Beneficial response to pituitary ablation following aminoglutethimide

1986 ◽  
Vol 73 (5) ◽  
pp. 388-389 ◽  
Author(s):  
N. J. Bundred ◽  
O. Eremin ◽  
Helen J. Stewart ◽  
B. A. Dale ◽  
A. P. M. Forrest
Keyword(s):  
Beneficial Response ◽  
Pituitary Ablation

CUSHING'S SYNDROME FOLLOWING PARTIAL ADRENALECTOMY AND COMPLETE HYPOPHYSECTOMY

1965 ◽  
Vol 48 (4) ◽  
pp. 565-568 ◽  
Author(s):  
W. A. Sullivan ◽  
Jerrold D. Hydovitz ◽  
H. Rosomoff ◽  
T. S. Danowski
Keyword(s):  
Cushing’S Syndrome ◽  
Adult Male ◽  
Successful Treatment ◽  
Cushing's Syndrome ◽  
Partial Adrenalectomy ◽  
The Third ◽  
Subtotal Adrenalectomy ◽  
Pituitary Ablation ◽  
Acth Secreting

ABSTRACT A third episode of Cushing's syndrome developed in an adult male who had undergone subtotal adrenalectomy and then complete hypophysectomy in temporarily successful treatment of two earlier episodes. Judging from necropsy findings, this final recurrence was not the result of incomplete pituitary ablation or regeneration of pituitary remnants. Extrasellar pituitary or other ACTH secreting tissue could not be identified, but the patient's marked melanosis suggested its presence with consequent excesses of ACTH or MSH. However, irrespective of whether such excesses did or did not exist, it is clear that the third episode of Cushing's syndrome resulted from hyperfunction of the small adrenal remnant.

An Unsuccessful Attempt to Treat Hypertension with Acupuncture

1977 ◽  
Vol 05 (01) ◽  
pp. 39-44 ◽  
Author(s):  
K. Sugioka ◽  
W. Mao ◽  
J. Woods ◽  
R. A. Mueller
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Acupuncture Treatment ◽  
Plasma Catecholamines ◽  
Systemic Blood Pressure ◽  
Patient Acceptance ◽  
Unsuccessful Attempt ◽  
Poor Patient ◽  
Beneficial Response

The effectiveness of 5 sets of acupuncture loci in decreasing systemic blood pressure was compared with chlorthalidone and propranolol in patients with essential hypertension. No statistically significant acute or long-term changes in plasma catecholamines, renin activity, or blood pressure and pulse rate were observed as a result of acupuncture treatment. The decrease in blood pressure was significantly less than the observed with propranolol, but not significantly less than produced by chlorthalidone. Because of the poor patient acceptance of acupuncture and in the absence of a beneficial response, we feel acupuncture as employed in this study is of limited value in the management of patients with essential hypertension.

Lactulose in the Management of Constipation: A Current Review

1992 ◽  
Vol 26 (10) ◽  
pp. 1277-1282 ◽  
Author(s):  
Theresa V. Kot ◽  
Ngaire A. Pettit-Young
Keyword(s):  
Clinical Trials ◽  
Adverse Effects ◽  
Clinical Studies ◽  
Data Extraction ◽  
Point Of View ◽  
Data Synthesis ◽  
Study Selection ◽  
Beneficial Response ◽  
A Current

OBJECTIVE: To review the current published clinical studies evaluating the clinical efficacy and safety of lactulose compared with other laxatives or placebo. Adverse effects associated with lactulose are also reported. DATA SOURCES: Information was retrieved by searching the MEDLINE and EMBASE databases for clinical trials, abstracts, conference proceedings, and review articles dealing with lactulose. STUDY SELECTION: Emphasis was placed on clinical trials where lactulose was compared with other laxatives or placebo in patient populations where the diagnosis of constipation was reasonably established. DATA EXTRACTION: The methodology and results from clinical studies were evaluated. Assessment of the studies was made based on diagnosis of constipation, prior management of patients, follow-up of patients, dosage, and adverse effects. DATA SYNTHESIS: Clinical trials in geriatric patients, terminally ill patients, children, and normal and constipated subjects were reviewed. In most instances, lactulose was compared with a placebo, without incorporating the current education on dietary techniques for improving defecation. CONCLUSIONS: Generally, clinical trials have demonstrated a beneficial response compared with placebo, although sometimes that response has been only marginally better, from a clinical point of view.

