Overall survival before and after centralization of gastric cancer surgery in the Netherlands

2018 ◽  
Vol 105 (13) ◽  
pp. 1807-1815 ◽  
Author(s):  
M. van Putten ◽  
S. D. Nelen ◽  
V. E. P. P. Lemmens ◽  
J. H. M. B. Stoot ◽  
H. H. Hartgrink ◽  
...  
2012 ◽  
Vol 48 (7) ◽  
pp. 1004-1013 ◽  
Author(s):  
Johan L. Dikken ◽  
Anneriet E. Dassen ◽  
Valery E.P. Lemmens ◽  
Hein Putter ◽  
Pieta Krijnen ◽  
...  

2017 ◽  
Vol 28 ◽  
pp. x62-x63
Author(s):  
T. Sato ◽  
T. Aoyama ◽  
Y. Maezawa ◽  
K. Kano ◽  
T. Hayashi ◽  
...  

2016 ◽  
Vol 34 (7_suppl) ◽  
pp. 305-305 ◽  
Author(s):  
Linde A.D. Busweiler ◽  
Johan L. Dikken ◽  
Mark I. van Berge Henegouwen ◽  
Vincent K.Y. Ho ◽  
Daniel Henneman ◽  
...  

305 Background: There is a known volume-outcome association for complex surgial procedures such as oncologic gastric resections. The aim of this study was to describe the process of centralization for gastric cancer surgery in the Netherlands in relation to other types of upper gastrointestinal (GI) cancer resections and to investigate whether the quality of gastric cancer surgery is affected by the overall experience with those related complex surgical procedures. Methods: Data on all patients (n = 4251) who underwent surgical treatment for non metastatic invasive gastric cancer between 2005-2013 were obtained from the Netherlands Cancer Registry. Annual hospital volume categories were based on the overall volume of gastrectomies, esophagectomies and pancreatectomies together (composite hospital volume). Volume-outcome analyses were performed for lymph node yield, 30-day mortality, and overall survival. Results: The percentage of gastric cancer patients who underwent a resection in a hospital with a volume of at least 20 gastrectomies per year increased. At the same time, the percentage of gastric cancer patients who underwent surgery in hospitals with an annual composite hospital volume of at least 20 upper GI cancer resections, such as esophageal and pancreatic cancer resections, increased. A higher composite hospital volume was associated with a higher lymph node yield, a lower 30-day mortality, and an increased overall survival. Conclusions: In the Netherlands, an increasing proportion of gastric cancer resections is performed in hospitals that are high volume centers for esophagectomies and pancreatectomies for cancer. Experience with these complex surgical procedures has a favorable effect on the outcomes of gastric cancer surgery.


2021 ◽  
Author(s):  
Xuhui Zhuang ◽  
Yuewen He ◽  
Wuhua Ma

Abstract Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been proven to improve the survival rate of gastric cancer and reduce peritoneal recurrence. We aimed to evaluate the effectiveness and safety of prophylactic HIPEC after radical gastric cancer surgery in this study.Methods: Researchers searched for studies published in PubMed, Embase, Web of science, Scopus, Cochrane, Clinicalkey databases and Microsoft Academic databases to identify studies that examine the impact of prophylactic HIPEC on the survival, recurrence and adverse events of patients undergoing radical gastric cancer surgery. RevMan 5.3 was used to analyze the results and risk of bias. The PROSERO registration number is CRD42021262016.Results: This meta-analysis included 19 studies with a total of 2097 patients, 12 of which are RCTs. The results showed that the 1-,3-and 5-year overall survival rate was significantly favorable to HIPEC (OR=5.10,2.47,1.96 respectively). Compared with the control group, the overall recurrence rate and peritoneal recurrence rate of the HIPEC group were significantly lower (OR=0.43,0.26 respectively). Significantly favorable to the control group in terms of renal dysfunction and pulmonary dysfunction complications(OR=2.44,6.03 respectively). Regarding the causes of death due to postoperative recurrence: liver recurrence, lymph node and local recurrence and peritoneal recurrence, the overall effect is not significantly different (OR=0.81,1.19,0.37 respectively).Conclusions: 1-,3-and 5-year overall survival follow-up can be incremented by the prophylactic HIPEC, and which can significantly reduce the overall recurrence rate and peritoneal recurrence rate. HIPEC can cause significant pulmonary dysfunction and renal dysfunction complications. No difference has been found in the deaths due to recurrence after surgery.


2016 ◽  
Vol 42 (9) ◽  
pp. S116 ◽  
Author(s):  
L. Heuthorst ◽  
S.D. Nelen ◽  
R.H.A. Verhoeven ◽  
F. Polat ◽  
M. Kruyt ◽  
...  

Author(s):  
Lisa C. Murnane ◽  
Adrienne K. Forsyth ◽  
Jim Koukounaras ◽  
Charles HC. Pilgrim ◽  
Kalai Shaw ◽  
...  

2020 ◽  
Vol 4 (4) ◽  
pp. 360-368 ◽  
Author(s):  
Takeshi Kubota ◽  
Katsutoshi Shoda ◽  
Hirotaka Konishi ◽  
Kazuma Okamoto ◽  
Eigo Otsuji

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