Improved immediate function of experimental cadaver renal allografts by elimination of agonal vasospasm

1971 ◽  
Vol 58 (3) ◽  
pp. 184-187 ◽  
Author(s):  
John P. Pryor ◽  
T. Vincent Keaveny ◽  
Thomas W. Reed ◽  
Folkert O. Belzer
Keyword(s):  
Renal Allografts ◽  
Immediate Function

Effect of Use of Vasopressors in Organ Donors on Immediate Function of Renal Allografts

1996 ◽  
Vol 6 (4) ◽  
pp. 215-216
Author(s):  
Elizabeth A O'Brien ◽  
Stephanie A Bour ◽  
Renee L Marshall ◽  
Nasimul Ahsan ◽  
Harold C Yang
Keyword(s):  
Acute Tubular Necrosis ◽  
Renal Allograft ◽  
Organ Donors ◽  
Ischemic Time ◽  
Renal Allografts ◽  
Cold Ischemic Time ◽  
Tubular Necrosis ◽  
Allograft Function ◽  
Immediate Function ◽  
Cadaveric Donors

The purpose of this study was to determine whether use of vasopressors in cadaveric donors of renal transplants was associated with an increased prevalence of acute tubular necrosis after kidney transplantation. We compared immediate allograft function in 26 consecutive renal allograft recipients whose donors had been given vasopressors with that in 26 recipients whose donors had not. The donors treated with vasopressors had been given more than 10 μg/kg per minute of dopamine, norepinephrine, or epinephrine, alone or in combination. The groups were matched with respect to donors' age, recipients' disease, and cold ischemic time. The prevalence of immediate allograft function was significantly lower in recipients whose donors had required use of vasopressors (38.5%) than in recipients whose donors had not required vasopressors (65.4%). We conclude that use of vasopressors in kidney donors leads to an increased prevalence of acute tubular necrosis.

Effect of use of vasopressors in organ donors on immediate function of renal allografts

1996 ◽  
Vol 6 (4) ◽  
pp. 215-216 ◽  
Author(s):  
Elizabeth O'Brien ◽  
Stephanie Bour ◽  
Renee Marshall ◽  
Nasimul Ahsan ◽  
Harold Yang
Keyword(s):  
Organ Donors ◽  
Renal Allografts ◽  
Immediate Function

scholarly journals Glomerular Neovascularization in Nondiabetic Renal Allograft Is Associated with Calcineurin Inhibitor Toxicity

Nephron ◽  
2020 ◽  
pp. 1-6
Author(s):  
Anri Sawada ◽  
Masayoshi Okumi ◽  
Shigeru Horita ◽  
Kohei Unagami ◽  
Sekiko Taneda ◽  
...  
Keyword(s):  
Diabetic Kidney Disease ◽  
Renal Allograft ◽  
Calcineurin Inhibitor ◽  
Clinical Information ◽  
Renal Allografts ◽  
Biopsy Specimens ◽  
Allograft Biopsy ◽  
Time Periods ◽  
Medical University ◽  
Trough Levels

<b><i>Introduction:</i></b> Extra efferent arterioles, also known as polar vasculosis (PV), are often observed in the glomerular vascular pole and are associated with glomerular hypertrophy, indicating early recurrent diabetic kidney disease (DKD) in renal allografts. However, its significance in patients without diabetes remains uncertain. <b><i>Methods:</i></b> A total of 9,004 renal allograft biopsy specimens obtained between January 2007 and December 2017 at Tokyo Women’s Medical University were retrospectively analyzed to examine the clinical and pathological significance of PV in renal allografts. PV was identified in 186 biopsy specimens obtained from 165 patients. The PV group comprised 46 patients; 35 patients without DKD and 11 patients with DKD as the initial cause of ESRD, whose clinical information was available and treated with the calcineurin inhibitor (CNI) tacrolimus. The non-PV group comprising patients with renal allografts matched for age and postoperative day included 93 patients without DKD and 16 patients with DKD as the initial cause of ESRD. <b><i>Results:</i></b> In patients with nondiabetic renal allografts, systolic blood pressure was significantly higher in the PV group than in the non-PV group. The trough tacrolimus levels during the overall study period and at 2 weeks, 1 month, and 2 years after transplantation were significantly higher in the PV group compared with the non-PV group. Glomerulomegaly was significantly more common. Moreover, ah and aah scores in Banff score were significantly higher in the PV group than in the non-PV group. In those with diabetic renal allografts, although the clinical parameters and tacrolimus trough levels in all time periods were not significantly different between the PV and non-PV groups, the ah score was significantly higher in the PV group. <b><i>Conclusion:</i></b> PV was associated with CNI toxicity in nondiabetic but not in diabetic renal allografts. The pathogenesis of PV in renal allografts is considered to be multifactorial.

PRESERVATION OF CADAVER RENAL ALLOGRAFTS: COMPARISON OF ICE STORAGE AND MACHINE PERFUSION

1977 ◽  
Vol 2 (11) ◽  
pp. 353-356 ◽  
Author(s):  
V. C. Marshall ◽  
H. Ross ◽  
D. F. Scott ◽  
S. McInnes ◽  
N. Thomson ◽  
...  
Keyword(s):  
Ice Storage ◽  
Machine Perfusion ◽  
Renal Allografts

EFFECT OF AZATHIOPRINE AND PREDNISOLONE ON PASSIVE ENHANCEMENT OF RAT RENAL ALLOGRAFTS

1978 ◽  
Vol 25 (5) ◽  
pp. 229-234 ◽  
Author(s):  
C. G. WINEARLS ◽  
P. R. MILLARD ◽  
P. J. MORRIS
Keyword(s):  
Renal Allografts
Sign in / Sign up

Export Citation Format

Share Document