Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

2010 ◽  
Vol 108 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Rui M. Tostões ◽  
Sofia B. Leite ◽  
Joana P. Miranda ◽  
Marcos Sousa ◽  
Daniel I.C. Wang ◽  
...  
Keyword(s):  
Synergistic Effect

p-Nitrophenylphosphatase Activity Catalyzed by Plasma Membrane (Ca2++Mg2+)ATPase: Correlation with Structural Changes Modulated by Glycerol and Ca2+

2001 ◽  
Vol 21 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Gutemberg G. Alves ◽  
Luis Maurício T. R. Lima ◽  
Maely P. Fávero-Retto ◽  
Adriana P. Lemos ◽  
Carlos E. Peres-Sampaio ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Synergistic Effect ◽  
Phosphatase Activity ◽  
Structural Changes ◽  
Center Of Mass ◽  
Binding Domain ◽  
Dependent Manner ◽  
Dose Dependent ◽  
Substrate Binding Domain

The plasma membrane (Ca2++Mg2+)ATPase hydrolyzes pseudo-substrates such as p-nitrophenylphosphate. Except when calmodulin is present, Ca2+ ions inhibit the p-nitrophenylphosphatase activity. In this report it is shown that, in the presence of glycerol, Ca2+ strongly stimulates phosphatase activity in a dose-dependent manner. The glycerol- and Ca2+-induced increase in activity is correlated with modifications in the spectral center of mass (average emission wavenumber) of the intrinsic fluorescence of the enzyme. It is concluded that the synergistic effect of glycerol and Ca2+ is related to opposite long-term hydration effects on the substrate binding domain and the Ca2+ binding domain.

Spontaneous conception following GnRHa and progestogen therapy in adenomyosis

2016 ◽  
Vol 27 (2) ◽  
Author(s):  
Rima Anggrena Dasrilsyah ◽  
Lim Pei Shan ◽  
Ng Beng Kwang ◽  
Mohamad Nasir Shafiee ◽  
Mohd Hashim Omar
Keyword(s):  
Side Effects ◽  
Synergistic Effect ◽  
Urinary Retention ◽  
Pregnancy Outcome ◽  
Treatment Option ◽  
Luteal Support ◽  
Surgical Risk ◽  
Spontaneous Conception

AbstractAdenomyosis is a common gynaecological disorder that is associated with infertility and miscarriage. We report a case of adenomyosis presented with urinary retention and infertility. The patient successfully conceived spontaneously following GnRHa followed by progestogen therapy. This treatment option might provide a synergistic effect in improving fertility and pregnancy outcome for women with adenomyosis. This modality has no potential surgical risk; it minimises the long-term side effects of GnRHa and also provides luteal support.

Synergistic effect of fluorination and regio-regularity on the long-term thermal stability of polymer solar cells

2016 ◽  
Vol 4 (47) ◽  
pp. 18598-18606 ◽  
Author(s):  
Zidong Li ◽  
Tong Zhang ◽  
Yue Xin ◽  
Xiaoli Zhao ◽  
Dalei Yang ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Solar Cells ◽  
Synergistic Effect ◽  
Polymer Solar Cells ◽  
First Time ◽  
Thermal Stability Of

The synergistic effect of fluorination and regio-regularity is proposed for the first time to realize the long-term thermal stability of polymer solar cells.

Bupivacaine and Glucocorticoid-Induced Myonecrosis

2018 ◽  
Author(s):  
David Gordon ◽  
Ahmad Khattab ◽  
Magdalena Anitescu
Keyword(s):  
Chronic Pain ◽  
Synergistic Effect ◽  
Young Patients ◽  
Repeated Administration ◽  
Tissue Reaction ◽  
Time Dependent ◽  
Muscle Breakdown ◽  
The Common ◽  
Altered Metabolism

The most frequently used medications for chronic pain are local anesthetics (LA) and glucocorticoids. Common adverse events from LA, such as seizures and cardiotoxicity, are well known. A lesser known side effect is local tissue reaction to the LA concentration. Myotoxicity is one of the common denominators of direct tissue reaction to LA; it results from the disruption of the mitochondria in the muscle cells. All LA produce some degree of myotoxicity; bupivacaine has the greatest effect and procaine the least. If LA is combined with glucocorticoid, muscle breakdown is even more extensive showing a synergistic effect. Myotoxicity depends primarily on LA concentration, is time dependent, and is enhanced by preexisting altered metabolism. It affects mostly young patients. Potential effects of long-term or repeated administration of the combination LA/glucocorticoids medications should always be considered and discussed with patients.

