scholarly journals Raw materials evaluation and process development studies for conversion of biomass to sugars and ethanol

1981 ◽  
Vol 23 (1) ◽  
pp. 163-183 ◽  
Author(s):  
C. R. Wilke ◽  
R. D. Yang ◽  
A. F. Sciamanna ◽  
R. P. Freitas
Keyword(s):  
Process Development ◽  
Raw Materials ◽  
Development Studies

scholarly journals Multiple-Monitor HPLC Assays for Rapid Process Development, In-Process Monitoring, and Validation of AAV Production and Purification

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 113
Author(s):  
Pete Gagnon ◽  
Blaz Goricar ◽  
Nina Mencin ◽  
Timotej Zvanut ◽  
Sebastijan Peljhan ◽  
...  
Keyword(s):  
Light Scattering ◽  
Process Monitoring ◽  
Process Development ◽  
Raw Materials ◽  
Intrinsic Fluorescence ◽  
Size Exclusion ◽  
Adeno Associated Virus ◽  
Complex Samples ◽  
Exclusion Chromatography ◽  
Peak Areas

HPLC is established as a fast convenient analytical technology for characterizing the content of empty and full capsids in purified samples containing adeno-associated virus (AAV). UV-based monitoring unfortunately over-estimates the proportion of full capsids and offers little value for characterizing unpurified samples. The present study combines dual-wavelength UV monitoring with intrinsic fluorescence, extrinsic fluorescence, and light-scattering to extend the utility of HPLC for supporting development of therapeutic AAV-based drugs. Applications with anion exchange (AEC), cation exchange (CEC), and size exclusion chromatography (SEC) are presented. Intrinsic fluorescence increases sensitivity of AAV detection over UV and enables more objective estimation of empty and full capsid ratios by comparison of their respective peak areas. Light scattering enables identification of AAV capsids in complex samples, plus semiquantitative estimation of empty and full capsid ratios from relative peak areas of empty and full capsids. Extrinsic Picogreen fluorescence enables semiquantitative tracking of DNA with all HPLC methods at all stages of purification. It does not detect encapsidated DNA but reveals DNA associated principally with the exteriors of empty capsids. It also enables monitoring of host DNA contamination across chromatograms. These enhancements support many opportunities to improve characterization of raw materials and process intermediates, to accelerate process development, provide rapid in-process monitoring, and support process validation.

Trends in Precision Manufacturing Based on Intelligent Design and Advanced Metrology

2013 ◽  
Vol 581 ◽  
pp. 417-422 ◽  
Author(s):  
M. Numan Durakbasa ◽  
Gokcen Bas ◽  
Jorge Martin Bauer ◽  
Günther Poszvek
Keyword(s):  
Environmental Sustainability ◽  
Manufacturing Systems ◽  
Process Development ◽  
Raw Materials ◽  
Cost Effective ◽  
Intelligent Manufacturing ◽  
Production Engineering ◽  
Comprehensive Knowledge ◽  
Product And Process ◽  
The One

ts of extreme importance in present time of worldwide international competition in industry and production engineering to safe time on the one hand and on the other keep an eye on increasingly higher costs of energy and raw materials. Comprehensive knowledge in the areas of market requirements, product and process development and design, intelligent metrology and end of life management are important presuppositions to achieve rapid, agile, waste free and cost-effective production of innovative, customized complex products using next-generation materials as well as to protect the environment by making zero emissions and improve environmental sustainability and reduce the use of energy by using intelligent manufacturing systems.

Process development studies for recovery of bio active isolates from spent black pepper generated from ayurvedic industry

2015 ◽  
Vol 66 ◽  
pp. 144-149 ◽  
Author(s):  
Gurpur Rakesh D. Prabhu ◽  
Challa Ravi Kiran ◽  
A. Sundaresan ◽  
Rajesh S. Mony ◽  
V.V. Venugopalan
Keyword(s):  
Process Development ◽  
Black Pepper ◽  
Development Studies

Biological production of functional chemicals from renewable resources

2008 ◽  
Vol 86 (6) ◽  
pp. 548-555 ◽  
Author(s):  
Yutaka Tokiwa ◽  
Buenaventurada P Calabia
Keyword(s):  
Lactic Acid ◽  
Succinic Acid ◽  
Renewable Resources ◽  
Process Development ◽  
Raw Materials ◽  
Hydroxybutyric Acid ◽  
Butylene Succinate ◽  
Major Shift ◽  
Pharmaceutical Industries ◽  
Biological Methods

