Metabolic engineering of Pichia pastoris for malic acid production from methanol

2020 ◽  
Vol 118 (1) ◽  
pp. 357-371
Author(s):  
Feng Guo ◽  
Zhongxue Dai ◽  
Wenfang Peng ◽  
Shangjie Zhang ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Pichia Pastoris ◽  
Malic Acid ◽  
Acid Production

scholarly journals Metabolic engineering of Ustilago trichophora TZ1 for improved malic acid production

2017 ◽  
Vol 4 ◽  
pp. 12-21 ◽  
Author(s):  
Thiemo Zambanini ◽  
Hamed Hosseinpour Tehrani ◽  
Elena Geiser ◽  
Christiane K. Sonntag ◽  
Joerg M. Buescher ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Malic Acid ◽  
Acid Production

Metabolic engineering of Pichia pastoris for L-lactic acid production using glycerin as carbon source

2015 ◽  
Author(s):  
Nadia Skorupa Parachin ◽  
Pollyne Lima ◽  
Nadielle Melo ◽  
Lucas Carvalho ◽  
Virgililio Castro ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Metabolic Engineering ◽  
Pichia Pastoris ◽  
Carbon Source ◽  
Acid Production ◽  
Lactic Acid Production

scholarly journals Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Wei ◽  
Yongxue Xu ◽  
Qing Xu ◽  
Wei Cao ◽  
He Huang ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Malic Acid ◽  
Acid Production ◽  
Large Scale ◽  
Rapid Development ◽  
Tca Cycle ◽  
Dominant Mode ◽  
Comprehensive Overview ◽  
Recent Developments ◽  
Microbial Biosynthesis

Malic acid, a four-carbon dicarboxylic acid, is widely used in the food, chemical and medical industries. As an intermediate of the TCA cycle, malic acid is one of the most promising building block chemicals that can be produced from renewable sources. To date, chemical synthesis or enzymatic conversion of petrochemical feedstocks are still the dominant mode for malic acid production. However, with increasing concerns surrounding environmental issues in recent years, microbial fermentation for the production of L-malic acid was extensively explored as an eco-friendly production process. The rapid development of genetic engineering has resulted in some promising strains suitable for large-scale bio-based production of malic acid. This review offers a comprehensive overview of the most recent developments, including a spectrum of wild-type, mutant, laboratory-evolved and metabolically engineered microorganisms for malic acid production. The technological progress in the fermentative production of malic acid is presented. Metabolic engineering strategies for malic acid production in various microorganisms are particularly reviewed. Biosynthetic pathways, transport of malic acid, elimination of byproducts and enhancement of metabolic fluxes are discussed and compared as strategies for improving malic acid production, thus providing insights into the current state of malic acid production, as well as further research directions for more efficient and economical microbial malic acid production.

Metabolic engineering of Escherichia coli for the production of malic acid

2008 ◽  
Vol 40 (2) ◽  
pp. 312-320 ◽  
Author(s):  
Soo Yun Moon ◽  
Soon Ho Hong ◽  
Tae Yong Kim ◽  
Sang Yup Lee
Keyword(s):  
Escherichia Coli ◽  
Metabolic Engineering ◽  
Malic Acid

Fungal biotransformation of crude glycerol into malic acid

2015 ◽  
Vol 70 (5-6) ◽  
pp. 165-167 ◽  
Author(s):  
Thomas P. West
Keyword(s):  
Organic Acid ◽  
Biomass Production ◽  
Malic Acid ◽  
Acid Production ◽  
Fungal Biomass ◽  
Acid Level ◽  
Crude Glycerol

Abstract Malic acid production from the biodiesel coproduct crude glycerol by Aspergillus niger ATCC 9142, ATCC 10577 and ATCC 12846 was observed to occur with the highest malic acid level acid being produced by A. niger ATCC 12846. Fungal biomass production from crude glycerol was similar, but ATCC 10577 produced the highest biomass. Fungal biotransformation of crude glycerol into the commercially valuable organic acid malic acid appeared feasible.

Characteristics of the high malic acid production mechanism in Saccharomyces cerevisiae sake yeast strain No. 28

2012 ◽  
Vol 114 (3) ◽  
pp. 281-285 ◽  
Author(s):  
Shunichi Nakayama ◽  
Ken Tabata ◽  
Takahiro Oba ◽  
Kenichi Kusumoto ◽  
Shinji Mitsuiki ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Malic Acid ◽  
Yeast Strain ◽  
Acid Production ◽  
Production Mechanism

Metabolic engineering for ricinoleic acid production in the oleaginous yeast Yarrowia lipolytica

2013 ◽  
Vol 98 (1) ◽  
pp. 251-262 ◽  
Author(s):  
A. Beopoulos ◽  
J. Verbeke ◽  
F. Bordes ◽  
M. Guicherd ◽  
M. Bressy ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Ricinoleic Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Oleaginous Yeast ◽  
Yeast Yarrowia Lipolytica
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