scholarly journals Modeling and simulation‐based design of electroenzymatic batch processes catalyzed by unspecific peroxygenase from A. aegerita

2020 ◽  
Vol 118 (1) ◽  
pp. 7-16
Author(s):  
Sebastian Bormann ◽  
Dominik Hertweck ◽  
Sabrina Schneider ◽  
Jonathan Z. Bloh ◽  
Roland Ulber ◽  
...  
Keyword(s):  
Modeling And Simulation ◽  
Batch Processes ◽  
Simulation Based Design ◽  
Simulation Based

Modeling and Simulation Methods for Design of Engineering Systems

2000 ◽  
Vol 1 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Rajarishi Sinha ◽  
Christiaan J. J. Paredis ◽  
Vei-Chung Liang ◽  
Pradeep K. Khosla
Keyword(s):  
Modeling And Simulation ◽  
Design Process ◽  
State Of The Art ◽  
Simulation Software ◽  
Modeling Languages ◽  
Simulation Methods ◽  
Design Tools ◽  
Engineering Systems ◽  
Simulation Based Design ◽  
Simulation Based

This article presents an overview of the state-of-the art in modeling and simulation, and studies to which extent current simulation technologies can effectively support the design process. For simulation-based design, modeling languages and simulation environments must take into account the special characteristics of the design process. For instance, languages should allow models to be easily updated and extended to accommodate the various analyses performed throughout the design process. Furthermore, the simulation software should be well integrated with the design tools so that designers and analysts with expertise in different domains can effectively collaborate on the design of complex artifacts. This review focuses in particular on modeling for design of multi-disciplinary engineering systems that combine continuous time and discrete time phenomena.

scholarly journals Investigating Preconditions for Sustainable Renewable Energy Product–Service Systems in Retail Electricity Markets

Energies ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 1877
Author(s):  
Widha Kusumaningdyah ◽  
Tetsuo Tezuka ◽  
Benjamin C. McLellan
Keyword(s):  
Renewable Energy ◽  
Electricity Markets ◽  
Service Systems ◽  
Energy Market ◽  
Energy Product ◽  
Simulation Based Design ◽  
Product Service ◽  
Simulation Based ◽  
Sustainable Renewable Energy ◽  
Product Service Systems

Energy transitions are complex and involve interrelated changes in the socio-technical dimensions of society. One major barrier to renewable energy transitions is lock-in from the incumbent socio-technical regime. This study evaluates Energy Product–Service Systems (EPSS) as a renewable energy market mechanism. EPSS offer electricity service performance instead of energy products and appliances for household consumers. Through consumers buying the service, the provider company is enabled to choose, manage and control electrical appliances for best-matched service delivery. Given the heterogenous market players and future uncertainties, this study aims to identify the necessary conditions to achieve a sustainable renewable energy market. Simulation-Based Design for EPSS framework is implemented to assess various hypothetical market conditions’ impact on market efficiency in the short term and long term. The results reveal the specific market characteristics that have a higher chance of causing unexpected results. Ultimately, this paper demonstrates the advantage of implementing Simulation-Based Design for EPSS to design retail electricity markets for renewable energy under competing market mechanisms with heterogenous economic agents.

scholarly journals Optimal Scheduling for Laboratory Automation of Life Science Experiments with Time Constraints

2021 ◽  
pp. 247263032110217
Author(s):  
Takeshi D. Itoh ◽  
Takaaki Horinouchi ◽  
Hiroki Uchida ◽  
Koichi Takahashi ◽  
Haruka Ozaki
Keyword(s):  
Scheduling Algorithms ◽  
Mixed Integer ◽  
Time Constraints ◽  
Live Cells ◽  
Laboratory Automation ◽  
Simulation Based Design ◽  
Simulation Based ◽  
Optimal Allocations ◽  
Scheduling Method ◽  
Time Required