The Synergistic Effect of Short and Long Term Exposure to PM2.5 and Temperature on Hospital Admissions in New England

2018 ◽  
Vol 2017 (1) ◽  
pp. 423 ◽  
Author(s):  
Maayan Yitshak-Sade ◽  
Jennifer F. Bobb ◽  
Joel Schwartz ◽  
Itai Kloog ◽  
Antonella Zanobetti
Keyword(s):  
Synergistic Effect ◽  
New England ◽  
Hospital Admissions ◽  
Short And Long Term

scholarly journals Age Matching of Elderly Liver Grafts With Elderly Recipients Does Not Have a Synergistic Effect on Long-term Outcomes When Both Are Carefully Selected

2019 ◽  
Vol 5 (4) ◽  
pp. e342 ◽  
Author(s):  
Nicholas Gilbo ◽  
Ina Jochmans ◽  
Mauricio Sainz-Barriga ◽  
Frederik Nevens ◽  
Schalk van der Merwe ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Long Term Outcomes ◽  
Elderly Recipients

scholarly journals Long-Term Effect of Combination of Creatine Monohydrate Plus β-Hydroxy β-Methylbutyrate (HMB) on Exercise-Induced Muscle Damage and Anabolic/Catabolic Hormones in Elite Male Endurance Athletes

Biomolecules ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 140 ◽  
Author(s):  
Julen Fernández-Landa ◽  
Diego Fernández-Lázaro ◽  
Julio Calleja-González ◽  
Alberto Caballero-García ◽  
Alfredo Córdova ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Muscle Damage ◽  
Controlled Trial ◽  
Antagonistic Effect ◽  
Creatine Monohydrate ◽  
Double Blind ◽  
Long Term Effect ◽  
Combined Supplementation ◽  
Exercise Induced

Creatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB) are widely studied ergogenic aids. However, both supplements are usually studied in an isolated manner. The few studies that have investigated the effect of combining both supplements on exercise-induced muscle damage (EIMD) and hormone status have reported controversial results. Therefore, the main purpose of this study was to determine the effect and degree of potentiation of 10 weeks of CrM plus HMB supplementation on EIMD and anabolic/catabolic hormones. This study was a double-blind, placebo-controlled trial where participants (n = 28) were randomized into four different groups: placebo group (PLG; n = 7), CrM group (CrMG; 0.04 g/kg/day of CrM; n = 7), HMB group (HMBG; 3 g/day of HMB; n = 7), and CrM-HMB group (CrM-HMBG; 0.04 g/kg/day of CrM plus 3 g/day of HMB; n = 7). Before (baseline, T1) and after 10 weeks of supplementation (T2), blood samples were collected from all rowers. There were no significant differences in the EIMD markers (aspartate aminotransferase, lactate dehydrogenase, and creatine kinase) among groups. However, we observed significant differences in CrM-HMBG with respect to PLG, CrMG, and HMBG on testosterone (p = 0.006; η2p = 0.454) and the testosterone/cortisol ratio (T/C; p = 0.032; η2p = 0.349). Moreover, we found a synergistic effect of combined supplementation on testosterone (CrM-HMBG = −63.85% vs. CrMG + HMBG = −37.89%) and T/C (CrM-HMBG = 680% vs. CrMG + HMBG = 57.68%) and an antagonistic effect on cortisol (CrM-HMBG = 131.55% vs. CrMG + HMBG = 389.99%). In summary, the combination of CrM plus HMB showed an increase in testosterone and T/C compared with the other groups after 10 weeks of supplementation. Moreover, this combination presented a synergistic effect on testosterone and T/C and an antagonistic effect on cortisol compared with the sum of individual or isolated supplementation.

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