scholarly journals Prospective observational cohort study on grading the severity of postoperative complications in global surgery research

2019 ◽  
Vol 106 (2) ◽  
pp. e73-e80 ◽  
Author(s):  
◽  
T. E. F. Abbott ◽  
K. E. Greaves ◽  
A. Patel ◽  
T. Ahmad ◽  
...  
Keyword(s):  
Cohort Study ◽  
Postoperative Complications ◽  
Observational Cohort Study ◽  
Global Surgery ◽  
Prospective Observational Cohort Study ◽  
Surgery Research ◽  
Observational Cohort

scholarly journals Postoperative Complications and Long-Term Quality of Life After Multimodality Treatment for Esophageal Cancer: An Analysis of the Prospective Observational Cohort Study of Esophageal-Gastric Cancer Patients (POCOP)

2021 ◽  
Author(s):  
E. Jezerskyte ◽  
◽  
M. I. van Berge Henegouwen ◽  
H. W. M. van Laarhoven ◽  
J. J. van Kleef ◽  
...  
Keyword(s):  
Cohort Study ◽  
Postoperative Complications ◽  
Anastomotic Leakage ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Significant Difference ◽  
Observational Cohort ◽  
Gastric Cancer Patients

Abstract Background Esophagectomy has major effects on health-related quality of life (HR-QoL). Postoperative complications might contribute to a decreased HR-QOL. This population-based study aimed to investigate the difference in HR-QoL between patients with and without complications after esophagectomy for cancer. Methods A prospective comparative cohort study was performed with data from the Netherlands Cancer Registry (NCR) and Prospective Observational Cohort Study of Esophageal-Gastric Cancer Patients (POCOP). All patients with esophageal and gastroesophageal junction (GEJ) cancer after esophagectomy in the period 2015–2018 were enrolled. The study investigated HR-QoL at baseline, then 3, 6, 9, 12, 18, and 24 months postoperatively, comparing patients with and without complications as well as with and without anastomotic leakage. Results The 486 enrolled patients comprised 270 patients with complications and 216 patients without complications. Significantly more patients with complications had comorbidities (69.6% vs 57.3%; p = 0.001). No significant difference in HR-QoL was found over time between the patients with and without complications. In both groups, a significant decline in short-term HR-QoL was found in various HR-QoL domains, which were restored to the baseline level during the 12-month follow-up period. No significant difference was found in HR-QoL between the patients with and without anastomotic leakage. The patients with grades 2 and 3 anastomotic leakage reported significantly more “choking when swallowing” at 6 months (ß = 14.5; 95% confidence interval [CI], − 24.833 to − 4.202; p = 0.049), 9 months (ß = 22.4, 95% CI, − 34.259 to − 10.591; p = 0.007), and 24 months (ß = 24.6; 95% CI, − 39.494 to − 9.727; p = 0.007) than the patients with grade 1 or no anastomotic leakage. Conclusion In general, postoperative complications were not associated with decreased short- or long-term HR-QoL for patients after esophagectomy for esophageal or GEJ cancer. The temporary decrease in HR-QoL likely is related to the nature of esophagectomy and reconstruction itself.

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