ◽  
Pressure Increment ◽  
Anal Resting Pressure

The mechanisms of increased rectal stiffness in women with fecal incontinence (FI) and rectal urgency are not understood. Our hypothesis was that distention-induced activation of mechanosensitive L-type calcium channels in smooth muscle contributes to increased rectal stiffness in FI. Anal pressures, rectal distensibility (compliance, capacity, and contractile response to sinusoidal oscillation), and rectal sensation were assessed before and after oral nifedipine (30 + 10 mg) or placebo in 16 women with FI and 16 asymptomatic women. At baseline, FI patients had a lower anal pressure increment during squeeze (health, 66.9 ± 7.6: FI, 28.6 ± 5.9, mean ± SE, P ≤ 0.01), lower rectal capacity ( P = 0.052), and higher rectal pressures during sinusoidal oscillation (health, 13.7 ± 3.2: FI, 21.7 ± 1.4, mean ± SE, P = 0.02) than the healthy women, which suggests an exaggerated rectal contractile response to distention. Nifedipine decreased mean BP, increased heart rate ( P = 0.01 vs. placebo), and reduced anal resting pressure ( P ≤ 0.01) but did not significantly modify rectal distensibility in health or FI. Plasma nifedipine concentrations (health, 103 ± 21 ng/ml: FI, 162 ± 34 ng/ml) were correlated with increased rectal compliance ( r = 0.6, P = 0.02) in all study participants and, in healthy subjects, with decreased rectal pressures during sinusoidal oscillation ( r = 0.86, P = 0.01), indicative of reduced stiffness. No consistent effects on rectal perception were observed. These observations confirm that FI is associated with anal weakness and increased rectal stiffness. At therapeutic plasma concentrations, nifedipine reduced anal resting pressure but did not improve rectal distensibility in FI, outcomes that argue against a predominant contribution of myogenic L-type calcium channels to reduced rectal distensibility in FI.

scholarly journals Pharmacokinetic Characteristics of a Nifedipine and Lidocaine Fixed Combination in the Form of Rectal Cream: Two Decades Data Analysis

2021 ◽  
Vol 5 (1) ◽  
pp. 27-36
Author(s):  
Raffaele Ottaiano ◽  
Mara Sebastiano ◽  
Larysa Bondarenko ◽  
Oleksandra Iudina
Keyword(s):  
Channel Blocker ◽  
Fixed Combination ◽  
Oral Route ◽  
Systemic Absorption ◽  
Active Ingredients ◽  
Relieve Pain ◽  
Rectal Route ◽  
Resting Pressure ◽  
Anal Resting Pressure ◽  
Complementary Actions

The creation of medicines' fixed combinations from compounds with complementary effects is one of the most popular directions in modern pharmacology and pharmaceutics. In case of nifedipine and lidocaine fixed combination such approach is quite obvious. The present review article is devoted to the analysis of clinical and non-clinical studies results on the assessment of the pharmacokinetic characteristics of these medicines. Although the oral route is the most convenient for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local and systemic actions. Research data of last decades suggested that nifedipine, a calcium channel blocker, could be effective in reducing anal resting pressure and in healing chronic anal fissure and acute thrombosed hemorrhoids. Another component of fixed combination lidocaine is a local anesthetic usually used to relieve pain of anal fissures and symptomatic hemorrhoids. In combinations lidocaine and nifedipine have complementary actions. Analysis of all available studies (during last 2 decades) which were aimed to investigate pharmacokinetic characteristics of a nifedipine and lidocaine fixed combination in the form of rectal cream showed that following topical application, the active ingredients nifedipine and lidocaine are absorbed into the bloodstream in only small quantities that have no major implications for the safety of the product, and systemic absorption, if any, was incomparably lower than absorption following per os administration of the two active ingredients.

Sign in / Sign up

Export Citation Format

Share Document