Role of circulating tumour cells in predicting recurrence after excision of primary colorectal carcinoma

2007 ◽  
Vol 94 (1) ◽  
pp. 96-105 ◽  
Author(s):  
T. G. Allen-Mersh ◽  
T. K. McCullough ◽  
H. Patel ◽  
R. Q. Wharton ◽  
C. Glover ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumour Cells ◽  
Circulating Tumour Cells

scholarly journals Enumeration, characterisation and clinicopathological significance of circulating tumour cells in patients with colorectal carcinoma

2021 ◽  
Vol 254-255 ◽  
pp. 48-57
Author(s):  
Faysal Bin Hamid ◽  
Cu-Tai Lu ◽  
Marco Matos ◽  
Tracie Cheng ◽  
Vinod Gopalan ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Clinicopathological Significance

scholarly journals Genetic Heterogeneity of Single Circulating Tumour Cells in Colorectal Carcinoma

2020 ◽  
Vol 21 (20) ◽  
pp. 7766
Author(s):  
Faysal Bin Hamid ◽  
Vinod Gopalan ◽  
Marco Matos ◽  
Cu-Tai Lu ◽  
Alfred King-yin Lam
Keyword(s):  
Gene Expression ◽  
Colorectal Carcinoma ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Genetic Profiling ◽  
Gapdh Gene ◽  
Colon Carcinoma Cells ◽  
Single Ctcs

The aim of the present study was to isolate and investigate the genetic heterogeneities in single circulating tumour cells (CTCs) from patients with colorectal carcinoma (CRC). Twenty-eight single CTCs were collected from eight patients with CRC using a negative immunomagnetic enrichment method. After validation with glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene expression in 3 colon cancer cell lines, a panel of 19 genes were used to analyse the single CTCs (n = 28), primary colorectal carcinoma tissues (n = 8) and colon carcinoma cells (n = 6) using real-time qPCR. Genetic heterogeneities were assessed by comparing gene expression profiles of single CTCs from the different patients and in the same patient, respectively. Genetic profiling of the single CTCs showed extensive heterogeneities of the selected genes among the CTCs. Hierarchical clustering analyses exhibited two clusters of CTCs with differentially expressed genes, which highlighted different modifications from the primary carcinomas. Further, the genetic heterogeneities were observed between different patients or in the same patient. Finally, AKT1 expression was significantly (p = 0.0129) higher in single CTCs from CRC of advanced pathological stages (III or IV) CRC than in CTCs from CRC of early stages (I or II). Our findings suggest that single-cell genetic analysis can monitor the genetic heterogeneities and guide the personalised therapeutic targets in clinical sectors.

scholarly journals The role of disseminated and circulating tumour cells in breast cancer

2006 ◽  
Vol 9 (02) ◽  
Author(s):  
D. Auer ◽  
A. Schneitter ◽  
C. Marth ◽  
S. Braun
Keyword(s):  
Breast Cancer ◽  
Tumour Cells ◽  
Circulating Tumour Cells

scholarly journals Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells

2020 ◽  
Vol 122 (7) ◽  
pp. 1059-1067
Author(s):  
Carlos Alberto Aya-Bonilla ◽  
Michael Morici ◽  
Xin Hong ◽  
Ashleigh Cavell McEvoy ◽  
Ryan Joseph Sullivan ◽  
...  
Keyword(s):  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Prognostic Role ◽  
Heterogeneous Populations

scholarly journals The role of circulating tumour cells and nucleic acids in blood for the detection of bladder cancer: A systematic review

2018 ◽  
Vol 66 ◽  
pp. 56-63 ◽  
Author(s):  
Pramit Khetrapal ◽  
Matthew Wei Liang Lee ◽  
Wei Shen Tan ◽  
Liqin Dong ◽  
Patricia de Winter ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bladder Cancer ◽  
Nucleic Acids ◽  
Tumour Cells ◽  
Circulating Tumour Cells
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