Alkaline phosphatase reduces hepatic and pulmonary injury in liver ischaemia–reperfusion combined with partial resection

2006 ◽  
Vol 93 (4) ◽  
pp. 448-456 ◽  
Author(s):  
S. Q. van Veen ◽  
S. Dinant ◽  
A. K. van Vliet ◽  
T. M. van Gulik
Keyword(s):  
Alkaline Phosphatase ◽  
Partial Resection ◽  
Pulmonary Injury ◽  
Ischaemia Reperfusion ◽  
Liver Ischaemia

THE EFFECT OF 5-AIQ ON THE LIVER ISCHAEMIA/REPERFUSION INJURY

Shock ◽  
2002 ◽  
Vol 18 (Supplement) ◽  
pp. 23
Author(s):  
B. Sepodes ◽  
M. C. McDonald ◽  
R. Pinto ◽  
R. Maio ◽  
M. Caneira-da-Silva ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Liver Ischaemia

Hypertonic saline infusion attenuates pulmonary injury due to ischaemia-reperfusion

2002 ◽  
Vol 171 (S2) ◽  
pp. 23-23
Author(s):  
C. J. Shields ◽  
D. C. Winter ◽  
B. J. Manning ◽  
J. H. Wang ◽  
W. O. Kirwan ◽  
...  
Keyword(s):  
Hypertonic Saline ◽  
Saline Infusion ◽  
Pulmonary Injury ◽  
Ischaemia Reperfusion ◽  
Hypertonic Saline Infusion

scholarly journals The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhihui Jiao ◽  
Yajun Ma ◽  
Qianzhen Zhang ◽  
Yue Wang ◽  
Tao Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Function ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Liver Tissue ◽  
Expression Levels ◽  
Miniature Pigs ◽  
Ischaemia Reperfusion ◽  
Tnf Α ◽  
Liver Ischaemia

Abstract Background Hepatic ischaemia-reperfusion injury (HIRI) is inevitable in complicated liver surgery and is a major factor leading to postoperative complications and liver dysfunction. Studies have shown that the paracrine mechanisms of stem cell may be essential to tissue repair and functional improvement after transplantation. However, the role of the adipose-derived mesenchymal stem cell secretome (ASC-secretome) in liver regeneration in large animals remains to be determined. Methods Twenty-four miniature pigs were subjected to laparoscopic liver ischaemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the ASC group and the ASC-secretome group. Serum and liver tissue samples were collected before the operation and at 1, 3 and 7 days after the operation, and changes in tissue pathology, serum inflammation, liver function, angiogenesis-related factors and liver tissue regeneration-related genes and proteins were evaluated. Results Detailed histological analysis showed that ASCs and the ASC-secretome changed pathological damage to liver tissue after liver ischaemia-reperfusion combined with partial hepatectomy (1 and 3 days: p < 0.01). Compared with the saline and DMEM control groups, the ASC-secretome group had significantly reduced expression levels of ALP (1 and 3 days: p < 0.05), ALT (1 day: p < 0.01; 3 days: p < 0.05) and AST (1 and 3 days: p < 0.01), which promoted the recovery of liver function. Moreover, detection of the expression levels of TNF-α and IL-1β (1 day: p < 0.01; 3 days: p < 0.05), IL-6 (1 and 3 days: p < 0.05) and IL-10 (1 and 3 days: p < 0.01) in serum confirmed that the ASC-secretome had obvious anti-inflammatory effects. In addition, the ASC-secretome increased the expression levels of ANG-1 (3 days: p < 0.01), ANG-2 (3 and 7 days: p < 0.01) and VEGF (1 and 7 days: p < 0.05; 3 days: p < 0.01) and promoted angiogenesis during liver regeneration. Moreover, it promoted the mRNA expression of HGF and Cyclin D1 (1 and 3 days: p < 0.01); increased the levels of p-STAT3 (1 and 3 days: p < 0.01), PCNA and Ki67 (1 and 3 days: p < 0.01; 7 days: p < 0.05); inhibited the negative feedback of SOCS3 (1 and 3 days: p < 0.01); and decreased the mRNA expression of TGF-β (3 days: p < 0.01). The cytokines and growth factors detected in the ASC-secretome included TNF-α, IL-6, IL-1β, ANG-1, ANG-2, VEGF and b-FGF. Conclusion The ASC-secretome alleviates the inflammatory response induced by ischaemia-reperfusion combined with partial hepatectomy in miniature pigs and promotes liver regeneration.

scholarly journals Pre-ischaemic exogenous surfactant reduces pulmonary injury in rat ischaemia/reperfusion

2008 ◽  
Vol 33 (3) ◽  
pp. 625-633 ◽  
Author(s):  
C. Muhlfeld ◽  
I-M. Schaefer ◽  
L. Becker ◽  
C. Bussinger ◽  
M. Vollroth ◽  
...  
Keyword(s):  
Exogenous Surfactant ◽  
Pulmonary Injury ◽  
Ischaemia Reperfusion

scholarly journals The Protective Effect of Zinc Against Liver Ischaemia Reperfusion Injury in a Rat Model of Global Ischaemia

2020 ◽  
Vol 10 (3) ◽  
pp. 228-235 ◽  
Author(s):  
Ernest Cheung ◽  
Mehrdad Nikfarjam ◽  
Louise Jackett ◽  
Damien M. Bolton ◽  
Joseph Ischia ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischaemia Reperfusion Injury ◽  
Global Ischaemia ◽  
Ischaemia Reperfusion ◽  
Liver Ischaemia

Liver Ischaemia-Reperfusion Injury

2020 ◽  
pp. 129-141
Author(s):  
Farid Froghi ◽  
Saied Froghi ◽  
Brian R. Davidson
Keyword(s):  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Liver Ischaemia

Pulmonary injury due to ischaemia-reperfusion is ameliorated by hypertonic saline infusion

2002 ◽  
Vol 171 (S1) ◽  
pp. 44-44
Author(s):  
C. J. Shields ◽  
B. Manning ◽  
D. C. Winter ◽  
J. H. Wang ◽  
W. O. Kirwan ◽  
...  
Keyword(s):  
Hypertonic Saline ◽  
Saline Infusion ◽  
Pulmonary Injury ◽  
Ischaemia Reperfusion ◽  
Hypertonic Saline Infusion
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