Perfusion flow rate substantially contributes to the performance of the HepaRG-AMC-bioartificial liver

2012 ◽  
Vol 109 (12) ◽  
pp. 3182-3188 ◽  
Author(s):  
Geert A.A. Nibourg ◽  
Justin D. Boer ◽  
Tessa V. van der Hoeven ◽  
Mariëtte T. Ackermans ◽  
Thomas M. van Gulik ◽  
...  
Keyword(s):  
Flow Rate ◽  
Bioartificial Liver ◽  
Perfusion Flow ◽  
Perfusion Flow Rate

Effect of arginine depletion on glomerular and tubular kidney function: studies in isolated perfused rat kidneys

1991 ◽  
Vol 261 (5) ◽  
pp. F779-F786 ◽  
Author(s):  
J. Radermacher ◽  
B. Klanke ◽  
S. Kastner ◽  
G. Haake ◽  
H. J. Schurek ◽  
...  
Keyword(s):  
Flow Rate ◽  
Specific Inhibitor ◽  
Free Water ◽  
Renal Perfusion ◽  
Physiological Concentration ◽  
Perfusion Flow ◽  
Glucose Reabsorption ◽  
Glomerular Hemodynamics ◽  
Perfusion Flow Rate ◽  
Rat Kidneys

The effect of L-Arg depletion on glomerular hemodynamics and tubular function of isolated rat kidneys perfused with a medium containing 21 amino acids has been studied. A cyclooxygenase inhibitor was added throughout for blockade of prostaglandin synthesis. Arg depletion caused significant (approximately 30%) reductions in renal perfusion flow rate (PFR, 13.9 +/- 1.2 vs. 19.8 +/- 0.6 ml.min-1.g (kidney wt-1), glomerular filtration rate (GFR, 598 +/- 79 vs. 924 +/- 42 microliters.min-1.g kidney wt-1), and urine flow rate (139 +/- 38 vs. 192 +/- 13 microliters.min-1.g kidney wt-1) compared with control kidneys, which were perfused with a physiological concentration of Arg (200 microM). Filtration fraction (FF) increased with Arg depletion (5.1 +/- 0.4 vs. 4.4 +/- 0.4%). Arg-depleted kidneys had a lower absolute sodium (TNa, 75.7 +/- 8.8 vs. 107.9 +/- 6.0 mumol.min-1.g kidney wt-1) and glucose reabsorption (T glucose, 3.7 +/- 0.6 vs. 5.6 +/- 0.5 mumol.min-1.g kidney wt-1), corresponding to a lower sodium and glucose filtration. Potassium handling and reabsorption of free water were not changed. Oxygen consumption (QO2) was lower in Arg-depleted kidneys (4.6 +/- 0.3 vs. 5.5 +/- 0.5 mumol.min-1.g kidney wt-1). The effects of Arg depletion were completely reversed by the addition of Arg (1 mM) at 120 min and partly reversed by the addition of citrulline (1 mM). Ornithine depletion or addition had no effect on PFR, GFR, FF, TNa, T glucose, and QO2. N omega-methyl-L-arginine, a specific inhibitor of nitric oxide endothelium-derived relaxing factor, produced the same effect as Arg depletion.(ABSTRACT TRUNCATED AT 250 WORDS)

Indocyanine green R15 ratio depends directly on liver perfusion flow rate

2009 ◽  
Vol 17 (2) ◽  
pp. 180-185 ◽  
Author(s):  
Martin W. W. Janssen ◽  
Karl T. Druckrey-Fiskaaen ◽  
Leyla Omidi ◽  
Grzegorz Sliwinski ◽  
Christine Thiele ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Flow Rate ◽  
Liver Perfusion ◽  
Perfusion Flow ◽  
Perfusion Flow Rate

Contributions of Liver Perfusion Flow Rate and Enzyme Inhibition to Altered Verapamil Clearance With Halothane

1990 ◽  
Vol 71 (5) ◽  
pp. 484???488 ◽  
Author(s):  
Edward J. Frink ◽  
Thomas H. Kramer ◽  
Susan M. Banchy ◽  
Burnell R. Brown
Keyword(s):  
Enzyme Inhibition ◽  
Flow Rate ◽  
Liver Perfusion ◽  
Perfusion Flow ◽  
Perfusion Flow Rate

scholarly journals Optimal Continuous Retrograde Coronary Perfusion Flow Rate with Beating Heart in Normal Temperature

2004 ◽  
Vol 28 (3) ◽  
pp. 303-309 ◽  
Author(s):  
Toshihide Tsukioka ◽  
Sigeyuki Tomita ◽  
Go Watanabe ◽  
Hirohumi Takemura
Keyword(s):  
Flow Rate ◽  
Beating Heart ◽  
Coronary Perfusion ◽  
Perfusion Flow ◽  
Perfusion Flow Rate

scholarly journals Reciprocal functional interactions between the respiration/circulation center, the upper spinal cord, and the trigeminal system

2015 ◽  
Vol 6 (1) ◽  
pp. 87-102 ◽  
Author(s):  
Itaru Yazawa ◽  
Seiji Shioda
Keyword(s):  
Spinal Cord ◽  
Flow Rate ◽  
Feedback Mechanism ◽  
Sympathetic Tone ◽  
Trigeminal System ◽  
Functional Interaction ◽  
Total Blood ◽  
Perfusion Flow ◽  
Discharge Patterns ◽  
Perfusion Flow Rate

AbstractThe interplay of neural discharge patterns involved in “respiration”, “circulation”, “opening movements in the mandible”, and “locomotion” was investigated electrophysiologically in a decerebrate and arterially perfused in situ rat preparation. Sympathetic tone increased with increases in perfusion flow rate. All nerve discharges became clearly organized into discharge episodes of increasing frequency and duration punctuated by quiescent periods as the perfusion flow rate increased at 26ºC. The modulated sympathetic tone at 10× total blood volume/ min activated the forelimb pattern generator and spontaneously generated fictive forelimb movement during discharge episodes. The coupling rhythm of respiration and locomotion during motion occurred at frequency ratios ranges of 1:2 and 1:3. Small increases in systemic pressure were always generated after the initiation of motion. Opening movements in the mandible, occurring during the inspiratory phase at all tested flow rates, were generated in both the inspiratory and expiratory phases during motion. Although the central mechanism for the entrainment of respiratory and locomotor rhythms has not been identified, a spinal-feedback mechanism generating fictive locomotion in the upper spinal cord contributed to generating the opening movement in the mandible in the expiratory phase during motion. The existence of this mechanism implies that there is a reciprocal functional interaction between the brainstem and the spinal cord, whereby the intake and output of air by the lungs is efficiently improved during movement by both nasal and mouth breathing. These results suggest that this reciprocal functional interaction plays an important role in increasing oxygenated blood flow during locomotion.

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