Eggshell membrane as a bioactive agent in polymeric nanotopographic scaffolds for enhanced bone regeneration

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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Placenta mesenchymal stem cells on a chorion scaffold as a potential osteogenic graft for peripartal bone regeneration

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0028-1088660 ◽

2008 ◽

Vol 68 (S 01) ◽

Author(s):

S Mohr ◽

BC Portmann-Lanz ◽

A Schoeberlein ◽

R Sager ◽

DV Surbek

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Bone Regeneration

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Decision letter for "Macrophage GIT1 contributes to bone regeneration by regulating inflammatory responses in an ERK / NRF2 ‐dependent way"

10.1002/jbmr.4099/v2/decision1 ◽

2020 ◽

Keyword(s):

Bone Regeneration ◽

Inflammatory Responses

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Review for "Macrophage GIT1 contributes to bone regeneration by regulating inflammatory responses in an ERK / NRF2 ‐dependent way"

10.1002/jbmr.4099/v1/review1 ◽

2020 ◽

Keyword(s):

Bone Regeneration ◽

Inflammatory Responses

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Combination of novel two-photon photopolymerised scaffolds and bioactive elastin-like-recombinamers induce bone regeneration

Bone Abstracts ◽

10.1530/boneabs.5.p73 ◽

2016 ◽

Author(s):

Carina Kampleitner ◽

Gerhard Hildebrand ◽

Klaus Liefeith ◽

Constancio Gonzalez ◽

Jose Carlos Rodriguez-Cabello ◽

...

Keyword(s):

Bone Regeneration ◽

Two Photon

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SauFRa technique for the fixation of resorbable membranes in horizontal guided bone regeneration - a technical report

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00265 ◽

2020 ◽

Author(s):

Saurabh Mohan Kamat ◽

Rakshit Khandeparker ◽

Francis Akkara ◽

Vikas Dhupar ◽

Ashwin Mysore

Keyword(s):

Bone Regeneration ◽

Guided Bone Regeneration ◽

Novel Technique ◽

Technical Report ◽

Suturing Techniques ◽

Graft Migration

Membrane fixation in guided bone regeneration (GBR) has been traditionally achieved using resorbable pins, titanium tacks or miniscrews. However, these techniques are marredwith a number of clinical challenges. This article presents the “SauFRa” technique, a novel technique for stabilization of resorbable membranes in both, single as well as multiple implant sites while avoiding the shortcomings of other suturing techniques described in literature. Furthermore, the technique also eliminates the possibility of complications observed when using resorbable pins, titanium tacks or miniscrews, such as damage to adjacent roots during insertion. The authors’ employed this technique in 89 patients (51 male and 35 female) and found no complications like tissue dehiscence, infection or graft migration.

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