Semi‐rational engineering of an aldo‐keto reductase Km AKR for overcoming trade‐offs between catalytic activity and thermostability

2021 ◽  
Author(s):  
Shu‐Fang Li ◽  
Jian‐Yong Xie ◽  
Shuai Qiu, ◽  
Shen‐Yuan Xu ◽  
Feng Cheng ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Rational Engineering ◽  
Trade Offs

Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate

2018 ◽  
Vol 8 (18) ◽  
pp. 4718-4725 ◽  
Author(s):  
Jiang-Wei Shen ◽  
Jia-Mei Qi ◽  
Xiao-Jian Zhang ◽  
Zhi-Qiang Liu ◽  
Yu-Guo Zheng
Keyword(s):  
Catalytic Activity ◽  
Binding Pocket ◽  
Candida Antarctica ◽  
Candida Antarctica Lipase B ◽  
Candida Antarctica Lipase ◽  
Lipase B ◽  
Rational Engineering ◽  
Engineering Approach

Structure-based semi-rational engineering approach was applied to alter the binding pocket and substrate channel for enhancing the activity of CALB towards moxifloxacin chiral intermediate.

(Invited) Promising Methods for Overcoming Trade-Offs Among Catalytic Activity, Durability, and Power Density By Controlling Pt/Ionomer Interfaces

2020 ◽  
Vol MA2020-02 (36) ◽  
pp. 2317-2317
Author(s):  
Kensaku Kodama ◽  
Haruhiko Yamada ◽  
Shuhei Yoshino ◽  
Kenji Kudo ◽  
Takahisa Suzuki ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Power Density ◽  
Trade Offs

Engineering of a fungal nitrilase for improving catalytic activity and reducing by-product formation in the absence of structural information

2016 ◽  
Vol 6 (12) ◽  
pp. 4134-4141 ◽  
Author(s):  
Jin-Song Gong ◽  
Heng Li ◽  
Zhen-Ming Lu ◽  
Xiao-Juan Zhang ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Structural Information ◽  
Product Formation ◽  
Rational Engineering ◽  
Engineering Approach

Semi-rational engineering approach was employed to improve the catalytic activity and reduce the by-product formation of fungal nitrilase.

High resolution electron microscopy of lanthanum phosphate crystals

1978 ◽  
Vol 36 (1) ◽  
pp. 274-275
Author(s):  
J. C. Wheatley ◽  
J. M. Cowley
Keyword(s):  
Electron Microscopy ◽  
Catalytic Activity ◽  
High Resolution ◽  
Petroleum Industry ◽  
High Resolution Electron Microscopy ◽  
Lanthanum Phosphate ◽  
Good Catalyst ◽  
Resolution Electron ◽  
Good Catalytic Activity ◽  
Physical And Chemical

Rare-earth phosphates are of particular interest because of their catalytic properties associated with the hydrolysis of many aromatic chlorides in the petroleum industry. Lanthanum phosphates (LaPO4) which have been doped with small amounts of copper have shown increased catalytic activity (1). However the physical and chemical characteristics of the samples leading to good catalytic activity are not known.Many catalysts are amorphous and thus do not easily lend themselves to methods of investigation which would include electron microscopy. However, the LaPO4, crystals are quite suitable samples for high resolution techniques.The samples used were obtained from William L. Kehl of Gulf Research and Development Company. The electron microscopy was carried out on a JEOL JEM-100B which had been modified for high resolution microscopy (2). Standard high resolution techniques were employed. Three different sample types were observed: 669A-1-5-7 (poor catalyst), H-L-2 (good catalyst) and 27-011 (good catalyst).

The design and catalytic performance of molybdenum active sites on an MCM-41 framework for the aerobic oxidation of 5-hydroxymethylfurfural to 2,5-diformylfuran

2019 ◽  
Vol 9 (3) ◽  
pp. 811-821 ◽  
Author(s):  
Zhao-Meng Wang ◽  
Li-Juan Liu ◽  
Bo Xiang ◽  
Yue Wang ◽  
Ya-Jing Lyu ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Active Sites ◽  
Aerobic Oxidation ◽  
Catalytic Performance ◽  
Mcm 41

The catalytic activity decreases as –(SiO)3Mo(OH)(O) > –(SiO)2Mo(O)2 > –(O)4–MoO.

Novel players fine-tune plant trade-offs

2015 ◽  
Vol 58 ◽  
pp. 83-100 ◽  
Author(s):  
Selena Gimenez-Ibanez ◽  
Marta Boter ◽  
Roberto Solano
Keyword(s):  
Ubiquitin Ligase ◽  
Feedback Loop ◽  
Molecular Level ◽  
26S Proteasome ◽  
Signalling Molecules ◽  
Transcriptional Reprogramming ◽  
Trade Offs ◽  
Jaz Proteins ◽  
Regulatory Feedback Loop ◽  
Fine Tune

Jasmonates (JAs) are essential signalling molecules that co-ordinate the plant response to biotic and abiotic challenges, as well as co-ordinating several developmental processes. Huge progress has been made over the last decade in understanding the components and mechanisms that govern JA perception and signalling. The bioactive form of the hormone, (+)-7-iso-jasmonyl-l-isoleucine (JA-Ile), is perceived by the COI1–JAZ co-receptor complex. JASMONATE ZIM DOMAIN (JAZ) proteins also act as direct repressors of transcriptional activators such as MYC2. In the emerging picture of JA-Ile perception and signalling, COI1 operates as an E3 ubiquitin ligase that upon binding of JA-Ile targets JAZ repressors for degradation by the 26S proteasome, thereby derepressing transcription factors such as MYC2, which in turn activate JA-Ile-dependent transcriptional reprogramming. It is noteworthy that MYCs and different spliced variants of the JAZ proteins are involved in a negative regulatory feedback loop, which suggests a model that rapidly turns the transcriptional JA-Ile responses on and off and thereby avoids a detrimental overactivation of the pathway. This chapter highlights the most recent advances in our understanding of JA-Ile signalling, focusing on the latest repertoire of new targets of JAZ proteins to control different sets of JA-Ile-mediated responses, novel mechanisms of negative regulation of JA-Ile signalling, and hormonal cross-talk at the molecular level that ultimately determines plant adaptability and survival.

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