Coexpression of CMP‐sialic acid transporter reduces N ‐glycolylneuraminic acid levels of recombinant glycoproteins in Chinese hamster ovary cells

2019 ◽  
Vol 116 (11) ◽  
pp. 2815-2822 ◽  
Author(s):  
Dong Gyun Kang ◽  
Chang Sup Kim ◽  
Hyung Joon Cha
Keyword(s):  
Sialic Acid ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Recombinant Glycoproteins ◽  
Acid Transporter

Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins

10.1038/15104 ◽  
1999 ◽  
Vol 17 (11) ◽  
pp. 1116-1121 ◽  
Author(s):  
S. Weikert ◽  
D. Papac ◽  
J. Briggs ◽  
D. Cowfer ◽  
S. Tom ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Chinese Hamster Ovary ◽  
Acid Content ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Sialic Acid Content ◽  
Ovary Cells ◽  
Recombinant Glycoproteins

scholarly journals Detection of mSiglec-E, in solution and expressed on the surface of Chinese hamster ovary cells, using sialic acid functionalised gold nanoparticles

The Analyst ◽  
2016 ◽  
Vol 141 (20) ◽  
pp. 5799-5809 ◽  
Author(s):  
Claire L. Schofield ◽  
María J. Marín ◽  
Martin Rejzek ◽  
Paul R. Crocker ◽  
Robert A. Field ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Sialic Acid ◽  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Specific Detection ◽  
Ovary Cells

Glyconanoparticles have been synthesised for the specific detection of mSiglec-E in solution and expressed on the surface of CHO cells.

Malignancy-related characteristics of wild type and drug-resistant chinese hamster ovary cells

Pathology ◽  
1993 ◽  
Vol 25 (3) ◽  
pp. 268-276 ◽  
Author(s):  
Wanda B. Mackinnon ◽  
Marlen Dyne ◽  
Rebecca Hancock ◽  
Carolyn E. Mountford ◽  
Adrienne J. Grant ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Drug Resistant ◽  
Wild Type ◽  
Ovary Cells

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

2020 ◽  
Vol 17 ◽  
Author(s):  
Shazid Md. Sharker ◽  
Md. Atiqur Rahman
Keyword(s):  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Mass Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Specific Productivity ◽  
Ovary Cells ◽  
Further Development ◽  
Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

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