scholarly journals Can size alone explain some of the differences in toxicity between β-amyloid oligomers and fibrils?

2010 ◽  
pp. n/a-n/a
Author(s):  
Ben Keshet ◽  
In Hong Yang ◽  
Theresa A. Good
Keyword(s):  
Amyloid Oligomers ◽  
Β Amyloid

scholarly journals Cell stiffness and ROS level alterations in living neurons mediated by β-amyloid oligomers measured by scanning ion-conductance microscopy.

2021 ◽  
Vol 27 (S1) ◽  
pp. 500-502
Author(s):  
Oleg Suchalko ◽  
Roman Timoshenko ◽  
Alexander Vaneev ◽  
Vasilii Kolmogorov ◽  
Nikita Savin ◽  
...  
Keyword(s):  
Cell Stiffness ◽  
Ion Conductance ◽  
Scanning Ion Conductance Microscopy ◽  
Amyloid Oligomers ◽  
Β Amyloid ◽  
Living Neurons

scholarly journals Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis

2016 ◽  
Vol 36 (45) ◽  
pp. 11532-11543 ◽  
Author(s):  
Brooke L. Sinnen ◽  
Aaron B. Bowen ◽  
Emily S. Gibson ◽  
Matthew J. Kennedy
Keyword(s):  
Nmda Receptor ◽  
Receptor Function ◽  
Amyloid Oligomers ◽  
Quantal Analysis ◽  
Nmda Receptor Function ◽  
Β Amyloid

scholarly journals ROSETTA-informed design of structurally stabilized cyclic anti-amyloid peptides

2019 ◽  
Vol 32 (2) ◽  
pp. 47-57 ◽  
Author(s):  
Chandler B Est ◽  
Parth Mangrolia ◽  
Regina M Murphy
Keyword(s):  
Amyloid Fibril ◽  
Cyclic Peptide ◽  
Bond Formation ◽  
Amyloid Peptides ◽  
Linear Peptide ◽  
Toxic Species ◽  
Disulfide Linkages ◽  
Amyloid Oligomers ◽  
Β Amyloid ◽  
Β Sheet

Abstract β-amyloid oligomers are thought to be the most toxic species formed en route to fibril deposition in Alzheimer’s disease. Transthyretin is a natural sequestering agent of β-amyloid oligomers: the binding site to β-amyloid has been traced to strands G/H of the inner β-sheet of transthyretin. A linear peptide, with the same primary sequence as the β-amyloid binding domain on transthyretin, was moderately effective at inhibiting β-amyloid fibril growth. Insertion of a β-turn template and cyclization greatly increased stability against proteolysis and improved efficacy as an amyloid inhibitor. However, the cyclic peptide still contained a significant amount of disorder. Using the Simple Cyclic Peptide Application within ROSETTA as an in silico predictor of cyclic peptide conformation and stability, we investigated putative structural enhancements, including stabilization by disulfide linkages and insertion of a second β-turn template. Several candidates were synthesized and tested for secondary structure and ability to inhibit β-amyloid aggregation. The results demonstrate that cyclization, β-sheet structure and conformational homogeneity are all preferable design features, whereas disulfide bond formation across the two β-strands is not preferable.

scholarly journals A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic β-Amyloid Oligomers

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e39485 ◽  
Author(s):  
Lívia Fülöp ◽  
István M. Mándity ◽  
Gábor Juhász ◽  
Viktor Szegedi ◽  
Anasztázia Hetényi ◽  
...  
Keyword(s):  
Amyloid Oligomers ◽  
Β Amyloid

scholarly journals Size-dependent neurotoxicity of β-amyloid oligomers

2010 ◽  
Vol 496 (2) ◽  
pp. 84-92 ◽  
Author(s):  
Paulius Cizas ◽  
Rima Budvytyte ◽  
Ramune Morkuniene ◽  
Radu Moldovan ◽  
Matteo Broccio ◽  
...  
Keyword(s):  
Size Dependent ◽  
Amyloid Oligomers ◽  
Β Amyloid

S4-03-03: Direct neuron to neuron transmission of β-amyloid oligomers causes neurodegeneration

2011 ◽  
Vol 7 ◽  
pp. e2-e2
Author(s):  
Sangeeta Nath ◽  
Lotta Agholme ◽  
Firoz Roshan Kurudenkandy ◽  
Björn Granseth ◽  
Jan Marcusson ◽  
...  
Keyword(s):  
Amyloid Oligomers ◽  
Β Amyloid

Membrane‐bound β‐amyloid oligomers are recruited into lipid rafts by a fyn‐dependent mechanism

2007 ◽  
Vol 22 (5) ◽  
pp. 1552-1559 ◽  
Author(s):  
Ritchie Williamson ◽  
Alessia Usardi ◽  
Diane P. Hanger ◽  
Brian H. Anderton
Keyword(s):  
Lipid Rafts ◽  
Amyloid Oligomers ◽  
Membrane Bound ◽  
Β Amyloid ◽  
Dependent Mechanism

scholarly journals β-amyloid oligomers and prion protein

Prion ◽  
2011 ◽  
Vol 5 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Gianluigi Forloni ◽  
Claudia Balducci
Keyword(s):  
Prion Protein ◽  
Amyloid Oligomers ◽  
Β Amyloid
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