Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

2016 ◽  
Vol 113 (11) ◽  
pp. 2416-2424 ◽  
Author(s):  
Thomas E. Matthews ◽  
Brandon N. Berry ◽  
John Smelko ◽  
Justin Moretto ◽  
Brandon Moore ◽  
...  
Keyword(s):  
Cell Culture ◽  
Raman Spectroscopy ◽  
Cell Density ◽  
Mammalian Cell ◽  
Protein Production ◽  
Closed Loop ◽  
Mammalian Cell Culture ◽  
Lactate Concentration ◽  
Closed Loop Control ◽  
Loop Control

Comparison of Fluidized Bed and Ultrasonic Cell-Retention Systems for High Cell Density Mammalian Cell Culture

2003 ◽  
Vol 19 (3) ◽  
pp. 1045-1048 ◽  
Author(s):  
M.P. Durrschmid ◽  
K. Landauer ◽  
G. Simic ◽  
H. Klug ◽  
T. Keijzer ◽  
...  
Keyword(s):  
Cell Culture ◽  
Fluidized Bed ◽  
Cell Density ◽  
Mammalian Cell ◽  
High Cell Density ◽  
Mammalian Cell Culture ◽  
High Cell ◽  
Cell Retention

Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

2015 ◽  
Vol 32 (1) ◽  
pp. 224-234 ◽  
Author(s):  
Brandon N. Berry ◽  
Terrence M. Dobrowsky ◽  
Rebecca C. Timson ◽  
Rashmi Kshirsagar ◽  
Thomas Ryll ◽  
...  
Keyword(s):  
Cell Culture ◽  
Raman Spectroscopy ◽  
Product Quality ◽  
Mammalian Cell ◽  
Glucose Control ◽  
Mammalian Cell Culture ◽  
Protein Product

Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy

2018 ◽  
Vol 34 (6) ◽  
pp. 1574-1580 ◽  
Author(s):  
Thomas E. Matthews ◽  
John P. Smelko ◽  
Brandon Berry ◽  
Saly Romero‐Torres ◽  
Dan Hill ◽  
...  
Keyword(s):  
Cell Culture ◽  
Raman Spectroscopy ◽  
Mammalian Cell ◽  
Near Infrared ◽  
Mammalian Cell Culture ◽  
Glucose Monitoring

Raman spectroscopy as a method to replace off‐line pH during mammalian cell culture processes

2019 ◽  
Vol 117 (1) ◽  
pp. 146-156 ◽  
Author(s):  
Carl Rafferty ◽  
Jim O'Mahony ◽  
Barbara Burgoyne ◽  
Rosemary Rea ◽  
Karin M. Balss ◽  
...  
Keyword(s):  
Cell Culture ◽  
Raman Spectroscopy ◽  
Mammalian Cell ◽  
Mammalian Cell Culture
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