scholarly journals Preliminary results of a cohort study of induction chemotherapy-based treatment for locally recurrent rectal cancer

2017 ◽  
Vol 105 (4) ◽  
pp. 447-452 ◽  
Author(s):  
D. M. G. I. van Zoggel ◽  
S. J. Bosman ◽  
M. Kusters ◽  
G. A. P. Nieuwenhuijzen ◽  
J. S. Cnossen ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cohort Study ◽  
Induction Chemotherapy ◽  
Recurrent Rectal Cancer ◽  
Preliminary Results ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

scholarly journals Improved Outcomes for Responders After Treatment with Induction Chemotherapy and Chemo(re)irradiation for Locally Recurrent Rectal Cancer

2020 ◽  
Vol 27 (9) ◽  
pp. 3503-3513 ◽  
Author(s):  
E. L. K. Voogt ◽  
D. M. G. I. van Zoggel ◽  
M. Kusters ◽  
G. A. P. Nieuwenhuijzen ◽  
J. G. Bloemen ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Induction Chemotherapy ◽  
Recurrent Rectal Cancer ◽  
Locally Recurrent Rectal Cancer ◽  
Improved Outcomes ◽  
Locally Recurrent

scholarly journals Intraoperative Electron Radiation Therapy (IOERT) in the management of locally recurrent rectal cancer

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Falk Roeder ◽  
Joerg-Michael Goetz ◽  
Gregor Habl ◽  
Marc Bischof ◽  
Robert Krempien ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Recurrent Rectal Cancer ◽  
Electron Radiation ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

Usefulness of carcinoembryonic antigen doubling time in prognosis prediction after curative resection of locally recurrent rectal cancer: A retrospective study

2021 ◽  
Author(s):  
JUNICHI SAKAMOTO ◽  
Heita Ozawa ◽  
Hiroki Nakanishi ◽  
Shin Fujita
Keyword(s):  
Rectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Curative Resection ◽  
Doubling Time ◽  
Multivariate Analyses ◽  
Recurrent Rectal Cancer ◽  
Oncologic Outcomes ◽  
Prognosis Prediction ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

Introduction: Given that doubling time is an indicator of tumor growth, we assessed the usefulness of carcinoembryonic antigen doubling time (CEA-DT) in prognosis prediction after curative resection for locally recurrent rectal cancer. Methods: During January 1986 to December 2016, 33 patients with locally recurrent rectal cancer who underwent curative resection at our hospital were retrospectively reviewed. The primary endpoint was the 3-year recurrence-free survival (RFS) rate. The Kaplan-Meier method was used to compare RFS rates and evaluate univariate and multivariate analyses for factors associated with oncologic outcomes, including CEA-DT. CEA-DT was classified into two groups: the short and long CEA-DT groups. Results: The 3-year overall survival and RFS rates were 62.6% and 42.4%, respectively. In multivariate analyses, CEA-DT was an independent risk factor for poor RFS. The 3-year RFS rate was significantly better in the long CEA-DT group than in the short CEA-DT group (58.8% vs. 25.0%, p = 0.0063). Conclusion: CEA-DT is a useful prognostic factor that can be assessed before surgery for locally recurrent rectal cancer. Long CEA-DT may indicate a favorable prognosis. Contrarily, short CEA-DT is associated with poor prognosis; therefore, further treatment intervention is necessary for patients with short CEA-DT.

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