Growth enhancement of implanted human colorectal cancer cells by the addition of fibroblasts in vivo

1996 ◽  
Vol 83 (1) ◽  
pp. 24-28 ◽  
Author(s):  
M. C. Loizidou ◽  
R. Carpenter ◽  
H. Laurie ◽  
A. J. Cooper ◽  
P. Alexander ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Growth Enhancement ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane potentiates in vitro and in vivo antitumor effects of irinotecan on human colorectal cancer cells

2016 ◽  
Vol 11 (5) ◽  
pp. 3551-3557
Author(s):  
PO-SHENG YANG ◽  
JANE-JEN WANG ◽  
YEA-HWEY WANG ◽  
WOAN-CHING JAN ◽  
SHIH-PING CHENG ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Antitumor Effects ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin

2018 ◽  
Vol 49 (5) ◽  
pp. 2035-2046 ◽  
Author(s):  
Zhi Chen ◽  
Ruizhi Hou ◽  
Shuohui Gao ◽  
Defeng Song ◽  
Ye Feng
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
P53 Pathway ◽  
Ezrin Expression ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells ◽  
Hct116 Cells

Background/Aims: The present study was aimed at examining Ezrin expression in human colorectal cancer (CRC) tissues and elucidating the influence of baicalein on the proliferation of HCT116 cells. Methods: The expression of Ezrin was determined by qRT-PCR and immunohistochemistry. HCT116 cells were divided into four groups－ baicalein groups with various concentrations, pcDNA3.1-Ezrin group, si-Ezrin group and dual inhibitory group (baicalein + si-Ezrin). CCK-8 assay and flow cytometry (FCM) were employed to assess cell proliferation and to detect the distribution of cell cycle respectively. The expression levels of Ezrin protein and cell cycle-associated proteins were detected by using western blot. The proliferation ability of CRC cells was also evaluated in vivo. Results: Ezrin expression in CRC tissues was observably higher than that in adjacent colorectal tissues. With drug concentration and action time of baicalein increasing, the cell propagation capacity of HCT116 cells was decreased and the cell cycle progression was arrested. Ezrin expression was inhibited by the administration of baicalein in a dose-dependent way. The levels of CyclinD1 and CDK4 were also significantly decreased, but the expression of P53 pathway proteins P53 and P21 was markedly upregulated. Conclusion: Baicalein repressed proliferation of human colorectal cancer cells HCT116 and blocked cell cycle through downregulating Ezrin and upregulating P53 pathway-related proteins.

In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells

2009 ◽  
Vol 134 (1) ◽  
pp. 2-10 ◽  
Author(s):  
Shinji Sakuma ◽  
Takanori Yano ◽  
Yoshie Masaoka ◽  
Makoto Kataoka ◽  
Ken-ichiro Hiwatari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells
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