Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies

Edward J. Close; Jeffrey R. Salm; Timothy Iskra; Eva Sørensen; Daniel G. Bracewell

doi:10.1002/bit.24898

Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies

Biotechnology and Bioengineering ◽

10.1002/bit.24898 ◽

2013 ◽

Vol 110 (9) ◽

pp. 2425-2435 ◽

Cited By ~ 14

Author(s):

Edward J. Close ◽

Jeffrey R. Salm ◽

Timothy Iskra ◽

Eva Sørensen ◽

Daniel G. Bracewell

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Kinetic Studies ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Process Visualization

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Author response for "The prevention of an anomalous chromatographic behavior and the resulting successful removal of viruses from monoclonal antibody with an asymmetric charge distribution by using a membrane adsorber in highly efficient, anion‐exchange chromatography in flow‐through mode"

10.1002/btpr.2955/v2/response1 ◽

2019 ◽

Author(s):

Yumiko Masuda ◽

Yuka Ogino ◽

Kozo Yamaichi ◽

Yusuke Takahashi ◽

Koichi Nonaka ◽

...

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Charge Distribution ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Author Response ◽

Chromatographic Behavior ◽

Successful Removal ◽

Flow Through ◽

Membrane Adsorber

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Decision letter for "The prevention of an anomalous chromatographic behavior and the resulting successful removal of viruses from monoclonal antibody with an asymmetric charge distribution by using a membrane adsorber in highly efficient, anion‐exchange chromatography in flow‐through mode"

10.1002/btpr.2955/v2/decision1 ◽

2019 ◽

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Charge Distribution ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Chromatographic Behavior ◽

Highly Efficient ◽

Successful Removal ◽

Flow Through ◽

Membrane Adsorber

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Characterization of Recombinant Monoclonal Antibody Charge Variants Using OFFGEL Fractionation, Weak Anion Exchange Chromatography, and Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.5b01452 ◽

2015 ◽

Vol 87 (12) ◽

pp. 6204-6211 ◽

Cited By ~ 28

Author(s):

Alyssa Neill ◽

Christine Nowak ◽

Rekha Patel ◽

Gomathinayagam Ponniah ◽

Nidia Gonzalez ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Anion Exchange ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Recombinant Monoclonal Antibody ◽

Charge Variants ◽

Weak Anion Exchange Chromatography

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Monoclonal antibody purification by medium-performance anion-exchange chromatography

Trends in Genetics ◽

10.1016/0168-9525(87)90189-2 ◽

1987 ◽

Vol 3 ◽

pp. 89

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Antibody Purification

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Decision letter for "The prevention of an anomalous chromatographic behavior and the resulting successful removal of viruses from monoclonal antibody with an asymmetric charge distribution by using a membrane adsorber in highly efficient, anion‐exchange chromatography in flow‐through mode"

10.1002/btpr.2955/v1/decision1 ◽

2019 ◽

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Charge Distribution ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Chromatographic Behavior ◽

Highly Efficient ◽

Successful Removal ◽

Flow Through ◽

Membrane Adsorber

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Advance chromatin extraction improves the performance of electropositive mixed-mode chromatography as a capture step and enables its integration with void-exclusion anion exchange chromatography as a two-column-step purification platform for monoclonal antibody production

Biochemical Engineering Journal ◽

10.1016/j.bej.2018.11.018 ◽

2019 ◽

Vol 142 ◽

pp. 145-152 ◽

Cited By ~ 2

Author(s):

Wenshuai Liu ◽

Yue Sun ◽

Jianli Yu ◽

Quan Chen ◽

Zixian Bao ◽

...

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Antibody Production ◽

Mixed Mode ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Monoclonal Antibody Production

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A simple and efficient purification platform for monoclonal antibody production based on chromatin-directed cell culture clarification integrated with precipitation and void-exclusion anion exchange chromatography

Journal of Biotechnology ◽

10.1016/j.jbiotec.2016.08.014 ◽

2016 ◽

Vol 236 ◽

pp. 128-140 ◽

Cited By ~ 8

Author(s):

Quan Chen ◽

Sarah Maria Abdul Latiff ◽

Phyllicia Toh ◽

Xinying Peng ◽

Aina Hoi ◽

...

Keyword(s):

Cell Culture ◽

Monoclonal Antibody ◽

Anion Exchange ◽

Antibody Production ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Monoclonal Antibody Production

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Review for "The prevention of an anomalous chromatographic behavior and the resulting successful removal of viruses from monoclonal antibody with an asymmetric charge distribution by using a membrane adsorber in highly efficient, anion‐exchange chromatography in flow‐through mode"

10.1002/btpr.2955/v2/review1 ◽

2019 ◽

Author(s):

Toshihiko Kadoya

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Charge Distribution ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Chromatographic Behavior ◽

Highly Efficient ◽

Successful Removal ◽

Flow Through ◽

Membrane Adsorber

Download Full-text

Review for "The prevention of an anomalous chromatographic behavior and the resulting successful removal of viruses from monoclonal antibody with an asymmetric charge distribution by using a membrane adsorber in highly efficient, anion‐exchange chromatography in flow‐through mode"

10.1002/btpr.2955/v1/review2 ◽

2019 ◽

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Charge Distribution ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Chromatographic Behavior ◽

Highly Efficient ◽

Successful Removal ◽

Flow Through ◽

Membrane Adsorber

Download Full-text

A seamless and nonprotein A‐based monoclonal antibody purification platform using void‐exclusion anion exchange chromatography and electropositive multimodal chromatography enhanced by advance chromatin extraction

Journal of Chemical Technology & Biotechnology ◽

10.1002/jctb.6146 ◽

2019 ◽

Vol 94 (10) ◽

pp. 3344-3355

Author(s):

Wenshuai Liu ◽

Quan Chen ◽

Xiying Fan ◽

Yunlong Liang ◽

Yue Sun ◽

...

Keyword(s):

Monoclonal Antibody ◽

Anion Exchange ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Antibody Purification ◽

Multimodal Chromatography

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