Endothelin-1 is a mediator of intimal hyperplasia in organ culture of human saphenous vein

1997 ◽  
Vol 84 (4) ◽  
pp. 499-503 ◽  
Author(s):  
I. Masood ◽  
K. E. Porter ◽  
N. J. M. London
Keyword(s):  
Organ Culture ◽  
Saphenous Vein ◽  
Intimal Hyperplasia ◽  
Human Saphenous Vein ◽  
Endothelin 1

scholarly journals Endothelin-B receptors mediate intimal hyperplasia in an organ culture of human saphenous vein

1998 ◽  
Vol 28 (4) ◽  
pp. 695-701 ◽  
Author(s):  
Karen E. Porter ◽  
Deji H. Olojugba ◽  
Imran Masood ◽  
Mark Pemberton ◽  
Peter R.F. Bell ◽  
...  
Keyword(s):  
Organ Culture ◽  
Saphenous Vein ◽  
Intimal Hyperplasia ◽  
Human Saphenous Vein ◽  
Endothelin B

scholarly journals A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model

2010 ◽  
Vol 52 (6) ◽  
pp. 1596-1607 ◽  
Author(s):  
Luciana B. Lopes ◽  
Colleen M. Brophy ◽  
Charles R. Flynn ◽  
Zhengping Yi ◽  
Benjamin P. Bowen ◽  
...  
Keyword(s):  
Organ Culture ◽  
Saphenous Vein ◽  
Intimal Hyperplasia ◽  
Peptide Inhibitor ◽  
Human Saphenous Vein ◽  
Culture Model

scholarly journals Human saphenous vein organ culture: A useful model of intimal hyperplasia?

1996 ◽  
Vol 11 (1) ◽  
pp. 48-58 ◽  
Author(s):  
Karen E. Porter ◽  
Kevin Varty ◽  
Louise Jones ◽  
Peter R.F. Bell ◽  
Nicholas J.M. London
Keyword(s):  
Organ Culture ◽  
Saphenous Vein ◽  
Intimal Hyperplasia ◽  
Human Saphenous Vein

Nature and origin of the neointima in whole vessel wall organ culture of the human saphenous vein

1996 ◽  
Vol 428 (1) ◽  
pp. 59-67 ◽  
Author(s):  
J. Slomp ◽  
A. C. Gittenberger-de Groot ◽  
J. C. van Munsteren ◽  
R. E. Poelmann ◽  
H. A. Huysmans ◽  
...  
Keyword(s):  
Organ Culture ◽  
Saphenous Vein ◽  
Vessel Wall ◽  
Human Saphenous Vein

Comparison of response to injury in organ culture of human saphenous vein and internal mammary artery

1993 ◽  
Vol 55 (6) ◽  
pp. 1522-1528 ◽  
Author(s):  
Cathy M. Holt ◽  
Sheila E. Francis ◽  
Andrew C. Newby ◽  
Suzanne Rogers ◽  
Patricia A. Gadsdon ◽  
...  
Keyword(s):  
Organ Culture ◽  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Human Saphenous Vein ◽  
Internal Mammary

Abstract 293: Clinical Predictors of Endothelial Function in Human Saphenous Vein

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Michael J Osgood ◽  
Kyle Hocking ◽  
Eric S Wise ◽  
Kevin W Sexton ◽  
Padmini Komalavilas ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Saphenous Vein ◽  
Intimal Hyperplasia ◽  
Vein Graft ◽  
Graft Failure ◽  
Univariate Analysis ◽  
Clinical Predictors ◽  
Human Saphenous Vein ◽  
Graft Harvest ◽  
Vein Graft Failure

BACKGROUND: Human saphenous vein (HSV) remains the most widely utilized conduit for vascular bypass procedures. Outcomes remain limited by vein graft failure and intimal hyperplasia. Endothelial function is considered an important determinant of vein graft failure. We have observed significant variability in endothelial function in freshly isolated HSV samples. We therefore evaluated clinical predictors of endothelial function in HSV. Methods: We obtained freshly isolated HSV samples from the operating room immediately following harvest from patients undergoing coronary artery bypass procedures from Vanderbilt University Hospital and the Nashville VA Hospital. We obtained HSV samples prior to any intraoperative manipulations. HSV viability, smooth muscle function, and endothelial-dependent relaxation (EDR) were measured in a muscle bath. We collected the following clinical and demographic information: age, height, weight, gender, ethnicity, medical comorbidities, laboratory values (creatinine, HbA1c, lipids), ejection fraction, preoperative medication regimen, and method of vein graft harvest. We performed a univariate and multivariate analysis of predictors of endothelial function in HSV. Results: HSV samples were obtained from 149 patients. HSV EDR varied from -11% to 63%. Open harvest was employed for 39 HSV samples, compared with endoscopic harvest in 110 HSV samples. On univariate analysis, only open harvest was a statistically significant predictor of endothelial function (p=0.02): mean HSV EDR was 21.5% in HSV samples harvested open, compared with 15.4% in HSV harvested with an endoscopic technique. HSV EDR was also improved with preoperative aspirin use: mean HSV EDR was 18% in patients with preoperative aspirin use compared with 11.6% in patients who were not administered preoperative aspirin in a multivariate model when controlling for method of vein graft harvest (p=0.05). Conclusions: Endoscopic vein graft harvest is associated with endothelial dysfunction in HSV, while preoperative aspirin use is associated with improved endothelial function. Further work will be necessary to determine whether these factors are associated with development of intimal hyperplasia and vein graft failure.

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