Optimization of fed-batch parameters and harvest time of CHO cell cultures for a glycosylated product with multiple mechanisms of inactivation

2007 ◽  
Vol 98 (2) ◽  
pp. 378-390 ◽  
Author(s):  
Ryan S. Senger ◽  
M. Nazmul Karim
Keyword(s):  
Cell Cultures ◽  
Harvest Time ◽  
Fed Batch ◽  
Cho Cell ◽  
Batch Parameters

Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures

2004 ◽  
Vol 89 (2) ◽  
pp. 164-177 ◽  
Author(s):  
Danny Chee Furng Wong ◽  
Kathy Tin Kam Wong ◽  
Lin Tang Goh ◽  
Chew Kiat Heng ◽  
Miranda Gek Sim Yap
Keyword(s):  
Cell Cultures ◽  
Fed Batch ◽  
Cho Cell

Transcriptomic responses to sodium chloride-induced osmotic stress: A study of industrial fed-batch CHO cell cultures

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Duan Shen ◽  
Thomas R. Kiehl ◽  
Sarwat F. Khattak ◽  
Zheng Jian Li ◽  
Aiqing He ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Osmotic Stress ◽  
Cell Cultures ◽  
Fed Batch ◽  
Cho Cell ◽  
Transcriptomic Responses

Transcriptional profiling of apoptotic pathways in batch and fed-batch CHO cell cultures

2006 ◽  
Vol 94 (2) ◽  
pp. 373-382 ◽  
Author(s):  
Danny Chee Furng Wong ◽  
Kathy Tin Kam Wong ◽  
Yih Yean Lee ◽  
Peter Nissom Morin ◽  
Chew Kiat Heng ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Transcriptional Profiling ◽  
Fed Batch ◽  
Cho Cell ◽  
Apoptotic Pathways

In silico model-based characterization of metabolic response to harsh sparging stress in fed-batch CHO cell cultures

2020 ◽  
Vol 308 ◽  
pp. 10-20 ◽  
Author(s):  
Jong Kwang Hong ◽  
Hock Chuan Yeo ◽  
Meiyappan Lakshmanan ◽  
Sung-hyuk Han ◽  
Hyun Myoung Cha ◽  
...  
Keyword(s):  
Cell Cultures ◽  
In Silico ◽  
Metabolic Response ◽  
Fed Batch ◽  
Cho Cell ◽  
Model Based ◽  
In Silico Model

Targeting early apoptotic genes in batch and fed-batch CHO cell cultures

2006 ◽  
Vol 95 (3) ◽  
pp. 350-361 ◽  
Author(s):  
Danny Chee Furng Wong ◽  
Kathy Tin Kam Wong ◽  
Peter Morin Nissom ◽  
Chew Kiat Heng ◽  
Miranda Gek Sim Yap
Keyword(s):  
Cell Cultures ◽  
Fed Batch ◽  
Cho Cell ◽  
Apoptotic Genes

The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion

2017 ◽  
Vol 12 (7) ◽  
pp. 1600633 ◽  
Author(s):  
Matthias Brunner ◽  
Philipp Braun ◽  
Philipp Doppler ◽  
Christoph Posch ◽  
Dirk Behrens ◽  
...  
Keyword(s):  
Intracellular Ph ◽  
Batch Process ◽  
Cell Physiology ◽  
Process Performance ◽  
Fed Batch ◽  
Cho Cell ◽  
Scale Down ◽  
The Impact

Monitoring CHO cell cultures: Cell stress and early apoptosis assessment by mass spectrometry

2013 ◽  
Vol 168 (4) ◽  
pp. 452-461 ◽  
Author(s):  
Sebastian Schwamb ◽  
Bogdan Munteanu ◽  
Björn Meyer ◽  
Carsten Hopf ◽  
Mathias Hafner ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cell Cultures ◽  
Cell Stress ◽  
Cho Cell ◽  
Early Apoptosis

A Comparative Transcriptomics Workflow for Analyzing Microarray Data From CHO Cell Cultures

2017 ◽  
Vol 13 (3) ◽  
pp. 1700228 ◽  
Author(s):  
Chun Chen ◽  
Huong Le ◽  
Brian Follstad ◽  
Chetan T. Goudar
Keyword(s):  
Cell Cultures ◽  
Microarray Data ◽  
Comparative Transcriptomics ◽  
Cho Cell
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