The use of UV-visible spectroscopy for the determination of hydrophobic interactions between neuropeptides and membrane model systems

Biopolymers ◽  
1992 ◽  
Vol 32 (8) ◽  
pp. 1061-1064 ◽  
Author(s):  
John K. Young ◽  
William H. Graham ◽  
Debbie J. Beard ◽  
Rickey P. Hicks
Keyword(s):  
Hydrophobic Interactions ◽  
Model Systems ◽  
Membrane Model ◽  
Visible Spectroscopy ◽  
Uv Visible

Determination of pKa of felodipine using UV–Visible spectroscopy

2013 ◽  
Vol 115 ◽  
pp. 887-890 ◽  
Author(s):  
M.M. Pandey ◽  
A. Jaipal ◽  
A. Kumar ◽  
R. Malik ◽  
S.Y. Charde
Keyword(s):  
Visible Spectroscopy ◽  
Uv Visible

Determination of Rate Constants in Second-Order Kinetics Using UV-Visible Spectroscopy

2001 ◽  
Vol 55 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Sabina Bijlsma ◽  
Hans F. M. Boelens ◽  
Age K. Smilde
Keyword(s):  
Rate Constants ◽  
Second Order ◽  
Visible Spectroscopy ◽  
Uv Visible

scholarly journals DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF GEMCITABINE HYDROCHLORIDE IN BULK AND POLYMERIC NANOPARTICLES

2017 ◽  
Vol 9 (5) ◽  
pp. 60 ◽  
Author(s):  
Taranjit Kaur ◽  
Sukhjinder Kaur ◽  
Parminderjit Kaur
Keyword(s):  
Polymeric Nanoparticles ◽  
Visible Spectroscopy ◽  
International Conference ◽  
Spectrophotometric Methods ◽  
Gemcitabine Hydrochloride ◽  
Double Beam ◽  
Uv Visible ◽  
Formulation Analysis ◽  
Development And Validation

Objective: The objective of the present work was to develop and validate a novel, specific, precise and reliable method for estimation of gemcitabine hydrochloride in bulk and polymeric nanoparticles using UV-visible spectroscopy method.Methods: The UV-Visible spectrophotometric determination was performed with double beam Systronics UV-visible spectrophotometer; model UV-2201 (India). The proposed methods were validated for various parameters like linearity, precision, accuracy, robustness, ruggedness, detection, quantification limits, and formulation analysis as per international conference on harmonization (ICH) guidelines.Results: The method was based on measurement of absorbance at wavelength maxima i.e. 267.2 nm, λmax of the drug in distilled water, phosphate buffer pH 6.8 and 7.4. The method obeyed Beer Lambert’s law in the concentration range of 5-30 µg/ml andR2-value was found to be 0.999. Moreover, the % drug recovered from polymeric nanoparticles was found to be 97.97%.Conclusion: According to results, the currently developed method shows compliance with acceptance criteria with Q2 (R1) and international conference on harmonization (2005) guidelines, because the % RSD was found to be less than 2%. The developed method was simple, accurate and précised.

Charge-Transfer Complexes Between Iodine and Substituted Thioureas: Determination of Thermodynamic and Spectroscopic Properties

1996 ◽  
Vol 51 (1-2) ◽  
pp. 116-122 ◽  
Author(s):  
Cornelia Fooken ◽  
Wolfram Baumann
Keyword(s):  
Equilibrium Constants ◽  
Spectroscopic Properties ◽  
Critical Discussion ◽  
Charge Transfer Complexes ◽  
Published Data ◽  
Visible Spectroscopy ◽  
Dichloromethane Solution ◽  
Uv Visible ◽  
Iodine Complexes

Abstract 15 iodine complexes with substituted thioureas were investigated in dichloromethane solution by UV-visible spectroscopy, and their equilibrium constants, reaction enthalpies and molar absorption coefficients were determined. The influence of the substituents on the properties of the charge-trans-fer complexes is examined. A critical discussion of previously published data is given, where comparable data are available.

scholarly journals Study of the β-Cyclodextrin Imipramine Hydrochloride Inclusion Complex and Determination of its Stability Constant (K) by UV-Visible Spectroscopy

2007 ◽  
Vol 4 (4) ◽  
pp. 550-558 ◽  
Author(s):  
Alamdar Ashnagar ◽  
Nahid Gharib Naseri ◽  
Bita Khanaki
Keyword(s):  
Stability Constant ◽  
Inclusion Complex ◽  
Visible Spectroscopy ◽  
Constant Amount ◽  
A Value ◽  
Visible Spectra ◽  
Imipramine Hydrochloride ◽  
Uv Visible ◽  
The Stability

In this research, the interactions of imipramine hydrochloride drug with β- cyclodextrin and the stability constant (K) of the inclusion complex formed between them were investigated by using UV-visible spectroscopy. Solutions consisting of a known and constant amount of imipramine hydrochloride and varying amounts of β- cyclodextrin were prepared in 0.1 M phosphate buffer (pH 7.4). The final solutions had cyclodextrin concentrations between 0.0011 and 0.0153 M. UV-visible spectra of each solution was taken at λmax= 250 nm. The absorbances at this wavelength were recorded and plotted against cyclodextrin concentrations. From the graph, the concentrations of free and bound imipramine hydrochloride and free β-cyclodextrin were calculated using the Beer-Lambert law. From these data, the stability constant was calculated and a value of K=52.26±11.41 mol-1L was obtained. The magnitude of the stability constant is discussed in terms of the relative sizes and the chemical natures of β-cyclodextrin and imipramine hydrochloride.

scholarly journals A first-in-class and a fished out anticancer platinum compound: cis-[PtCl2(NH3)2] and cis-[PtI2(NH3)2] compared for their reactivity towards DNA model systems

2016 ◽  
Vol 45 (20) ◽  
pp. 8587-8600 ◽  
Author(s):  
Domenica Musumeci ◽  
Chiara Platella ◽  
Claudia Riccardi ◽  
Antonello Merlino ◽  
Tiziano Marzo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Circular Dichroism ◽  
Electrospray Mass Spectrometry ◽  
Model Systems ◽  
Platinum Compound ◽  
Visible Spectroscopy ◽  
G Quadruplex ◽  
Uv Visible ◽  
Circular Dichroïsm

The reactivity of cis-PtI2(NH3)2 with selected DNA model systems, in single, double strand or G-quadruplex form, has been studied by circular dichroism, UV-visible spectroscopy and electrospray mass spectrometry using cisplatin as a control.

scholarly journals Determination of the Biodiesel Content in Petrodiesel/Biodiesel Blends: A Method Based on Uv-Visible Spectroscopy and Chemometrics Tools

2013 ◽  
Vol 04 (06) ◽  
pp. 273-276
Author(s):  
Armando Guerrero ◽  
Francisco Anguebes ◽  
Mepivoseth Castelán ◽  
Victorino Morales ◽  
Ismael León ◽  
...  
Keyword(s):  
Visible Spectroscopy ◽  
Biodiesel Blends ◽  
Uv Visible

Determination of the content and identity of lidocaine solutions with UV–visible spectroscopy and multivariate calibration

The Analyst ◽  
2001 ◽  
Vol 126 (7) ◽  
pp. 1142-1148 ◽  
Author(s):  
Kent Wiberg ◽  
Anders Hagman ◽  
Sven P. Jacobsson ◽  
Peter Burén
Keyword(s):  
Multivariate Calibration ◽  
Visible Spectroscopy ◽  
Uv Visible
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