Host cell proteins in biotechnology-derived products: A risk assessment framework

2015 ◽  
Vol 112 (11) ◽  
pp. 2284-2291 ◽  
Author(s):  
Christina L. Zuch de Zafra ◽  
Valerie Quarmby ◽  
Kathleen Francissen ◽  
Martin Vanderlaan ◽  
Judith Zhu-Shimoni
Keyword(s):  
Risk Assessment ◽  
Host Cell ◽  
Assessment Framework ◽  
Host Cell Proteins

scholarly journals Host cell proteins in biologics development: Identification, quantitation and risk assessment

2009 ◽  
Vol 103 (3) ◽  
pp. 446-458 ◽  
Author(s):  
Xing Wang ◽  
Alan K. Hunter ◽  
Ned M. Mozier
Keyword(s):  
Risk Assessment ◽  
Host Cell ◽  
Host Cell Proteins

scholarly journals Precision analysis for the determination of steric mass action parameters using eight tobacco host cell proteins

2021 ◽  
pp. 462379
Author(s):  
C.R. Bernau ◽  
R.C. Jäpel ◽  
J.W. Hübbers ◽  
S. Nölting ◽  
P. Opdensteinen ◽  
...  
Keyword(s):  
Host Cell ◽  
Mass Action ◽  
Precision Analysis ◽  
Host Cell Proteins

scholarly journals Risk Assessment Framework to Avoid Serial Failure for New Technical Solutions Applied to the Construction of a CLT Structure Resilient to Climate

Buildings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 247
Author(s):  
Charlotte Svensson Tengberg ◽  
Carl-Eric Hagentoft
Keyword(s):  
Risk Assessment ◽  
Success Factors ◽  
Real Life ◽  
Qualitative Assessment ◽  
Technical Solution ◽  
Functional Requirements ◽  
Assessment Framework ◽  
Construction Period ◽  
Design Build ◽  
Technical Solutions

Design-build contractors are challenged with the task of minimizing failure risks when introducing new technical solutions or adapting technical solutions to new conditions, e.g., climate change. They seem to have a disproportional trust in suppliers and their reference cases and might not have adequate resources or methodologies for sufficient evaluation. This creates the potential for serial failures to spread in the construction industry. To mitigate this, it was suggested that a predefined risk assessment framework should be introduced with the aim of providing a prequalification and requirements for the use of the technical solution. The objectives of this paper are to develop a comprehensive risk assessment framework and to explore the framework’s potential to adequately support the design-build contractor’s decisions. The framework uses qualitative assessment, relying on expert workshops and quantitative assessments, with a focus on simulation and probabilities. Tollgates are used to communicate risk assessments to the contractor. The framework is applied to a real-life case study of construction with a CLT-structure for a Swedish design-build contractor, where exposure to precipitation during construction is a key issue. In conclusion, the chosen framework was successful in a design-build contractor context, structuring the process and identifying difficulties in achieving the functional requirements concerning moisture. Three success factors were: documentation and communication, expert involvement, and the use of tollgates. Recommendations to the design-build contractor on construction of CLT structure are to keep construction period short and to use full weather protection on site.

A Hybrid Fuzzy Risk Assessment Framework for Determining Building Demolition Safety Index

2021 ◽  
Vol 25 (4) ◽  
pp. 1144-1162
Author(s):  
Milad Alipour-Bashary ◽  
Mehdi Ravanshadnia ◽  
Hamidreza Abbasianjahromi ◽  
Ehsan Asnaashari
Keyword(s):  
Risk Assessment ◽  
Assessment Framework ◽  
Safety Index ◽  
Fuzzy Risk Assessment ◽  
Building Demolition
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