scholarly journals Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

2020 ◽  
Vol 117 (4) ◽  
pp. 1101-1116 ◽  
Author(s):  
Audrey Berger ◽  
Valérie Le Fourn ◽  
Jacqueline Masternak ◽  
Alexandre Regamey ◽  
Iris Bodenmann ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chinese Hamster Ovary ◽  
Protein Production ◽  
Target Genes ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Ovary Cells

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

2020 ◽  
Vol 17 ◽  
Author(s):  
Shazid Md. Sharker ◽  
Md. Atiqur Rahman
Keyword(s):  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Mass Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Specific Productivity ◽  
Ovary Cells ◽  
Further Development ◽  
Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies

2017 ◽  
Vol 33 (6) ◽  
pp. 1449-1455 ◽  
Author(s):  
Zhilan Hu ◽  
Wendy Hsu ◽  
Abby Pynn ◽  
Domingos Ng ◽  
Donna Quicho ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Protein Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells

Enhancing Protein Production Yield from Chinese Hamster Ovary Cells by CRISPR Interference

2017 ◽  
Vol 6 (8) ◽  
pp. 1509-1519 ◽  
Author(s):  
Chih-Che Shen ◽  
Li-Yu Sung ◽  
Shih-Yeh Lin ◽  
Mei-Wei Lin ◽  
Yu-Chen Hu
Keyword(s):  
Chinese Hamster Ovary ◽  
Protein Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Production Yield ◽  
Ovary Cells ◽  
Crispr Interference
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