The development and implementation of renewable feedstocks for the production of multifunctional chemicals has received attention from the food and pharmaceutical industries and also as potential raw materials for the manufacture of biodegradable polymers. A major shift towards renewable resources, however, requires new ways to optimize and evaluate industrial processes. There are several possibilities to replace chemical techniques with biological methods based on renewable resources. This review discusses some examples of process development in which a biotechnological route might be favorable leading to industrial realization. Herein are described the production of biomaterials that can be used as monomers in plastics, such as lactic acid for polylactide (PLA), (R)-3-hydroxybutyric acid (R-3HB) for poly[(R)-3-hydroxybutyrate] (PHB), and succinic acid for poly(butylene succinate) (PBS). Moreover, several species of microorganisms that produce significant quantities of these functional chemicals under specific cultivation conditions from biomass-derived carbohydrates are also reviewed.Key words: functional chemicals, renewable resources, lactic acid, (R)-3-hydroxybutyric acid, succinic acid.

Engineering Solutions in Scale-Up and Tank Design for Metal Hydrides

2018 ◽  
Vol 941 ◽  
pp. 2220-2225
Author(s):  
Giovanni Capurso ◽  
Julian Jepsen ◽  
José M. Bellosta von Colbe ◽  
Claudio Pistidda ◽  
Oliver Metz ◽  
...  
Keyword(s):  
Hydrogen Storage ◽  
Process Development ◽  
Raw Materials ◽  
Storage System ◽  
Scale Up ◽  
Holistic Approach ◽  
Hydrogen Storage Materials ◽  
Hydrogen Storage System ◽  
Tank Design ◽  
Cost Efficient

A holistic approach is required for the development of materials and systems for hydrogen storage, embracing all the different steps involved in a successful advance of the technology. The several engineering solutions presented in this work try to address the technical challenges in synthesis and application of solid-state hydrogen storage materials, mainly metal hydride based compounds. Moving from the synthesis of samples in lab-scale to the production of industrial sized batches a novel process development is required, including safety approaches (for hazardous powders), and methods to prevent the contamination of sensitive chemicals. The reduction of overall costs has to be addressed as well, considering new sources for raw materials and more cost-efficient catalysts. The properties of the material itself influence the performances of the hydride in a pilot storage tank, but the characteristics of the system itself are crucial to investigate the reaction limiting steps and overcome hindrances. For this, critical experiments using test tanks are needed, learning how to avoid issues as material segregation or temperature gradients, and optimizing the design in the aspects of geometry, hull material, and test station facilities. The following step is a useful integration of the hydrogen storage system into real applications, with other components like fuel cells or hydrogen generators: these challenging scenarios provide insights to design new experiments and allow stimulating demonstrations.

scholarly journals BIORECOVER - New Bio-based Technologies for Recapture of Critical Raw Materials

2020 ◽  
Author(s):  
Annette Alcasabas ◽  
Felicity Massingberd-Mundy ◽  
Barbara Breeze ◽  
Maite Ruiz Pérez ◽  
Cristina Martínez García
Keyword(s):  
High Selectivity ◽  
Process Development ◽  
Raw Materials ◽  
Selective Extraction ◽  
End Users ◽  
Primary Sources ◽  
Quality Requirements ◽  
Three Stages ◽  
Downstream Processes ◽  
Critical Raw Materials

BIORECOVER brings together diverse expertise with the goal of developing a new sustainable and safe process, essentially based on biotechnology, for selective extraction of Critical Raw Materials (CRMs) rare earth elements, magnesium, and PGM. The four-year EU H2020 project involves fourteen international partners from mining, microbiology, chemistry, engineering, metallurgy, sustainable process development, as well as CRM end-users. Starting from relevant unexploited secondary and primary sources of CRMs, BIORECOVER will develop and integrate three stages for CRM extraction – (1) Removal of major impurities present in raw materials and (2) Mobilisation of CRMs through use of microorganisms and (3) Development of specific technologies for recovering metals with high selectivity and purity that meet the quality requirements for reuse. Downstream processes will be developed and recovered metals will be assessed by end-users. Modelling and integration of the modular stages and economic and environmental assessment will be done to develop the most effective and sustainable process.

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