In automated laboratories consisting of multiple different types of instruments, scheduling algorithms are useful for determining the optimal allocations of instruments to minimize the time required to complete experimental procedures. However, previous studies on scheduling algorithms for laboratory automation have not emphasized the time constraints by mutual boundaries (TCMBs) among operations, which is important in procedures involving live cells or unstable biomolecules. Here, we define the “scheduling for laboratory automation in biology” (S-LAB) problem as a scheduling problem for automated laboratories in which operations with TCMBs are performed by multiple different instruments. We formulate an S-LAB problem as a mixed-integer programming (MIP) problem and propose a scheduling method using the branch-and-bound algorithm. Simulations show that our method can find the optimal schedules of S-LAB problems that minimize overall execution time while satisfying the TCMBs. Furthermore, we propose the use of our scheduling method for the simulation-based design of job definitions and laboratory configurations.

Energy-saving design of variable-displacement bi-directional pump-controlled electrohydraulic system

2020 ◽  
pp. 095965182097389
Author(s):  
Samir Kumar Hati ◽  
Nimai Pada Mandal ◽  
Dipankar Sanyal
Keyword(s):  
Energy Saving ◽  
Absolute Error ◽  
Fast Response ◽  
Maximum Energy ◽  
Radial Clearance ◽  
Simulation Based Design ◽  
Simulation Based ◽  
Displacement Pump ◽  
Variable Displacement ◽  
Axial Piston

Losses in control valves drag down the average overall efficiency of electrohydraulic systems to only about 22% from nearly 75% for standard pump-motor sets. For achieving higher energy efficiency in slower systems, direct pump control replacing fast-response valve control is being put in place through variable-speed motors. Despite the promise of a quicker response, displacement control of pumps has seen slower progress for exhibiting undesired oscillation with respect to the demand in some situations. Hence, a mechatronic simulation-based design is taken up here for a variable-displacement pump–controlled system directly feeding a double-acting single-rod cylinder. The most significant innovation centers on designing an axial-piston pump with an electrohydraulic compensator for bi-directional swashing. An accumulator is conceived to handle the flow difference in the two sides across the load piston. A solenoid-driven sequence valve with P control is proposed for charging the accumulator along with setting its initial gas pressure by a feedforward design. Simple proportional–integral–derivative control of the compensator valve is considered in this exploratory study. Appropriate setting of the gains and critical sizing of the compensator has been obtained through a detailed parametric study aiming low integral absolute error. A notable finding of the simulation is the achievement of the concurrent minimum integral absolute error of 3.8 mm s and the maximum energy saving of 516 kJ with respect to a fixed-displacement pump. This is predicted for the combination of the circumferential port width of 2 mm for the compensator valve and the radial clearance of 40 µm between each compensator cylinder and the paired piston.

CPI Stress Induced Carrier Mobility Shift in Advanced Silicon Nodes

2016 ◽  
Author(s):  
Valeriy Sukharev ◽  
Jun-Ho Choy ◽  
Armen Kteyan ◽  
Henrik Hovsepyan ◽  
Uwe Muehle ◽  
...  
Keyword(s):  
Electrical Characterization ◽  
Compact Modeling ◽  
Electrical Characteristics ◽  
Mobility Shift ◽  
Physical Strain ◽  
Multi Scale ◽  
Modeling Methodology ◽  
Simulation Based Design ◽  
Simulation Based ◽  
Final Design

Potential challenges with managing mechanical stress and the consequent effects on device performance for advanced 3D IC technologies are outlined. The growing need for a simulation-based design verification flow capable of analyzing and detecting across-die out-of-spec stress-induced variations in MOSFET/FinFET electrical characteristics is highlighted. A physics-based compact modeling methodology for multi-scale simulation of all contributing components of stress induced variability is described. A simulation flow that provides an interface between layout formats (GDS II, OASIS), and FEA-based package-scale tools, is also developed. This tool, can be used to optimize the floorplan for different circuits and packaging technologies, and/or for the final design signoff, for all stress induced phenomena. Finally, a calibration technique based on fitting to measured electrical characterization data is presented, along with correlation of the electrical characteristics to direct physical strain measurements.

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