Relationship between symptom response and oesophageal acid exposure after medical and surgical treatment for gastro-oesophageal reflux disease

2004 ◽  
Vol 91 (11) ◽  
pp. 1460-1465 ◽  
Author(s):  
A. D. Jenkinson ◽  
S. S. Kadirkamanathan ◽  
S. M. Scott ◽  
E. Yazaki ◽  
D. F. Evans
Keyword(s):  
Surgical Treatment ◽  
Reflux Disease ◽  
Acid Exposure ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease ◽  
Symptom Response

scholarly journals Systematic review: the effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux disease

2009 ◽  
Vol 30 (11-12) ◽  
pp. 1091-1102 ◽  
Author(s):  
N. L. DE GROOT ◽  
J. S. BURGERHART ◽  
P. C. VAN DE MEEBERG ◽  
D. R. DE VRIES ◽  
A. J. P. M. SMOUT ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Treatment ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease ◽  
Conservative And Surgical Treatment

The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro-oesophageal reflux disease

2013 ◽  
Vol 37 (5) ◽  
pp. 555-563 ◽  
Author(s):  
R. Anggiansah ◽  
R. Sweis ◽  
A. Anggiansah ◽  
T. Wong ◽  
D. Cooper ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Acid Exposure ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease

Number of reflux episodes on pH-impedance monitoring associates with improved symptom outcome and treatment satisfaction in gastro-oesophageal reflux disease (GERD) patients with regurgitation

Gut ◽  
2020 ◽  
pp. gutjnl-2020-321395 ◽  
Author(s):  
Benjamin D Rogers ◽  
Luis R Valdovinos ◽  
Michael D Crowell ◽  
Reginald Bell ◽  
Marcelo F Vela ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Symptom Improvement ◽  
Characteristic Analysis ◽  
Hrql Score ◽  
Oesophageal Reflux Disease ◽  
Related Quality ◽  
Symptom Response ◽  
Impedance Monitoring ◽  
Acid Exposure Time

ObjectiveNumber of reflux episodes, an adjunctive metric on pH-impedance monitoring, is incompletely studied. We aimed to determine if number of reflux episodes associates with therapeutic outcome in regurgitation predominant gastro-oesophageal reflux disease (GERD).DesignWe performed post hoc analysis of postintervention pH-impedance data from adult patients with moderate/severe regurgitation despite QD proton pump inhibitor (PPI), randomised to either two times a day PPI or magnetic sphincter augmentation (MSA) in 2:1 allocation. After 6 and 12 months, symptom response was defined by improvement in Foregut Symptom Questionnaire (FSQ) regurgitation score to none or minimal, ≥50% reduction in GERD health-related quality of life (HRQL) score and satisfaction with therapy. Univariate and multivariate analyses were performed to determine predictors of symptom improvement.ResultsOf 152 randomised patients, 123 (age 46.9±1.2 year, 43% female) had complete data. Symptom and satisfaction scores significantly improved after MSA compared with two times a day PPI. Both acid exposure time (13.4%±0.7% to 1.3±0.2%, p<0.001) and reflux episodes (86±4 to 48±4, p<0.001) declined with therapy. Reduction to <40 reflux episodes was significantly more frequent in those with symptom response by FSQ regurgitation score, GERD HRQL score and satisfaction with therapy (p≤0.03 for each); <35 episodes performed better on receiver operating characteristic analysis. On multivariate analysis, improvement in regurgitation score remained independently predictive of satisfaction with therapy (p<0.001 for each). In patients crossing over to MSA, >80 episodes pretreatment predicted improvement.ConclusionsReduction of reflux episodes on pH-impedance to physiological levels associates with improved outcomes, while pathological levels predict improvement with MSA in regurgitation predominant GERD.Trail registration numberClinicalTrials.gov: NCT02505945.

scholarly journals The effects of tegaserod (HTF 919) on oesophageal acid exposure in gastro-oesophageal reflux disease

2000 ◽  
Vol 14 (11) ◽  
pp. 1503-1509 ◽  
Author(s):  
P. J. Kahrilas ◽  
E. M. M. Quigley ◽  
D. O. Castell ◽  
S. J. Spechler
Keyword(s):  
Reflux Disease ◽  
Acid Exposure ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease

Surgical treatment for recurrent gastro-oesophageal reflux disease after failed antireflux surgery

2000 ◽  
Vol 87 (2) ◽  
pp. 243-249 ◽  
Author(s):  
J. E. Bais ◽  
J. M. L. M. Horbach ◽  
A. A. M. Masclee ◽  
A. J. P. M. Smout ◽  
J. L. Terpstra ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Reflux Disease ◽  
Antireflux Surgery ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease
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