Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia–reperfusion injury

2006 ◽  
Vol 93 (6) ◽  
pp. 752-761 ◽  
Author(s):  
R. Cursio ◽  
N. Filippa ◽  
C. Miele ◽  
E. Van Obberghen ◽  
J. Gugenheim
Keyword(s):  
Protein Kinase ◽  
Reperfusion Injury ◽  
Protein Kinases ◽  
Protein Kinase B ◽  
Ischaemia Reperfusion Injury ◽  
Mitogen Activated Protein Kinases ◽  
Ischaemia Reperfusion ◽  
Mitogen Activated Protein ◽  
Liver Ischaemia

scholarly journals Anti-Melanogenic Effects of Bergamottin via Mitogen-Activated Protein Kinases and Protein Kinase B Signaling Pathways

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1986210
Author(s):  
You Chul Chung ◽  
Yun Beom Kim ◽  
Bong Seok Kim ◽  
Chang-Gu Hyun
Keyword(s):  
Protein Kinase ◽  
Protein Kinases ◽  
Protein Kinase B ◽  
Positive Control ◽  
Akt Inhibitor ◽  
Mitogen Activated Protein Kinases ◽  
Melanocyte Stimulating Hormone ◽  
B16f10 Cells ◽  
Extracellular Signal ◽  
Mitogen Activated Protein

In this study, we examined the inhibitory effects of bergamottin on melanogenesis in B16F10 murine melanoma cells, together with its effects on the mechanism of melanin synthesis. α-Melanocyte stimulating hormone-stimulated B16F10 cells were treated with various concentrations of bergamottin, with arbutin as a positive control. Bergamottin significantly decreased the melanin content and tyrosinase activity without showing any cytotoxicity. In addition, bergamottin treatment significantly downregulated the expression of tyrosinase-related protein-1,2 and tyrosinase by suppressing the expression of microphthalmia-associated transcription factor. The phosphorylation status of mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) was examined to determine the mechanism underlying the antimelanogenic effects of bergamottin. Bergamottin treatment increased the phosphorylation of extracellular signal-regulated kinase (ERK) and AKT, but decreased the phosphorylation of p38 and c-Jun N-terminal kinase in the B16F10 cells. Moreover, the use of PD98059 (ERK inhibitor) and LY294002 (AKT inhibitor) corroborated these findings, indicating that bergamottin inhibits melanogenesis via the MAPKase and AKT signaling pathway. Thus, bergamottin has potential for treating hyperpigmentation disorders and can be a promising chemical for skin-whitening in the cosmetic industry.

Lipid Peroxidation Activates Mitogen-Activated Protein Kinases in Testicular Ischemia-Reperfusion Injury

2006 ◽  
Vol 176 (4) ◽  
pp. 1666-1672 ◽  
Author(s):  
Pietro Antonuccio ◽  
Letteria Minutoli ◽  
Carmelo Romeo ◽  
Piero Antonio Nicòtina ◽  
Alessandra Bitto ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Reperfusion Injury ◽  
Protein Kinases ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Testicular Ischemia
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