Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models

2014 ◽  
Vol 112 (1) ◽  
pp. 84-97 ◽  
Author(s):  
Lia Tescione ◽  
James Lambropoulos ◽  
Madhava Ram Paranandi ◽  
Helena Makagiansar ◽  
Thomas Ryll
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Design Principles ◽  
Bioreactor Design ◽  
Scale Down

Development of a scale down cell culture model using multivariate analysis as a qualification tool

2013 ◽  
Vol 30 (1) ◽  
pp. 152-160 ◽  
Author(s):  
Valerie Liu Tsang ◽  
Angela X. Wang ◽  
Helena Yusuf-Makagiansar ◽  
Thomas Ryll
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Cell Culture Model ◽  
Culture Model ◽  
Scale Down

Development and Qualification of a Cell Culture Scale‐Down Model

2019 ◽  
pp. 391-405
Author(s):  
Sarwat Khattak ◽  
Valerie Pferdeort
Keyword(s):  
Cell Culture ◽  
Scale Down ◽  
A Cell

Application of Multivariate Analysis toward Biotech Processes: Case Study of a Cell-Culture Unit Operation

2007 ◽  
Vol 23 (1) ◽  
pp. 61-67 ◽  
Author(s):  
A.O. Kirdar ◽  
J.S. Conner ◽  
J. Baclaski ◽  
A.S. Rathore
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Unit Operation ◽  
A Cell

Bioreactor environment-sensitive sentinel genes as novel metrics for cell culture scale-down comparability

2012 ◽  
Vol 28 (5) ◽  
pp. 1138-1151 ◽  
Author(s):  
Bhargavi Kondragunta ◽  
Bharat H. Joshi ◽  
Jing Han ◽  
Kurt A. Brorson ◽  
Raj K. Puri ◽  
...  
Keyword(s):  
Cell Culture ◽  
Scale Down

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

2014 ◽  
Vol 31 (2) ◽  
pp. 566-577 ◽  
Author(s):  
Brandon Berry ◽  
Justin Moretto ◽  
Thomas Matthews ◽  
John Smelko ◽  
Kelly Wiltberger
Keyword(s):  
Cell Culture ◽  
Raman Spectroscopy ◽  
Multivariate Analysis ◽  
Predictive Modeling ◽  
Cho Cell ◽  
Cho Cell Culture ◽  
Culture Growth ◽  
Cell Culture Growth

scholarly journals Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

2013 ◽  
Vol 91 (11) ◽  
pp. 2265-2274 ◽  
Author(s):  
Alvin W. Nienow ◽  
William H. Scott ◽  
Christopher J. Hewitt ◽  
Colin R. Thomas ◽  
Gareth Lewis ◽  
...  
Keyword(s):  
Cell Culture ◽  
Product Quality ◽  
Animal Cell ◽  
Animal Cell Culture ◽  
Scale Down ◽  
The Impact ◽  
Stress Parameters
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