Physiological significance of behavioral hypothermia in hypoxic toads (Bufo marinus)

1991 ◽  
Vol 159 (1) ◽  
pp. 203-215 ◽  
Author(s):  
S. C. Wood ◽  
G. M. Malvin
Keyword(s):  
Behavioral Response ◽  
Thermal Gradient ◽  
Respiratory Exchange Ratio ◽  
Ventilatory Response ◽  
Respiratory Alkalosis ◽  
Significant Rise ◽  
Bufo Marinus ◽  
Significant Drop ◽  
Preferred Temperature ◽  
Beneficial Response

We tested the hypotheses that hypoxic toads (Bufo marinus) in a thermal gradient would select a lower than normal temperature and that this behavioral response would be beneficial. Under normoxic conditions, selected body temperature was 24.2 +/− 3.6 degrees C. When inspired O2 was 10% or less, mean selected temperature decreased to 15.3 +/− 2.4 degrees C. The theoretical advantages of hypoxia-induced hypothermia we tested include (1) a reduction of oxygen uptake (VO2) by a Q10 effect; (2) increased arterial saturation (SaO2), (3) a decreased ventilatory response, and (4) a decreased stress response. Gas exchange, hematocrit, hemoglobin, SaO2, PaO2 and pH were measured at 25 degrees C (normal preferred temperature) and 15 degrees C (hypoxia preferred temperature) in toads breathing normoxic or hypoxic gas mixtures. During graded hypoxia at 15 degrees C, SaO2 was significantly increased and VO2 was significantly reduced compared with 25 degrees C. Graded hypoxia did not significantly affect VO2 at 25 degrees C, despite evidence for increased ventilation at that temperature (increased pH and respiratory exchange ratio, RE). At 15 degrees C, graded hypoxia had a significant effect on VO2 only at an inspired O2 of 4%. Increased RE with hypoxia was significant at 25 degrees C but not at 15 degrees C. Hematocrit and [hemoglobin] rose significantly during graded hypoxia at 25 degrees C but did not change at 15 degrees C. Toads exposed to 10% O2 (the value that elicits behavioral hypothermia) showed a significant respiratory alkalosis at 25 degrees C but not at 15 degrees C. Likewise, hypoxia caused a significant drop in SaO2 and PO2 at 25 degrees C. Cooling to 15 degrees C during hypoxia caused a significant rise in SaO2 but no change in PaO2. In conclusion, behavioral hypothermia is a beneficial response to hypoxia in Bufo marinus.

The use of feed supplements to reduce livestock greenhouse gas emissions: direct-fed microbials

2021 ◽  
pp. 261-286
Author(s):  
Natasha Doyle ◽  
◽  
Philiswa Mbandlwa ◽  
Sinead Leahy ◽  
Graeme Attwood ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Nitrous Oxide ◽  
Greenhouse Gas Emissions ◽  
Greenhouse Gas ◽  
Large Scale ◽  
Important Variable ◽  
Gas Emissions ◽  
Feed Supplements ◽  
Beneficial Response ◽  
On Farm

This chapter aims to outline the strategy of using feed supplements for the reduction of greenhouse gas emissions (GHG) in ruminants, including methane (CH4), carbon dioxide and nitrous oxide, given that feed intake is an important variable in predicting these emissions. Focus will be given to direct-fed microbials, a term reserved for live microbes which can be supplemented to feed to elicit a beneficial response. The viability of such methods will also be analysed for their use in large scale on-farm operations.

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